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CSU BMS 300 Walrond
Human Physiology Unit 1: Cells
74
Physiology
Undergraduate 1
02/01/2013

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Term
Why is water polar?
Definition
The electrons in the molecule spend more time near the oxygen atom than near the proton in each of the two hydrogen atoms.
Term
Which end of the water molecule has a negative charge?
Definition
Oxygen.
Term
What type of ions are readily soluble in water?
Definition
Charged ions.
Term
Why aren't molecules such as lipids readily soluble in water?
Definition
They are non-polar or uncharged.
Term
What is diffusion?
Definition
When molecules or ions in solution go from regions of higher to regions of lower ion concentration until the molecules are evenly distributed and equilibrium is reached.
Term
In biological systems, what are the channels that permit the movement of ions from a region of higher to lower concentration, i.e., down a concentration gradient?
Definition
Transmembrane proteins.
Term
What permit the diffusion of positively charged ions?
Definition
Cation channels.
Term
What permit the diffusion of negatively charged ions?
Definition
Anion channels.
Term
What is another name for water diffusion through channels?
Definition
Osmosis.
Term
In biological systems, what are the transmembrane proteins that permit the diffusion of water molecules down a concentration gradient called?
Definition
Aquaporins.
Term
What is referred to as the "elixir of life?"
Definition
Water
Term
What does amphipathic refer to?
Definition
Molecules that have both hydrophilic and hydrophobic characteristics.
Term
What is an example of an amphipathic molecule?
Definition
Phospholipids.
Term
What provides the boundary between the inside and outside of the cell and allows for the separation of ions?
Definition
Cell membrane.
Term
What is the cell membrane?
Definition
Essentially a lipid bilayer punctuated by membrane proteins.
Term
What are proteins constructed of?
Definition
Long chains of amino acids.
Term
How many common amino acids are there?
Definition
20.
Term
What do amino acids contain?
Definition
Carboxyl group and an amino group linked by a carbon + an R group attached to this carbon.
Term
What is characteristic for each of the 20 amino acids?
Definition
R group.
Term
What is NH2?
Definition
Amine group.
Term
What is COOH?
Definition
A carboxylic acid group.
Term
What is OH?
Definition
A hydroxyl group.
Term
What determines an amino acid's identity?
Definition
The R group.
Term
What is the peptide bond?
Definition
The site where amino acids are linked one to another in the chain.
Term
What controls peptide bond formation?
Definition
The ribosome where mRNA, rRNA, and tRNA come together in the act of protein translation.
Term
What is the secondary structure of proteins?
Definition
Alpha helicial.
Term
What determines the function of a protein?
Definition
Three-dimensional shape.
Term
What determines the protein's three-dimensional shape?
Definition
The interaction of the R groups.
Term
What are phospholipids constructed from?
Definition
Glycerol.
Term
What is glycerol constructed from?
Definition
A three carbon chain with one hydroxyl (OH) group attached to each carbon.
Term
What are fatty acids constructed from?
Definition
Long chains of carbon with a carboxylic acid group at one end.
Term
What forms the backbone of a lipid molecule?
Definition
Glycerol.
Term
What is C-O-C?
Definition
An ester bond.
Term
What does esterfication yield?
Definition
Water.
Term
What links amino acids one to another?
Definition
Peptide bonds.
Term
What is a peptide bond?
Definition
When the carbon on the carboxyl group forms a covalent bond with the nitrogen in the amine group in the adjacent amino acid.
Term
For phospholipids, what is the third carbon on the glycerol linked to?
Definition
A phosphate (PO3) by an ester linkage which is in turn linked to another molecule such as choline, serine, or ethanolamine through an ester bond.
Term
In all cells, what is the interface between the environment inside the cell and the outside world?
Definition
Cell membrane.
Term
In what model does the cell membrane consist of a bilayer of phospholipids punctuated by proteins that span the bilayer?
Definition
Lipid mosaic model.
Term
What is another name for substrate?
Definition
Ligand.
Term
What do proteins in the membrane provide?
Definition
Access in and out of the cell for charged ions. (Hydrophilic pathways.)
Term
What are organelles?
Definition
Membrane bound compartments.
Term
Microtubules are made of what?
Definition
Tubulin.
Term
Intermediate filaments are made of what?
Definition
Keratin.
Term
Microfilaments are made of what?
Definition
G-actin and f-actin.
Term
A cell with a single, circular stand of DNA, free ribosomes and proteins dispersed through out is most likely what?
Definition
A prokaryote.
Term
Where does a protein in the membrane of a eukaryotic cell most likely originate from?
Definition
Rough ER.
Term
What is a lysosome made up of?
Definition
A plasma membrane and specialized hydrolytic enzymes.
Term
Kinesin is an enzyme that steps along microtubles, 8nm at a time. To do this, it must cleave ____ into ____. This makes it a ____.
Definition
ATP, ADP+Pi, ATPase.
Term
What is the function of helicase?
Definition
To break hydrogen bonds in double stranded DNA.
Term
T or F: The base pairs in DNA are bound to each other via covalent bonding.
Definition
False. Bound together with hydrogen bonds.
Term
Why doesn't the process of transcription require helicase?
Definition
Because RNA polymerase has properties that allow it to break the hydrogen bonds between bases.
Term
when is mRNA ready to be translated as is?
Definition
When it leaves the nucleus.
Term
When a mRNA strand has codons that encode a single peptide, the protein will be processed through the rough endoplasmic reticulum. Ultimately, where will this protein end up?
Definition
Transmembrane proteins, released from the cell via exocytosis, or to enter the lysosomes.
Term
What determines the function of a protein?
Definition
The three-dimensional shape it is folded into.
Term
What determines a protein's three-dimensional shape?
Definition
Interaction of the R groups.
Term
What are the three general types of ribonucleic acid in cells?
Definition
mRNA, rRNA, and tRNA.
Term
What occurs in the Golgi apparatus?
Definition
Protein processing.
Term
What are large vesicles called?
Definition
Vacuoles.
Term
What are the primary sites of energy production in cells?
Definition
Mitochondria.
Term
What imposes some structure and organization to cells?
Definition
Cytoskeleton.
Term
What are chromosomes primarily composed of?
Definition
DNA.
Term
What are DNA binding proteins that are located in the cell nucleus?
Definition
Histones.
Term
What is a nucleosome constructed of?
Definition
Eight histone molecules (octomer).
Term
What term refers to DNA that is visible in the light microscope?
Definition
Chromatin.
Term
What are DNA binding proteins located in the cell nucleus?
Definition
Histones.
Term
What is a single, long thread of DNA that must be packaged into the cell nucleus?
Definition
Chromosome.
Term
What is a nucleosome constructed from? What is another name for this?
Definition
Eight histone molecules. Octamer.
Term
What links one deoxyribose to the next along a strand of DNA?
Definition
Phosphate linkages.
Term
What type of bonds hold together the two strands of DNA?
Definition
Hydrogen.
Term
What does adenine always pair with?
Definition
Thymine. Uracil in RNA.
Term
What does cytosine always pair with?
Definition
Guanine.
Term
What causes the double helix's characteristic pitch?
Definition
The base pairing.
Term
From DNA to Protein. Replication of the DNA Molecule.
Definition
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