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CYP Enzymes and Drugs
A list of common CYP Enzymes and the drugs they metabolize, that are inhibited by, and are induced by
22
Pharmacology
Professional
02/03/2011

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Cards

Term
Most common inducers
Definition
Carbamazepine (autoinducer), Rifampin, Phenytoin, Phenobarbita,l St. Johns Wort
Term
Major inhibitors of 3A4
Definition
Amiodarone Cimetidine Clarithromycin Erythromycin Grapefruit Juice Itraconazole Ketoconazole
Term
Major inducers of 3A4
Definition
Carbamazepine Glucocorticoids Phenytoin Rifampin Ritonavir
Term
Major Inhibitors of 1A2
Definition
Cimetidine Ciprofloxacin Clarithromycin Enoxacin Erythromycin Fluvoxamine Ofloxacine Ticlopidine
Term
Major inducers of 1A2
Definition
Hydrocarbons (cigarette smoke)
Term
Major substrates of 1A2
Definition
Clozapine Cyclobenzaprine Fluvoxamine Imipramine Mexiletine Propranolol Theophylline
Term
Most important substrate of 1A2
Definition
Theophylline
Term
1A2 mostly metabolizes what medication types?
Definition
Head meds
Term
Major substrates of 2C9
Definition
Diclofenac Ibuprofen Losartan Naproxen Phenytoin Piroxicam Sulfamethoxazole Warfarin
Term
2C9 metaboles what meds?
Definition
Warfarin and NSAIDs
Term
Major Inhibitors of 2C9
Definition
Amiodarone Fluconazole Fluoxetine(SSRI) Isoniazid (TB) Paroxetine (SSRI) Ticlopidine (SSRI) Zafirlukast
Term
Two most important inhibitors of 2C9
Definition
Amiodarone and flucanazole
Term
Major inducers of 2C9
Definition
Phenobarbital Rifampin
Term
Major substrates of 2C19
Definition
Amitriptyline Clomipramine Ciclophosphamide Diazepam Imiprimine Lansoprazole Omeprazole Phenytoin Clopidogrel
Term
Most important substrate of 2C19
Definition
Clopedigrel
Term
Major inducers of 2C19
Definition
Carbamazepine Norethindrone
Term
Major inhibitors of 2C19
Definition
Cimetidine Fluoxetine Fluvoxamine Ketoconazole Lansoprazole Omeprazole Paroxetine Ticlopidine
Term
2C19 is inhibited by what classes?
Definition
SSRIs (paraxetine) and PPIs
Term
Major Substrates of 2E1
Definition
APAP Chlorzoxazone Ethanol Enflurane Halothane Isolurane
Term
Major Inducers of 2E1
Definition
Isonizid and Chronic Ethanol
Term
Major Inhibitors of 2D6
Definition
Amiodarone Fluoxetine Haloperidol Indinavir Paroxetine Quinidine Ritonavir Sertraline
Term
Major inducer of 2D6
Definition
Rifampin
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