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CV drugs-diuretics
diuretics
12
Pharmacology
Professional
11/27/2011

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Cards

Term
mannitol
Definition
osmotic
MOA: hydrophilic chemical that filters through glomerulus
I: increased intracranial pressure, acute renal failure, drug toxicity, or trauma
SE: hypo/hypernatremia, dehydration
Term
acetazolamide
Definition
carbonic anhydrase inhibitor at the proximal tubule
MOA: H+ stays in the lumen and then Na+ doesn't get reabsorbed
SE: metabolic acidosis, aplastic anemia
CI: sulfa allergy
Term
hydrochlorothiazide
Definition
thiazide
I: HTN, CHF, hypercalciruria
MOA: inhibits Na/Cl cotransporter of distal convoluted tubule so decreased Na+ reabsorption
SE: hypokalemia
sulfa allergy
Term
Loop Diuretics
Definition
MOA: inhibits cotransport of Na/K/2Cl in ascending loop of Henle
I: edema, CHF, hypercalcemia, hyperkalemia esp in renal insufficient pts
SEL ototoxic, hyperuricemia, hypokalemia, hypomagnesemia, hypocalcemia
Term
ethacrynic acid
Definition
loop diuretic
MORE ototoxic
Term
torsemide
Definition
loop diuretic
Term
triamterine
Definition
k+ sparing
MOA: block Na/K antiport in collecting tubule
SE: hyperkalemia, leg cramps, hyperuricemia
Term
spironolactone
Definition
K+ sparing
MOA: steroid that antagnoizes aldosterone receptor
I: secondary hyperaldosteronism, diuretic, CHF
SE: gynecomastia, menstural irregularities
Term
amiloride
Definition
K+ sparing
Term
Sulfa allergy drugs
Definition
acetazolamide
furosemide
torasemide
hydrochlorothiazide
NOT ethacrynic acid and K+ sparing
Term
furosemide
Definition
loop diuretic
Term
[image]
Definition
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