Term
|
Definition
| released by macrophages and lymphocytes to activate IL-12 production by macrophages; activates NK cells; induces apoptosis, inflammation; inhibits viral replication; causes selectin expression on endothelial cells; promotes collage synthesis in wound healing |
|
|
Term
|
Definition
| released by NK and T cells to activate macrophages to digest microbes; also stimulates class switching to IgG3 |
|
|
Term
|
Definition
| hematopoietic growth factor; stimulates differentiation of pluripotent stem cells into myeloid progenitor cells and then stimulates proliferation of all cells in myeloid lineage |
|
|
Term
|
Definition
| marker on B cell; binds to CD40L found on helper T cells to activate B cells; also found on other APC's |
|
|
Term
|
Definition
| marker on helper T cells; binds to MHC II |
|
|
Term
|
Definition
| marker on killer T cells; binds to MHC I |
|
|
Term
|
Definition
| marker on all T cells that protrudes inward to work with TCR to send activation signal |
|
|
Term
| Ig-alpha & Ig-beta (CD79) |
|
Definition
| markers that protrude inwards on B cell and work with BCR to send activation signal to nucleus |
|
|
Term
|
Definition
| marker on APCs; binds to CD28 on T cells to activate them; co-stimulatory signal |
|
|
Term
|
Definition
| on T cells; binds with B7 to send activation signal to T cell |
|
|
Term
|
Definition
| nonclassical MHC molecule bound to B2 microglobulin; binds lipids; presented by dendritic cells to natural killer T cells and γ/δ T cells (may play role in TB) |
|
|
Term
|
Definition
| growth factor for B cells and TH2 cells; stimulates IgE class switching (good for parasitic infections) |
|
|
Term
|
Definition
| stimulates IgA production (good for mucosal infections) |
|
|
Term
|
Definition
| produced by regulatory T cells; inhibits TH1 cells |
|
|
Term
|
Definition
| marker on T cell whose expression is induced after prolonged stimulation to inhibit T cells; B7 binds to CTLA-4, which competes with CD28 |
|
|
Term
|
Definition
| produced by regulatory T cells to inhibit T cells; inhibits breakdown of collagen to promote scar tissue; inhibits cell cycle |
|
|
Term
|
Definition
| cellular protein that protects against apoptosis |
|
|
Term
|
Definition
| associated with activation of induced cell death of lymphocytes that are restimulated continually |
|
|
Term
|
Definition
| chemokine; receptors for CCR7 are on T cells and dendritic cells and causes them to go to the paracortex region of lymph nodes |
|
|
Term
|
Definition
| chemokine; receptors for CXCR5 on B cells; produced only in follicles and attracts B cells here |
|
|
Term
|
Definition
| acts as B-cell co-receptor (activates B cell) with CD21 and CD81 to bind complement; also found on FDCs |
|
|
Term
|
Definition
|
|
Term
|
Definition
| marker on T cells and a subset of B cells (produce IgM, don't undergo somatic hypermutation and don't require T cell help) |
|
|
Term
|
Definition
| alarm cytokine; released by macrophages and dendritic cells once activated; induces selectin expression on endothelial cells; promotes collagen synthesis in wound healing |
|
|
Term
|
Definition
| marker on helper T cells that binds to CD40 on APCs to activate them |
|
|
Term
|
Definition
| Fc receptor for IgG found on NKs (ADCC); also found on neutrophils and macrophages (opsonization) |
|
|
Term
|
Definition
| produced by lymphocytes, macrophages, dendritic cells, fibroblasts, endothelial cells; activates macrophages and NK cells to increase anti-viral and anti-tumor activity |
|
|
Term
|
Definition
| produced by macrophages and other APCs; activates NKs and T cells & causes release of IFN-gamma release |
|
|
Term
|
Definition
| stimulates neutrophil, C Reactive Protein and fibrinogen formation; causes liver to produce acute phase proteins; primes cells for entry into cell cycle |
|
|
Term
|
Definition
| growth factor for T cells and NK cells; works by inducing signal cascade that will turn on gene transcription |
|
|
Term
|
Definition
| inhibits addition of C9 to cell membrane and so MAC cannot be formed |
|
|
Term
|
Definition
| CR1; found on macrophages, neutrophils, B cells, RBCs and T cells; causes phagocytosis, immune complex clearing; co-factor for C3b and C4b degredation to inhibit C3 & C5 convertases |
|
|
Term
|
Definition
| CR2; found on B cells and FDCs; co-receptor for B cell activation and traps antigen in germinal centers; receptor for EBV |
|
|
Term
|
Definition
| CR3 & CR4; found on NK cells, macrophages and neutrophils; phagocytosis and leukocytic adhesion |
|
|
Term
|
Definition
| hematopoietic growth factor; stimulates differentiation of pluripotent stem cells into lymphoid progenitor cells and then stimulates proliferation of all cells in lymphoid lineage |
|
|
Term
|
Definition
| stimulates cell proliferation and inhibits apoptosis |
|
|
Term
|
Definition
| important in maintaining memory cells; induces activation & proliferation of T cells and NKs |
|
|
Term
|
Definition
| cell adhesion and co-stimulatory molecule found on T cells and NKs; binds to LFA-3 on target cell |
|
|
Term
|
Definition
| signaling molecule in the protein kinase phosphatase class in B and T cells |
|
|
Term
|
Definition
|
|
Term
|
Definition
| FcγR11 Fc receptor; involved in negative feedback control |
|
|
