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SYSTEMATIC REVIEW: Found low level of evidence relating VZV to apical periodontitis and root resorption. However, a potential role of VZV in the etiology of periapical pathosis and root resorption cannot be ruled out.
**Review pathogenesis of VZV** |
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Biomechanical instrumentation reduces microorganisms and endotoxins, but not completely.
Presence of previous pain was related to P. nigrescens
Tenderness to percussion was related to P. gingivalis, V. parvula, C. sputigena, P. nigrescens, and E. saburreum
Sinus tract was related to gram positive bacteria and facultative anaerobes: E. corrodens, P. micra, C. showae, E. saburreum |
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The risk of developing AP in endodontically treated teeth is 5.19 times higher for patients with periodontal disease undergoing perio treatment compared with patients without periodontal disease.
*Sc/RP--> loss of cementum--> open dentinal tubules--> bacteria into RCT system |
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BEAGLE STUDY: The addition of chitosan scaffolds did not improve the formation of mineralized tissues along root canal walls and histologic evidence of regeneration.
Apical papilla survive and continue to differentiate after infection. |
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G-CSF and FGF-2 were most effective in recruiting SCAPs, but G-CSF in combination with TGF B1 promoted greater differentiation into a mineralizing phenotype than FGF-2.
G-CSF appears to be a particularly suitable chemotactic factor in RegEndo because it induces robust migration and differentiation of SCAPs and its effects are augmented by TGF-B1. |
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MICRO-CT STUDY: 77.41% mid-mesial canals can be accessed without troughing (orifice found at the level of the CEJ)
• 5.38% would need to be troughed 1 mm deep
• 9.69% would need to be troughed 2mm deep
• 7.52% were deeper than 2mm and could not be accessed by troughing.
• Found no significant relationship between orifice depth and configuration |
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| Preparing a cavity in the coronal core followed by ultrasonic vibration reduces the traction force required for removal. The removal protocol is effective for removing posts in multirooted teeth cemented with zinc phosphate. |
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| CASE STUDIES: Endodontic therapy with Platelet-rich Plasma (PRP) of necrotic teeth with open apices and apical periodontitis and with nonsurgical endodontic retreatment appears to be predictable and a good option in ADULTS, obtaining periapical tissue repair according to clinical and radiographic criteria. It is difficult to tell whether repair or regeneration was obtained because it was not possible to obtain a histologic evaluation. |
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| Treatment of nonvital, immature permanent incisors with MTA apical plug and an adhesive restoration led to long term tooth survival. |
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