Term
HEADACHE Key History Onset (acute vs. chronic), location (unilateral vs. bilateral), quality (dull vs. stabbing), intensity (is it the “worst headache of their life”?), duration, timing (does it disturb sleep?), presence of associated neurologic symptoms (paresthesias, visual stigmata, weakness, numbness, ataxia, photophobia, dizziness, auras, neck stiffness); nausea/vomiting, jaw claudication, recent trauma, dental surgery, sinusitis symptoms; exacerbating factors (stress, fatigue, menses, exercise, certain foods) and alleviating factors (rest, medications); patient and family history of headache; history of trauma. |
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Definition
Key Physical Exam Vital signs; inspection and palpation of entire head; ENT inspection; complete neurologic exam, including funduscopic exam. |
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Term
21 yo F presents with several episodes of throbbing left temporal pain that last for 2–3 hours. Before onset, she sees flashes of light in her right visual field and feels weakness and numbness on the right side of her body for a few minutes. Her headaches are often associated with nausea and vomiting. She has a family history of migraine. |
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Definition
Migraine (complicated) Tension headache Cluster headache Pseudotumor cerebri CNS vasculitis Partial seizure Intracranial neoplasm * CBC ESR CT—head MRI—brain LP—CSF analysis |
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Term
26 yo M presents with severe right temporal headaches associated with ipsilateral rhinorrhea, eye tearing, and redness. Episodes have occurred at the same time every night for the past week and last for 45 minutes. |
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Definition
Cluster headache Migraine Tension headache Intracranial neoplasm Pseudotumor cerebri * CBC CT—head MRI—brain LP—CSF analysis ESR |
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Term
65 yo F presents with severe, intermittent right temporal headache, fever, blurred vision in her right eye, and pain in her jaw when chewing. |
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Definition
Temporal arteritis (giant cell arteritis) Migraine Cluster headache Tension headache Meningitis Carotid artery dissection Pseudotumor cerebri Trigeminal neuralgia Intracranial neoplasm Temporomandibular joint (TMJ) disorder * ESR CBC CRP Temporal artery biopsy Doppler U/S—carotid MRI—brain LP—CSF analysis |
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Term
30 yo F presents with frontal headache, fever, and nasal discharge. There is pain on palpation of the frontal and maxillary sinuses. She has a history of allergies. |
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Definition
Sinusitis Migraine Tension headache Meningitis Intracranial neoplasm * CBC XR—sinus CT—sinus LP—CSF analysis |
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Term
50 yo F presents with recurrent episodes of bilateral squeezing headaches that occur 3–4 times a week, typically toward the end of her work day. She is experiencing significant stress in her life and recently decreased her intake of caffeine. |
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Definition
Tension headache Migraine Depression Caffeine or analgesic withdrawal Hypertension Cluster headache Pseudotumor cerebri Intracranial neoplasm * CBC Electrolytes ESR CT—head LP—CSF analysis |
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Term
35 yo M presents with sudden severe headache, vomiting, confusion, left hemiplegia, and nuchal rigidity. |
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Definition
Subarachnoid hemorrhage Migraine Meningitis/encephalitis Intracranial hemorrhage Vertebral artery dissection Intracranial venous thrombosis Acute hypertension Intracranial neoplasm * Noncontrast CT—head LP—CSF analysis CBC PT/PTT/INR Urine toxicology |
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Term
25 yo M presents with high fever, severe headache, confusion, photophobia, and nuchal rigidity. |
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Definition
Meningitis Migraine Subarachnoid hemorrhage Sinusitis/encephalitis Intracranial or epidural abscess * CBC CT—head MRI—brain LP—CSF analysis (cell count, protein, glucose, Gram stain, PCR for specific pathogens, culture) |
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Term
18 yo obese F presents with a pulsatile headache, vomiting, and blurred vision for the past 2–3 weeks. She is taking OCPs. |
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Definition
Pseudotumor cerebri Tension headache Migraine Cluster headache Meningitis Intracranial venous thrombosis Intracranial neoplasm * Urine hCG CBC CT—head LP—opening pressure and CSF analysis |
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Term
57 yo M c/o daily pain in the right cheek for the past month. The pain is electric and stabbing in character and occurs while he is shaving. Each episode lasts 2–4 minutes. |
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Definition
Trigeminal neuralgia Tension headache Migraine Cluster headache TMJ disorder Intracranial neoplasm * CBC ESR MRI—brain |
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Term
CONFUSION/MEMORY LOSS Key History Must include history from family members/caregivers when available. Detailed time course of cognitive deficits (acute vs. chronic/gradual onset); associated symptoms (constitutional, incontinence, ataxia, hypothyroid symptoms, depression); screen for delirium (waxing/waning level of alertness); falls, medications (and recent medication changes); history of stroke or other atherosclerotic vascular disease, syphilis, HIV risk factors, alcohol use, or vitamin B12 deficiency; family history of Alzheimer’s disease or other neurologic disorders. |
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Definition
Key Physical Exam Vital signs; complete neurologic exam, including mini-mental status exam and gait; general physical exam, including ENT, heart, lungs, abdomen, and extremities. |
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Term
81 yo M presents with progressive confusion for the past several years accompanied by forgetfulness and clumsiness. He has a history of hypertension, diabetes mellitus, and 2 strokes with residual left hemiparesis. His mental status has worsened after each stroke (stepwise decline in cognitive function). |
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Definition
Vascular (“multiinfarct”) dementia Alzheimer’s disease Normal pressure hydrocephalus Chronic subdural hematoma Intracranial neoplasm Depression B12 deficiency Neurosyphilis Hypothyroidism * CBC VDRL/RPR Serum B12 TSH MRI—brain CT—head LP—CSF analysis |
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Term
84 yo F brought by her son c/o forgetfulness (eg, forgets phone numbers, loses her way back home) and difficulty performing some of her daily activities (eg, bathing, dressing, managing money, using the phone). The problem has progressed gradually over the past few years. |
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Definition
Alzheimer’s disease Vascular dementia Depression Hypothyroidism Chronic subdural hematoma Normal pressure hydrocephalus Intracranial neoplasm B12 deficiency Neurosyphilis * CBC VDRL/RPR Serum B12 TSH MRI—brain (preferred) CT—head LP—CSF analysis |
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Term
72 yo M presents with memory loss, gait disturbance, and urinary incontinence for the past 6 months. |
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Definition
Normal pressure hydrocephalus Alzheimer’s disease Vascular dementia Chronic subdural hematoma Intracranial neoplasm Depression B12 deficiency Neurosyphilis Hypothyroidism * CT—head MRI—brain LP—opening pressure and CSF analysis Serum B12 VDRL/RPR TSH |
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Term
55 yo M presents with a rapidly progressive change in mental status, inability to concentrate, and memory impairment for the past 2 months. His symptoms are associated with myoclonus, ataxia, and a startle response. |
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Definition
Creutzfeldt-Jakob disease Vascular dementia Lewy body dementia Wernicke’s encephalopathy Normal pressure hydrocephalus Chronic subdural hematoma Intracranial neoplasm Depression Delirium B12 deficiency Neurosyphilis * CBC Electrolytes, calcium Serum B12 VDRL/RPR MRI—brain (preferred) CT—head EEG LP—CSF analysis Brain biopsy |
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Term
70 yo insulin-dependent diabetic M presents with episodes of confusion, dizziness, palpitations, diaphoresis, and weakness. |
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Definition
Hypoglycemia Transient ischemic attack Arrhythmia Delirium Angina * Glucose CBC Electrolytes CPK-MB, troponin Echocardiography ECG MRI—brain Doppler U/S—carotid |
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Term
55 yo F presents with gradual altered mental status and headache. Two weeks ago she slipped, hit her head on the ground, and lost consciousness for 2 minutes. |
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Definition
Subdural hematoma SIADH (causing hyponatremia) Creutzfeldt-Jakob disease Intracranial neoplasm * CT—head CBC Electrolytes MRI—brain LP—CSF analysis |
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Term
LOSS OF VISION Key History Acute vs. chronic, progression, ability to see light; associated symptoms (eye pain, discharge, itching, tearing, photophobia, redness, headache, weakness, numbness, floaters, sparks); history of cardiac, rheumatic, thrombotic, autoimmune, or neurologic disorders; jaw claudication, medications, trauma. |
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Definition
Key Physical Exam Vital signs; cardiovascular, HEENT, funduscopic, and neurologic exams. |
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Term
73 yo M presents with acute loss of vision in his left eye, palpitations, and shortness of breath. He has a history of atrial fibrillation and cataracts in his right eye. He has no eye pain, discharge, redness, or photophobia. He has not experienced headache, weakness, or numbness. |
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Definition
Retinal artery occlusion Retinal vein occlusion Acute angle-closure glaucoma Retinal detachment Temporal arteritis (giant cell arteritis) * Fluorescein angiogram Echocardiography Doppler U/S—carotid Intraocular tonometry ESR Temporal artery biopsy CBC |
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Term
DEPRESSED MOOD Key History Onset, duration; sleep patterns; appetite and weight change; drug and alcohol use; life stresses, excessive guilt, suicidality, social function, decreased interest (anhedonia), decreased energy, decreased concentration, psychomotor agitation or retardation; family history of mood disorders; prior episodes; medications. |
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Definition
Key Physical Exam Vital signs; head and neck exam; neurologic exam; mental status exam, including documentation of appearance, behavior, speech, mood, affect, thought process, thought content, cognition (measured by the 30-point mini-mental status exam), insight, and judgment. |
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Term
68 yo M presents with a 2-month history of crying spells, excessive sleep, poor hygiene, and a 15-lb (6.8-kg) weight loss, all following his wife’s death. He cannot enjoy time with his grandchildren and admits to thinking he has seen his dead wife in line at the supermarket or standing in the kitchen making dinner. |
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Definition
Normal bereavement Adjustment disorder with depressed mood Major depressive disorder with psychotic features Schizoaffective disorder Depressive disorder not otherwise specified * Physical exam TSH CBC Urine toxicology Beck Depression Inventory |
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Term
42 yo F presents with a 4-week history of excessive fatigue, insomnia, and anhedonia. She states that she thinks constantly about death. She has suffered 5 similar episodes in the past, the first in her 20s, and has made 2 previous suicide attempts. She further admits to increased alcohol use in the past month. |
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Definition
Major depressive disorder Substance-induced mood disorder Dysthymic disorder * Physical exam Mental status exam Beck Depression Inventory Blood alcohol level TSH CBC Urine toxicology |
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Term
26 yo F presents with a 6.5-lb (2.9-kg) weight loss in the past 2 months, accompanied by early-morning awakening, excessive guilt, and psychomotor retardation. She does not identify a trigger for the depressive episode but reports several weeks of increased energy, sexual promiscuity, irresponsible spending, and racing thoughts approximately 6 months before her presentation. |
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Definition
Bipolar I disorder Bipolar II disorder Cyclothymic disorder Major depressive disorder Schizoaffective disorder * Physical exam Mental status exam Urine toxicology |
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Term
PSYCHOSIS Key History Positive symptoms (delusions, hallucinations, disorganized thoughts, disorganized or catatonic behavior), negative symptoms (blunted affect, social withdrawal, decreased motivation, decreased speech/thought), cognitive symptoms (disorganized speech or thought patterns, paranoia); age at first symptoms and/or hospitalization; previous psychiatric medications; alcohol and substance use. |
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Definition
Key Physical Exam Vital signs; mental status exam; during physical exam, pay particular attention to general appearance (eg, poor grooming, odd or poorly fitting clothing). |
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Term
19 yo M c/o receiving messages from his television set. He reports that he did not have many friends in high school. In college, he started to suspect his roommate of bugging the phone. He stopped going to classes because he felt that his professors were saying horrible things about him that no one else noticed. He rarely showered or left his room and has recently been hearing a voice from his television set telling him to “guard against the evil empire.” |
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Definition
Schizophrenia Schizoid or schizotypal personality disorder Schizophreniform disorder Psychotic disorder due to a general medical condition Substance-induced psychosis Depression with psychotic features * Mental status exam Urine toxicology TSH CBC Electrolytes |
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Term
28 yo F c/o seeing bugs crawling on her bed for the past 2 days and hearing loud voices when she is alone in her room. She has never experienced anything similar in the past. She recently ingested an unknown substance. |
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Definition
Substance-induced psychosis Brief psychotic disorder Schizophreniform disorder Schizophrenia Psychotic disorder due to a general medical condition * Urine toxicology Mental status exam TSH CBC Electrolytes, BUN/Cr AST/ALT |
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Term
48 yo F presents with a 1-week history of auditory hallucinations that state, “I am worthless” and “I should kill myself.” She also reports a 2-week history of weight loss, early-morning awakening, decreased motivation, and overwhelming feelings of guilt. |
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Definition
Schizoaffective disorder Mood disorder with psychotic features Schizophrenia Schizophreniform disorder Psychotic disorder due to a general medical condition * Mental status exam Beck Depression Inventory TSH CBC Electrolytes |
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Term
DIZZINESS Key History Lightheadedness vs. vertigo, ± auditory symptoms (hearing loss, tinnitus), duration of episodes, context (occurs with positioning, following head trauma); other associated symptoms (visual disturbance, URI, nausea); neck pain or injury; medications; history of atherosclerotic vascular disease. |
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Definition
Key Physical Exam Vital signs; complete neurologic exam, including Romberg test, nystagmus, tilt test (eg, Dix-Hallpike maneuver), gait, hearing, and Weber and Rinne tests; ENT exam; cardiovascular exam. |
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Term
35 yo F presents with intermittent episodes of vertigo, tinnitus, nausea, and hearing loss within the past week. |
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Definition
Ménière’s disease Vestibular neuronitis Labyrinthitis Benign positional vertigo Acoustic neuroma * CBC VDRL/RPR (syphilis is a cause of Ménière’s disease) MRI—brain Dix-Hallpike maneuver |
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Term
55 yo F c/o dizziness for the past day. She feels faint and has severe diarrhea that started 2 days ago. She takes furosemide for hypertension. |
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Definition
Orthostatic hypotension due to dehydration (diarrhea, diuretic use) Vestibular neuronitis Labyrinthitis Benign positional vertigo Vertebrobasilar insufficiency * Orthostatic vital signs CBC Electrolytes Rectal exam, stool for occult blood Stool leukocytes |
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Term
65 yo M presents with postural dizziness and unsteadiness. He has hypertension and was started on hydrochlorothiazide 2 days ago. |
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Definition
Drug-induced orthostatic hypotension Vestibular neuronitis Labyrinthitis Benign positional vertigo Brain stem or cerebellar tumor Acute renal failure * Orthostatic vital signs CBC Electrolytes Echocardiography MRI—brain |
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Term
44 yo F c/o dizziness on moving her head to the left. She feels that the room is spinning around her head. A tilt test results in nystagmus and nausea. |
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Definition
Benign positional vertigo Vestibular neuronitis Labyrinthitis Ménière’s disease * Dix-Hallpike maneuver MRI—brain Audiogram |
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Term
55 yo F c/o dizziness that started this morning. She is nauseated and has vomited once in the past day. She had a URI 2 days ago and has experienced no hearing loss. |
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Definition
Vestibular neuronitis Labyrinthitis Ménière’s disease Benign positional vertigo Vertigo associated with cervical spine disease or injury Vertebrobasilar insufficiency * CBC Electrolytes Electronystagmography MRI/MRA—brain |
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Term
55 yo F c/o dizziness that started this morning and of “not hearing well.” She feels nauseated and has vomited once in the past day. She had a URI 2 days ago. |
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Definition
Labyrinthitis Vestibular neuronitis Ménière’s disease Acoustic neuroma Vertebrobasilar insufficiency * Audiogram Electronystagmography MRI/MRA—brain |
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Term
LOSS OF CONSCIOUSNESS Key History Presence or absence of preceding symptoms (nausea, diaphoresis, palpitations, pallor, lightheadedness), context (exertional, postural, traumatic; stressful, painful, or claustrophobic experience; dehydration); associated tongue biting or incontinence, tonic-clonic movements, prolonged confusion; dyspnea or pulmonary embolism risk factors; history of heart disease, arrhythmia, hypertension, or diabetes; alcohol and drug use. |
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Definition
Key Physical Exam Vital signs, including orthostatics; complete neurologic exam; carotid and cardiac exam; lung exam; exam of the lower extremities. |
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Term
26 yo M presents after falling and losing consciousness at work. He had rhythmic movements of the limbs, bit his tongue, and lost control of his bladder. He was subsequently confused after regaining consciousness (as witnessed by his colleagues). |
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Definition
Generalized tonic-clonic seizure Convulsive syncope Substance abuse/overdose Malingering Hypoglycemia * CBC Electrolytes, glucose Urine toxicology EEG MRI—brain CT—head LP—CSF analysis ECG |
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Term
55 yo M c/o falling after feeling dizzy and unsteady. He experienced transient loss of consciousness. His past medical history is significant for hypertension and diabetes mellitus. |
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Definition
Drug-induced orthostatic hypotension (causing syncope) Hypoglycemia Cardiac arrhythmia Syncope (vasovagal, other causes) Stroke MI Pulmonary embolism * Orthostatic vital signs CBC Electrolytes, glucose Echocardiography CT—head ECG V/Q scan CTA—chest with IV contrast D-dimer |
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Term
65 yo M presents after falling and losing consciousness for a few seconds. He had no warning before passing out but recently had palpitations. His history includes a coronary artery bypass graft. |
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Definition
Cardiac arrhythmia (causing syncope) Severe aortic stenosis Syncope (other causes) Seizure Pulmonary embolism * ECG Holter monitoring CBC Electrolytes, glucose Echocardiography CT—head |
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Term
NUMBNESS/WEAKNESS Key History Distribution (unilateral, bilateral, proximal, distal), duration, ± progression, pain (especially headache, neck or back pain); constitutional symptoms, other neurologic symptoms; history of diabetes, alcoholism, atherosclerotic vascular disease. |
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Definition
Key Physical Exam Vital signs; neurologic and musculoskeletal exams; relevant vascular exam. |
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Term
68 yo M presents following a 20-minute episode of slurred speech, right facial drooping and numbness, and right hand weakness. His symptoms had totally resolved by the time he got to the emergency department. He has a history of hypertension, diabetes mellitus, and heavy smoking. |
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Definition
Transient ischemic attack (TIA) Hypoglycemia Seizure Stroke Facial nerve palsy * CT—head CBC Electrolytes, glucose Fasting lipid panel ECG MRI—brain Doppler U/S—carotid Echocardiography EEG |
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Term
68 yo M presents with slurred speech, right facial drooping and numbness, and right hand weakness. Babinski’s sign is present on the right. He has a history of hypertension, diabetes mellitus, and heavy smoking. |
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Definition
Stroke TIA Seizure Intracranial neoplasm Subdural or epidural hematoma * CT—head CBC Electrolytes PT/PTT/INR Fasting lipid panel MRI—brain Doppler U/S—carotid Echocardiography ECG |
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Term
33 yo F presents with ascending loss of strength in her lower legs over the past 2 weeks. She had a recent URI. |
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Definition
Guillain-Barré syndrome Multiple sclerosis Polymyositis Myasthenia gravis Peripheral neuropathy Tumor in the vertebral canal * CBC Electrolytes CPK LP—CSF analysis MRI—spine EMG Nerve conduction studies Tensilon (edrophonium) test Serum B12 |
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Term
30 yo F presents with weakness, loss of sensation, and tingling in her left leg that started this morning. She is also experiencing right eye pain, decreased vision, and double vision. She reports feeling “electric shocks” down her spine upon flexing her head. |
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Definition
Multiple sclerosis Stroke Conversion disorder Malingering CNS tumor Neurosyphilis Syringomyelia CNS vasculitis * CBC ESR VDRL/RPR MRI—brain, spine LP—CSF analysis Retinal evoked potentials |
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Term
55 yo M presents with tingling and numbness in his hands and feet (glove-and-stocking distribution) for the past 2 months. He has a history of diabetes mellitus, hypertension, and alcoholism. There is decreased soft touch, vibratory, and position sense in the feet. |
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Definition
Diabetic peripheral neuropathy Alcoholic peripheral neuropathy B12 deficiency Hypocalcemia Hyperventilation Paraproteinemia/myeloma * HbA1c ESR Calcium Serum B12 UA Serum and urine protein electrophoresis |
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Term
40 yo F presents with occasional double vision and droopy eyelids at night with normalization by morning. |
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Definition
Myasthenia gravis Horner’s syndrome Multiple sclerosis Intracranial neoplasm compressing CN III, IV, or VI Amyotrophic lateral sclerosis * Tensilon (edrophonium) test Serum ACh receptor antibodies CXR CT—chest MRI—brain EMG |
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Term
25 yo M presents with hemiparesis after a tonicclonic seizure that resolved within a few hours. |
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Definition
Todd’s paralysis TIA Stroke Complicated migraine Malingering * CBC Electrolytes EEG MRI—brain Doppler U/S—carotid |
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Term
56 yo obese F c/o tingling and numbness of her thumb, index finger, and middle finger for the past 5 months. Her symptoms are constant, have progressively worsened, and are relieved with rest. She works as a secretary. She has a history of fatigue and a 20-lb (9-kg) weight gain over the same period. |
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Definition
Carpal tunnel syndrome secondary to hypothyroidism Overuse injury of median nerve Medial epicondylitis * Phalen’s maneuver and Tinel’s sign Nerve conduction studies TSH CBC |
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Term
FATIGUE AND SLEEPINESS Key History Duration; sleep hygiene, snoring, waking up choking/gasping, witnessed apnea; overexertion; stress, depression, or other emotional problems; lifestyle changes, shift changes at work; diet, weight changes; other constitutional symptoms; symptoms of thyroid disease; history of bleeding or anemia; medications; alcohol, caffeine, and drug use. |
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Definition
Key Physical Exam Vital signs; ENT exam (conjunctival pallor, oropharynx/palate, lymphadenopathy, thyroid exam); heart, lung, abdominal, neurologic, and extremity (pallor, coolness at distal extremities) exams; consider rectal exam and occult blood testing. |
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Term
40 yo F c/o feeling tired, hopeless, and worthless and of having suicidal thoughts. She lost her job and has been having fights with her husband about money. |
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Definition
Depression Adjustment disorder Hypothyroidism Anemia * CBC TSH HIV/STD testing Beck Depression Inventory |
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Term
44 yo M presents with fatigue, insomnia, and nightmares about a murder that he witnessed in a mall 1 year ago. Since then, he has avoided the mall and has not gone out at night. |
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Definition
Posttraumatic stress disorder Depression Generalized anxiety disorder Psychotic or delusional disorder Hypothyroidism * CBC TSH Urine toxicology Beck Depression Inventory |
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Term
55 yo M presents with fatigue, weight loss, and constipation. He has a family history of colon cancer. |
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Definition
Colon cancer Hypothyroidism Renal failure Hypercalcemia Depression * Rectal exam, stool for occult blood CBC Electrolytes, BUN/Cr, calcium AST/ALT TSH Colonoscopy Barium enema CT—abdomen/pelvis |
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Term
40 yo F presents with fatigue, weight gain, sleepiness, cold intolerance, constipation, and dry skin. |
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Definition
Hypothyroidism Depression Diabetes Anemia * TSH, FT3, FT4 CBC Fasting glucose HbA1c |
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Term
50 yo obese F presents with fatigue and daytime sleepiness. She snores heavily and naps 3–4 times per day but never feels refreshed. She also has hypertension. |
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Definition
Obstructive sleep apnea Hypothyroidism Chronic fatigue syndrome Narcolepsy * CBC TSH Nocturnal pulse oximetry Polysomnography ECG |
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Term
20 yo M presents with fatigue, thirst, increased appetite, and polyuria. |
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Definition
Diabetes mellitus Atypical depression Primary polydipsia Diabetes insipidus * Glucose tolerance test HbA1c UA CBC Electrolytes, BUN/Cr, glucose |
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Term
35 yo M policeman c/o feeling tired and sleepy during the day. He changed to the night shift last week. |
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Definition
Shift work sleep disorder Sleep apnea Depression Anemia * CBC Nocturnal pulse oximetry Polysomnography |
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Term
NIGHT SWEATS Key History Onset, duration, severity, frequency, timing, patterns (escalating, waxing, waning), precipitants (eg, food, medications); associated diseases and symptoms (fever, recent URIs, associated cough, hemoptysis, pleuritic chest pain); lymphadenopathy, rash, malaise, weight loss, itching, diarrhea, nausea/vomiting, early satiety, anorexia; presence of significant risk factors (eg, traveling to areas with endemic infections, IV drug use); alcohol history, sexual exposure, sick contacts, exposure to high-risk populations such as prisoners or homeless people; menstrual history, menopausal status, travel history. |
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Definition
Key Physical Exam Vital signs; HEENT exam, including inspection of the throat and other areas for lymphadenopathy; heart and lung exam; abdominal exam for hepatosplenomegaly; skin exam; musculoskeletal exam for joint pain. |
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Term
30 yo M presents with night sweats, cough, and swollen glands of 1 month’s duration. He recently emigrated from the African subcontinent. |
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Definition
Tuberculosis Acute HIV infection Lymphoma Leukemia Hyperthyroidism * PPD/QuantiFERON Gold CBC CXR Sputum Gram stain, acidfast stain, and culture HIV antibody TSH, FT4 |
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Term
45 yo F presents with excessive sweating, unintentional weight loss, palpitations, diarrhea, and shortness of breath. |
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Definition
Hyperthyroidism Pheochromocytoma Carcinoid syndrome Tuberculosis * TSH, FT4 24-hour urinary catecholamines 5-HIAA CBC PPD |
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Term
INSOMNIA Key History Primary vs. secondary, duration, description (trouble falling asleep vs. multiple awakenings vs. early-morning awakening); daytime sleepiness; other medical problems keeping patient awake at night, such as arthritis (pain) or diabetes (polyuria); evidence of a common sleep disorder (eg, sleep apnea, restless leg syndrome); associated symptoms, including loud snoring, nightmares, and depression; caffeine, alcohol, medication, and recreational drug use; work or lifestyle (jet lag or shift work), stressors, sleep hygiene; presence of psychiatric symptoms (eg, grandiose delusions, irritability). |
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Definition
Key Physical Exam Vital signs; mental status exam; thyroid exam. |
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Term
25 yo F presents with a 3-week history of difficulty falling asleep. She sleeps 7 hours per night without nightmares or snoring. She recently began college and is having trouble with her boyfriend. She drinks 3–4 cups of coffee a day. |
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Definition
Stress-induced insomnia Caffeine-induced insomnia Insomnia with circadian rhythm sleep disorder Insomnia related to major depressive disorder * Polysomnography Mental status exam Urine toxicology CBC TSH |
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Term
55 yo obese M presents with several months of poor sleep, daytime fatigue, and morning headaches. His wife reports that he snores loudly. |
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Definition
Obstructive sleep apnea Daytime fatigue in primary hypersomnia Insomnia with circadian rhythm sleep disorder Insomnia related to major depressive disorder * CBC TSH Polysomnography ECG |
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Term
33 yo F c/o 3 weeks of fatigue and trouble sleeping. She states that she falls asleep easily but wakes up at 3 A.M. and cannot return to sleep. She also reports an unintentional weight loss of 8 lbs (3.6 kg) and an inability to enjoy the things she once liked to do. |
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Definition
Insomnia related to major depressive disorder Primary hypersomnia Insomnia with circadian rhythm sleep disorder * Mental status exam TSH CBC Polysomnography |
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Term
SORE THROAT Key History Duration, fever, other ENT symptoms (ear pain, nasal or sinus congestion), odynophagia, swollen glands, ± cough, rash; sick contacts, HIV risk factors. |
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Definition
Key Physical Exam Vital signs; ENT exam, including oral thrush, tonsillar exudate, and lymphadenopathy; lung, abdominal (focusing on splenomegaly), and skin exams. |
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Term
26 yo F presents with sore throat, fever, severe fatigue, and loss of appetite for the past week. She also reports epigastric and LUQ discomfort. She has cervical lymphadenopathy and a rash. Her boyfriend recently experienced similar symptoms. |
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Definition
Infectious mononucleosis Hepatitis Viral or bacterial pharyngitis Acute HIV infection Secondary syphilis * CBC with peripheral smear Monospot test Throat culture AST/ALT/bilirubin/ alkaline phosphatase HIV antibody and viral load Anti-EBV antibodies VDRL/RPR |
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Term
26 yo M presents with sore throat, fever, rash, and weight loss. He has a history of IV drug abuse and sharing needles. |
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Definition
HIV, acute retroviral syndrome Infectious mononucleosis Hepatitis Viral pharyngitis Streptococcal tonsillitis/ scarlet fever Secondary syphilis * CBC with peripheral smear HIV antibody and viral load CD4 count Monospot test Throat culture VDRL/RPR AST/ALT/bilirubin/ alkaline phosphatase |
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Term
46 yo F presents with fever and sore throat. |
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Definition
Pharyngitis (bacterial or viral) Mycoplasma pneumonia Acute HIV infection Infectious mononucleosis * Throat swab for culture and rapid streptococcal antigen Monospot test CBC Serologic test (cold agglutinin titer) for Mycoplasma HIV antibody and viral load |
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Term
COUGH/SHORTNESS OF BREATH Key History Acute/subacute vs. chronic, increased frequency of cough if chronic, timing; presence/description of sputum, presence of hemoptysis; associated symptoms (constitutional, URI, postnasal drip, dyspnea, wheezing, chest pain, heartburn); exacerbating and alleviating factors, exposures; smoking history; history of lung disease, posttussive emesis, or heart failure; allergies; medications (especially ACE inhibitors). |
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Definition
Key Physical Exam Vital signs ± pulse oximetry; exam of nasal mucosa, oropharynx, heart, lungs, lymph nodes, and extremities (clubbing, cyanosis, edema). |
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Term
30 yo M presents with shortness of breath, cough, and wheezing that worsen in cold air. He has had several such episodes in the past 4 months. |
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Definition
Asthma GERD Bronchitis Pneumonitis Foreign body * CBC CXR Peak flow measurement PFTs Methacholine challenge test |
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Term
56 yo F presents with shortness of breath and a productive cough that has lasted for at least 3 months each year over the past 2 years. She is a heavy smoker. |
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Definition
COPD—chronic bronchitis Bronchiectasis Lung cancer Tuberculosis * CBC Sputum Gram stain and culture CXR PFTs CT—chest PPD |
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Term
58 yo M presents with 1 week of pleuritic chest pain, fever, chills, and cough with purulent yellow sputum. He is a heavy smoker with COPD. |
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Definition
Pneumonia COPD exacerbation (bronchitis) Lung abscess Lung cancer Tuberculosis Pericarditis * CBC Sputum Gram stain and culture CXR CT—chest ECG PPD |
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Term
25 yo F presents with 2 weeks of nonproductive cough. Three weeks ago she had a sore throat and a runny nose. |
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Definition
Atypical pneumonia Reactive airway disease URI-associated cough (“postinfectious”) Postnasal drip GERD * CBC Induced sputum Gram stain and culture CXR IgM detection for Mycoplasma pneumoniae Urine Legionella antigen |
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Term
65 yo M presents with worsening cough for the past 6 months accompanied by hemoptysis, dyspnea, weakness, and weight loss. He is a heavy smoker. |
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Definition
Lung cancer Tuberculosis Lung abscess COPD Vasculitis (eg, Wegener’s granulomatosis) Interstitial lung disease CHF * CBC Sputum Gram stain, culture, and cytology CXR CT—chest PPD ANCA Bronchoscopy Echocardiography |
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Term
55 yo M presents with increased dyspnea and sputum production for the past 3 days. He has COPD and stopped using his inhalers last week. He stopped smoking 2 days ago. |
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Definition
COPD exacerbation (bronchitis) Lung cancer Pneumonia URI CHF * CBC CXR ABG PFTs Sputum Gram stain and culture CT—chest Echocardiography |
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Term
34 yo F nurse presents with worsening cough of 6 weeks’ duration accompanied by weight loss, fatigue, night sweats, and fever. She has a history of contact with tuberculosis patients at work. |
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Definition
Tuberculosis Pneumonia Lung abscess Vasculitis Lymphoma Metastatic cancer HIV/AIDS Sarcoidosis * CBC PPD/QuantiFERON Gold Sputum Gram stain, acidfast stain, and culture CXR CT—chest Bronchoscopy HIV antibody Lymph node biopsy |
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Term
35 yo M presents with shortness of breath and cough. He has had unprotected sex with multiple sexual partners and was recently exposed to a patient with active tuberculosis. |
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Definition
Tuberculosis Pneumonia (including Pneumocystis jiroveci) Bronchitis Asthma Acute HIV infection CHF (cardiomyopathy) * CBC PPD/QuantiFERON Gold Sputum Gram stain, acidfast stain, silver stain, and culture CXR HIV antibody Echocardiography |
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Term
50 yo M presents with a cough that is exacerbated by lying down at night and improved by propping up on 3 pillows. He also reports exertional dyspnea. |
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Definition
CHF Cardiac valvular disease GERD Pulmonary fibrosis COPD Postnasal drip * CBC CXR ECG Echocardiography PFTs BNP CT—chest |
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Term
60 yo M presents with worsening dyspnea of 6 hours’ duration and a cough that is accompanied by pink, frothy sputum. |
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Definition
Pulmonary edema CHF Mitral valve stenosis Arrhythmia Asthma Pneumonia * ECG CXR CBC ABG PFTs BNP |
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Term
CHEST PAIN Key History Location, quality, severity, radiation, duration, context (exertional, postprandial, positional, cocaine use, trauma); associated symptoms (sweating, nausea, dyspnea, palpitations, sense of doom, fever); exacerbating and alleviating factors (especially medications); history of similar symptoms; known heart or lung disease or history of diagnostic testing; cardiac risk factors (hypertension, hyperlipidemia, smoking, family history of early MI); pulmonary embolism risk factors (history of DVT, coagulopathy, malignancy, recent immobilization). |
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Definition
Key Physical Exam Vital signs ± BP in both arms; complete cardiovascular exam (JVD, PMI, chest wall tenderness, heart sounds, pulses, edema); lung and abdominal exams; lower extremity exam (inspection for signs of DVT). |
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Term
60 yo M presents with sudden onset of substernal heavy chest pain that has lasted for 30 minutes and radiates to the left arm. The pain is accompanied by dyspnea, diaphoresis, and nausea. He has a history of hypertension, hyperlipidemia, and smoking. |
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Definition
Myocardial infarction (MI) GERD Angina Costochondritis Aortic dissection Pericarditis Pulmonary embolism Pneumothorax * ECG CPK-MB, troponin × 3 CXR CBC Electrolytes Echocardiography Cardiac catheterization D-dimer Helical CT |
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Term
20 yo African American F presents with acute onset of severe chest pain for a few hours. She has a history of sickle cell disease and multiple hospitalizations for pain and anemia management. |
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Definition
Sickle cell disease—acute chest syndrome Pulmonary embolism Pneumonia MI Pneumothorax Aortic dissection * CBC with reticulocyte count and peripheral smear LDH ABG D-dimer CXR CPK-MB, troponin ECG CTA—chest with IV contrast |
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Term
45 yo F presents with a retrosternal burning sensation that occurs after heavy meals and when lying down. Her symptoms are relieved by antacids |
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Definition
GERD Esophagitis Peptic ulcer disease Esophageal spasm MI Angina * ECG Barium swallow Upper endoscopy Esophageal pH monitoring |
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Term
55 yo M presents with retrosternal squeezing pain that lasts for 2 minutes and occurs with exercise. It is relieved by rest and is not related to food intake. |
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Definition
Stable angina Esophageal spasm Esophagitis * ECG CPK-MB, troponin CXR CBC Electrolytes Exercise stress test Upper endoscopy/pH monitor Cardiac catheterization |
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Term
34 yo F presents with retrosternal stabbing chest pain that improves when she leans forward and worsens with deep inspiration. She had a URI 1 week ago. |
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Definition
Pericarditis Aortic dissection MI Costochondritis GERD Esophageal rupture * ECG CPK-MB, troponin CXR Echocardiography CBC Upper endoscopy ESR |
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Term
33 yo F presents with stabbing chest pain that worsens with deep inspiration and is relieved by aspirin. She had a URI 1 week ago. Chest wall tenderness is noted. |
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Definition
Costochondritis Pneumonia MI Pulmonary embolism Pericarditis Pleurisy Muscle strain * ECG CPK-MB, troponin CXR CBC |
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Term
70 yo F presents with acute onset of shortness of breath at rest and pleuritic chest pain. She also presents with tachycardia, hypotension, tachypnea, and mild fever. She is recovering from hip replacement surgery. |
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Definition
Pulmonary embolism Pneumonia Costochondritis MI CHF Aortic dissection * D-dimer ECG CXR ABG CPK-MB, troponin CBC Electrolytes, BUN/Cr, glucose CTA—chest with IV contrast Doppler U/S—legs |
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Term
55 yo M presents with sudden onset of severe chest pain that radiates to his back. He has a history of uncontrolled hypertension. |
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Definition
Aortic dissection MI Pericarditis Esophageal rupture Esophageal spasm GERD Pancreatitis Fat embolism * ECG CPK-MB, troponin CXR CBC Amylase, lipase CTA—chest with IV contrast Transesophageal echocardiography (TEE) MRI/MRA—aorta Aortic angiography Upper endoscopy |
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Term
PALPITATIONS Key History Gradual vs. acute onset/offset, context (exertion, caffeine, anxiety); associated symptoms (lightheadedness, loss of consciousness, chest pain, dyspnea, fever, sweating, pale skin, flushing, diarrhea); hyperthyroid symptoms; history of bleeding or anemia; history of heart disease, hypertension, or diabetes. |
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Definition
Key Physical Exam Vital signs; endocrine/thyroid exam, including exophthalmos, lid retraction, lid lag, gland size, bruit, and tremor; complete cardiovascular exam. |
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Term
70 yo diabetic M presents with episodes of palpitations and diaphoresis. He is on insulin. |
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Definition
Hypoglycemia Cardiac arrhythmia Angina Hyperthyroidism Hyperventilation episodes Panic attack Pheochromocytoma Carcinoid syndrome * Glucose CBC Electrolytes TSH ECG Holter monitor 24-hour urinary catecholamines 5-HIAA |
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Term
35 yo M presents with several episodes of palpitations, sweating, and rapid breathing. Episodes occur unexpectedly, and he does not recall any triggers. He has had 4–5 episodes per month for several months. Each episode lasts 2–3 minutes. He does not have any history of psychiatric illness except for separation anxiety as a child. |
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Definition
Panic attack Generalized anxiety disorder Acute stress disorder Specific phobia Hyperthyroidism Agoraphobia Substance abuse/ dependence Mitral valve prolapse Pheochromocytoma * CBC Electrolytes TSH, FT4 ECG Echocardiography Urine toxicology 24-hour urinary catecholamines |
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Term
19 yo F presents with episodic palpitations, especially during presentations in front of her class. Episodes include heart pounding, facial blushing, and hand tremor. She also experiences excessive sweating and rapid breathing. She complains of intense worry and trouble sleeping for days or weeks before an upcoming social situation. Now she avoids all social events because she is afraid of humiliating herself. |
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Definition
Social phobia Avoidant personality disorder Agoraphobia/specific phobia Panic attack Generalized anxiety disorder Substance abuse/ dependence Hyperthyroidism * CBC Electrolytes ECG Echocardiography TSH, FT4 Mental status exam |
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Term
34 yo F presents with episodic palpitations accompanied by lightheadedness and sharp, atypical chest pain. |
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Definition
Mitral valve prolapse Cardiac arrhythmia Panic attack Pheochromocytoma * ECG Echocardiography Holter monitor 24-hour urinary catecholamines |
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Term
WEIGHT LOSS Key History Amount, duration, ± intention; diet and exercise history; body image, anxiety or depression; other constitutional symptoms; hyperthyroid symptoms (palpitations, tremor, diarrhea); family history of thyroid disease; HIV risk factors; tobacco, alcohol, and drug use; medications; history of cancer; blood in urine or stool. |
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Definition
Key Physical Exam Vital signs; complete physical. |
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Term
42 yo F presents with a 15.5-lb (7-kg) weight loss within the past 2 months. She has a fine tremor, and her pulse is 112. |
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Definition
Hyperthyroidism Cancer HIV infection Dieting/diet drugs Anorexia nervosa Malabsorption * TSH, FT4 CBC Electrolytes HIV antibody Urine toxicology |
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Term
WEIGHT GAIN Key History Amount, duration, timing (relation to medication changes, smoking cessation, depression); diet history; hypothyroid symptoms (fatigue, constipation, skin/hair/nail changes); menstrual irregularity, hirsutism; medical history; alcohol and drug use. |
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Definition
Key Physical Exam Vital signs; complete exam, including signs of Cushing’s syndrome (hypertension, central obesity, moon face, buffalo hump, supraclavicular fat pads, purple abdominal striae); edema resulting from water retention in renal disease. |
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Term
44 yo F presents with a weight gain of > 25 lbs (11.3 kg) within the past 2 months. She quit smoking 3 months ago and is on amitriptyline for depression. She also reports cold intolerance and constipation. |
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Definition
Smoking cessation Drug side effect Hypothyroidism Cushing’s syndrome Polycystic ovary syndrome Diabetes mellitus Atypical depression * CBC Electrolytes, glucose TSH 24-hour urine free cortisol Dexamethasone suppression test |
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Term
30 yo F presents with weight gain over the past 3 months. She also reports tremor, palpitations, anxiety, and hunger that is relieved by eating. She exhibits proximal muscle weakness and easy bruising. |
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Definition
Insulinoma Reactive postprandial hypoglycemia Cushing’s syndrome * Blood glucose and plasma insulin Glucose tolerance test 24-hour urine free cortisol |
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Term
DYSPHAGIA Key History Solids or liquids vs. both solids and liquids, ± progression, occurring at the beginning or middle of swallow; constitutional symptoms (especially weight loss); hoarseness, drooling, regurgitation of liquids vs. undigested food, odynophagia, GERD symptoms; medications; HIV risk factors; history of anxiety, smoking, Raynaud’s phenomenon. |
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Definition
Key Physical Exam Vital signs; head and neck exam; heart, lung, and abdominal exams; skin exam (for signs of scleroderma/CREST). |
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Term
75 yo M presents with dysphagia that started with solids and progressed to liquids. He is an alcoholic and a heavy smoker. He has had an unintentional weight loss of 15 lbs (6.8 kg) within the past 4 months. |
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Definition
Esophageal cancer Achalasia Esophagitis Systemic sclerosis Esophageal stricture Amyotrophic lateral sclerosis * CBC CXR Upper endoscopy with biopsy Barium swallow CT—chest |
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Term
45 yo F presents with dysphagia for 2 weeks accompanied by mouth and throat pain, fatigue, and a craving for ice and clay. |
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Definition
Plummer-Vinson syndrome Esophageal cancer Esophagitis Achalasia Systemic sclerosis Mitral valve stenosis * CBC Serum iron, ferritin, TIBC Barium swallow Upper endoscopy Video fluoroscopy |
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Term
48 yo F presents with dysphagia for both solids and liquids that has slowly progressed in severity within the past year. It is associated with difficulty belching and regurgitation of undigested food, especially at night. She has lost 5.5 lbs (2.5 kg) in the past 2 months. |
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Definition
Achalasia Plummer-Vinson syndrome Esophageal cancer Esophagitis Systemic sclerosis Mitral valve stenosis Esophageal stricture Zenker’s diverticulum * CXR Upper endoscopy Barium swallow Esophageal manometry XR—neck |
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Term
38 yo M presents with dysphagia and pain on swallowing solids more than liquids. Exam reveals oral thrush. |
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Definition
Esophagitis (CMV, HSV, HIV, pill-induced) Systemic sclerosis GERD Esophageal stricture Zenker’s diverticulum * CBC Upper endoscopy Barium swallow HIV antibody and viral load CD4 count |
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Term
NECK MASS Key History Onset, size, location, mobility, pain, movement with swallowing; obstructive symptoms (dysphagia, shortness of breath); other masses; associated symptoms (constitutional, hematologic, GI, endocrine, pulmonary); ill contacts. |
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Definition
Key Physical Exam Vital signs; HEENT exam; exam of lymph nodes, spleen, and tonsils; heart, lung, and abdominal exams. |
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Term
39 yo F presents with a single 2-cm mass on the right side of her neck along with night sweats, fever, weight loss, loss of appetite, and early satiety. The mass is painless and movable and has not changed in size. She does not report heat intolerance, tremor, palpitations, hoarseness, cough, difficulty breathing, difficulty swallowing, or abdominal pain. Her husband was recently discharged from prison, and her mother has a history of gastric cancer. |
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Definition
Hodgkin’s/non- Hodgkin’s lymphoma Tuberculosis Thyroid nodule Gastric carcinoma * CBC with differential Electrolytes ESR, CRP Lymph node biopsy PPD CXR TSH U/S—thyroid Upper endoscopy |
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Term
NAUSEA/VOMITING Key History Acuity of onset, ± abdominal pain, relation to meals, sick contacts, possible food poisoning, possible pregnancy; neurologic symptoms (headache, stiff neck, vertigo, focal numbness or weakness); urinary symptoms; other associated symptoms (GI, chest pain); exacerbating and alleviating factors; medications; history of prior abdominal surgery. |
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Definition
Key Physical Exam Vital signs; ENT; consider funduscopic exam (increased intracranial pressure); complete abdominal exam; consider heart, lung, and rectal exams. |
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Term
20 yo F presents with nausea, vomiting (especially in the morning), fatigue, and polyuria. Her last menstrual period was 6 weeks ago, and her breasts are full and tender. She is sexually active with her boyfriend, and they occasionally use condoms for contraception. |
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Definition
Pregnancy Gastritis Hypercalcemia Diabetes mellitus UTI Depression * Urine hCG Pelvic exam U/S—pelvis CBC Electrolytes, calcium, glucose UA, urine culture HIV antibody |
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Term
ABDOMINAL PAIN Key History Location, quality, intensity, duration, radiation, timing (relation to meals); associated symptoms (constitutional, GI, cardiac, pulmonary, renal, pelvic); exacerbating and alleviating factors; history of similar symptoms; history of abdominal surgeries, trauma, gallstones, renal stones, atherosclerotic vascular disease; medications (eg, NSAIDs, corticosteroids); alcohol and drug use; domestic violence, stress/anxiety, sexual history, pregnancy history. |
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Definition
Key Physical Exam Vital signs; heart and lung exams; abdominal exam, including tenderness, guarding, rebound, Murphy’s sign, psoas and obturator signs, and CVA percussion; bowel sounds, aortic bruits; rectal exam; pelvic exam (women). |
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Term
45 yo M presents with sudden onset of colicky rightsided flank pain that radiates to the testicles, accompanied by nausea, vomiting, hematuria, and CVA tenderness. |
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Definition
Nephrolithiasis Renal cell carcinoma Pyelonephritis GI etiology (eg, appendicitis) * UA, urine culture and sensitivity, urine cytology BUN/Cr CT—abdomen U/S—renal KUB IVP Blood culture |
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Term
60 yo M presents with dull epigastric pain that radiates to the back, accompanied by weight loss, dark urine, and clay-colored stool. He is a heavy drinker and smoker. He appears jaundiced on exam. |
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Definition
Pancreatic cancer Cholangiocarcinoma Acute viral hepatitis Acute alcoholic hepatitis Chronic pancreatitis Cholecystitis/ choledocholithiasis Abdominal aortic aneurysm Peptic ulcer disease * CBC Electrolytes Amylase, lipase AST/ALT/bilirubin/ alkaline phosphatase CT—abdomen U/S—abdomen |
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Term
56 yo M presents with severe midepigastric abdominal pain that radiates to the back and improves when he leans forward. He also reports anorexia, nausea, and vomiting. He is an alcoholic and has spent the past 3 days binge drinking. |
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Definition
Acute pancreatitis Peptic ulcer disease Cholecystitis/ choledocholithiasis Gastritis Abdominal aortic aneurysm Mesenteric ischemia Alcoholic hepatitis Boerhaave syndrome * CBC Electrolytes, BUN/Cr Amylase, lipase AST/ALT/bilirubin/ alkaline phosphatase U/S—abdomen CT—abdomen Upper endoscopy ECG |
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Term
41 yo obese F presents with RUQ abdominal pain that radiates to the right scapula and is associated with nausea, vomiting, and a fever of 101.5°F. The pain started after she ate fatty food. She has had similar but less intense episodes that lasted a few hours. Exam reveals a positive Murphy’s sign. |
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Definition
Acute cholecystitis Choledocholithiasis Hepatitis Ascending cholangitis Peptic ulcer disease Fitz-Hugh–Curtis syndrome Acute subhepatic appendicitis * CBC AST/ALT/bilirubin/ alkaline phosphatase U/S—abdomen CT—abdomen Blood culture |
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Term
43 yo obese F presents with RUQ abdominal pain, fever, and jaundice. She was diagnosed with asymptomatic gallstones 1 year ago. She is found to be hypotensive on exam. |
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Definition
Ascending cholangitis Acute gallstone cholangitis Acute cholecystitis Hepatitis Sclerosing cholangitis Fitz-Hugh–Curtis syndrome * CBC AST/ALT/bilirubin/ alkaline phosphatase Blood culture Viral hepatitis serologies U/S—abdomen MRCP ERCP |
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Term
25 yo M presents with RUQ pain, fever, anorexia, nausea, and vomiting. He has dark urine and claycolored stool. |
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Definition
Acute hepatitis Acute cholecystitis Ascending cholangitis Choledocholithiasis Pancreatitis Acute glomerulonephritis * CBC Amylase, lipase AST/ALT/bilirubin/ alkaline phosphatase Viral hepatitis serologies UA U/S—abdomen |
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Term
35 yo M presents with burning epigastric pain that starts 2–3 hours after meals. The pain is relieved by food and antacids. |
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Definition
Peptic ulcer disease Gastritis GERD Cholecystitis Chronic pancreatitis Mesenteric ischemia * Rectal exam, stool for occult blood Amylase, lipase, lactate AST/ALT/bilirubin/ alkaline phosphatase Upper endoscopy (including H pylori testing) Upper GI series |
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Term
37 yo M presents with severe epigastric pain, nausea, vomiting, and mild fever. He appears toxic. He has a history of intermittent epigastric pain that is relieved by food and antacids. He also smokes heavily and takes aspirin on a daily basis. |
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Definition
Perforated peptic ulcer Acute pancreatitis Hepatitis Cholecystitis Gallstone cholangitis Mesenteric ischemia * Rectal exam CBC Electrolytes Amylase, lipase, lactate AST/ALT/bilirubin/ alkaline phosphatase CXR KUB CT—abdomen Upper endoscopy (including H pylori testing) Blood culture |
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Term
18 yo M boxer presents with severe LUQ abdominal pain that radiates to the left scapula. He had infectious mononucleosis 3 weeks ago. |
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Definition
Splenic rupture Kidney stone Rib fracture Pneumonia Perforated peptic ulcer Splenic infarct * CBC Electrolytes CXR CT—abdomen U/S—abdomen (if hemodynamically unstable) |
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Term
40 yo M presents with crampy abdominal pain, vomiting, abdominal distention, and inability to pass flatus or stool. He has a history of multiple abdominal surgeries. |
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Definition
Intestinal obstruction Small bowel or colon cancer Volvulus Gastroenteritis Food poisoning Ileus Hernia * Rectal exam CBC Electrolytes AXR CT—abdomen/pelvis with contrast Colonoscopy |
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Term
70 yo F presents with acute onset of severe, crampy abdominal pain. She recently vomited and had a massive dark bowel movement. She has a history of CHF and atrial fibrillation, for which she has received digitalis. Her pain is out of proportion to the exam. |
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Definition
Mesenteric ischemia/ infarction Diverticulitis Peptic ulcer disease Gastroenteritis Acute pancreatitis Cholecystitis * Rectal exam CBC Amylase, lipase, lactate ECG AXR CT—abdomen Mesenteric angiography Barium enema |
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Term
21 yo F presents with acute onset of severe RLQ pain, nausea, and vomiting. She has no fever, urinary symptoms, or vaginal bleeding and has never taken OCPs. Her last menstrual period was regular, and she has no history of STDs. She has been told that she had a cyst on her right ovary. |
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Definition
Ovarian torsion Appendicitis Nephrolithiasis Ectopic pregnancy Ruptured ovarian cyst Pelvic inflammatory disease Bowel infarction or perforation * Pelvic exam Urine hCG Doppler U/S—pelvis Rectal exam UA CBC CT—abdomen Laparoscopy Chlamydia and gonorrhea testing, VDRL/RPR |
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Term
68 yo M presents with LLQ abdominal pain, fever, and chills for the past 3 days. He also reports recent onset of alternating diarrhea and constipation. He consumes a low-fiber, high-fat diet. |
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Definition
Diverticulitis Crohn’s disease Ulcerative colitis Gastroenteritis Abscess * Rectal exam CBC Electrolytes CXR AXR CT—abdomen Blood culture |
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Term
20 yo M presents with severe RLQ abdominal pain, nausea, and vomiting. His discomfort started yesterday as a vague pain around the umbilicus. As the pain worsened, it became sharp and migrated to the RLQ. McBurney’s and psoas signs are positive. |
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Definition
Acute appendicitis Gastroenteritis Diverticulitis Crohn’s disease Nephrolithiasis Volvulus or other intestinal obstruction Perforation Acute cholecystitis * CBC Electrolytes CT—abdomen AXR U/S—abdomen Blood culture |
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Term
30 yo F presents with periumbilical pain for 6 months. The pain never awakens her from sleep. It is relieved by defecation and worsens when she is upset. She has alternating constipation and diarrhea but no nausea, vomiting, weight loss, or anorexia |
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Definition
Irritable bowel syndrome Crohn’s disease Celiac disease Chronic pancreatitis GI parasitic infection (amebiasis, giardiasis) Endometriosis * Rectal exam, stool for occult blood Pelvic exam Urine hCG CBC Electrolytes Colonoscopy CT—abdomen/pelvis Stool for ova and parasitology, Entamoeba histolytica antigen |
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Term
24 yo F presents with bilateral lower abdominal pain that started with the first day of her menstrual period. The pain is associated with fever and a thick, greenish-yellow vaginal discharge. She has had unprotected sex with multiple sexual partners. |
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Definition
Pelvic inflammatory disease Endometriosis Dysmenorrhea Vaginitis Cystitis Spontaneous abortion Pyelonephritis * Pelvic exam Urine hCG Cervical cultures CBC ESR UA, urine culture U/S—pelvis |
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Term
CONSTIPATION/DIARRHEA Key History Frequency, color, odor, and volume of stools; presence of mucus or flatulence; whether stools float in bowl; duration of change in bowel habits; associated symptoms (constitutional, abdominal pain, bloating, tenesmus, sense of incomplete evacuation, melena or hematochezia); thyroid disease symptoms (eg, feeling hot, palpitations, weight loss); diet (especially fiber and fluid intake); medications (including recent antibiotics); sick contacts, travel, camping, HIV risk factors; history of abdominal surgeries, diabetes, pancreatitis; alcohol and drug use; family history of colon cancer. |
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Definition
Key Physical Exam Vital signs; relevant thyroid/endocrine exam; abdominal and rectal exams; ± female pelvic exam. |
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Term
67 yo M presents with alternating diarrhea and constipation, decreased stool caliber, and blood in the stool for the past 8 months. He also reports unintentional weight loss. He is on a low-fiber diet and has a family history of colon cancer. His last colonoscopy was 12 years ago. |
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Definition
Colorectal cancer Irritable bowel syndrome Diverticulosis GI parasitic infection (ascariasis, giardiasis) Inflammatory bowel disease * Rectal exam, stool for occult blood CBC Electrolytes AST/ALT/bilirubin/ alkaline phosphatase Colonoscopy Barium enema CT—abdomen/pelvis |
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Term
28 yo M presents with constipation (hard stool) for the past 3 weeks. Since his mother died 2 months ago, he and his father have eaten only junk food. |
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Definition
Low-fiber diet Depression Substance abuse (eg, heroin) Irritable bowel syndrome Hypothyroidism * Rectal exam TSH Electrolytes Urine toxicology |
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Term
30 yo F presents with alternating constipation and diarrhea accompanied by abdominal pain that is relieved by defecation. She has no nausea, vomiting, weight loss, or blood in her stool. |
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Definition
Irritable bowel syndrome Inflammatory bowel disease Celiac disease Chronic pancreatitis GI parasitic infection (ascariasis, giardiasis) Lactose intolerance * Rectal exam, stool for occult blood CBC Electrolytes Colonoscopy Stool for ova and parasitology CT—abdomen/pelvis |
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Term
33 yo M presents with watery diarrhea, vomiting, and diffuse abdominal pain that began yesterday. He also reports feeling hot. Several of his coworkers are also ill. |
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Definition
Infectious diarrhea (gastroenteritis)— bacterial, viral, parasitic, protozoal Food poisoning * Rectal exam, stool for occult blood Stool leukocytes and culture CBC Electrolytes CT—abdomen/pelvis |
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Term
40 yo F presents with watery diarrhea and abdominal cramps. Last week she was on antibiotics for a UTI. |
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Definition
Pseudomembranous (Clostridium difficile) colitis Gastroenteritis Cryptosporidiosis Food poisoning Inflammatory bowel disease * Stool for C difficile toxin Rectal exam, stool for occult blood Stool leukocytes and culture CBC Electrolytes |
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Term
25 yo M presents with watery diarrhea and abdominal cramps. He was recently in Mexico. |
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Definition
Traveler’s diarrhea Giardiasis Amebiasis Food poisoning Hepatitis A * Rectal exam Stool leukocytes, culture, Giardia antigen, Entamoeba histolytica antigen CBC Electrolytes AST/ALT/bilirubin/ alkaline phosphatase Viral hepatitis serologies |
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Term
30 yo F presents with watery diarrhea, abdominal cramping, and bloating. Her symptoms are aggravated by milk ingestion and are relieved by fasting. |
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Definition
Lactose intolerance Gastroenteritis Inflammatory bowel disease Irritable bowel syndrome Hyperthyroidism * Rectal exam Stool leukocytes and culture Hydrogen breath test TSH |
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Term
33 yo M presents with watery diarrhea, diffuse abdominal pain, and weight loss within the past 3 weeks. He has a history of aphthous ulcers. He has not responded to antibiotics. |
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Definition
Crohn’s disease Gastroenteritis Ulcerative colitis Celiac disease Pseudomembranous colitis Hyperthyroidism Small bowel lymphoma Carcinoid syndrome * Rectal exam, stool for occult blood Stool leukocytes and culture CBC Electrolytes Colonoscopy CT—abdomen TSH Small bowel series 5-HIAA |
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Term
UPPER GI BLEEDING Key History Amount, duration, context (after severe vomiting, alcohol ingestion, nosebleed); associated symptoms (constitutional, nausea, abdominal pain, dyspepsia); medications (especially blood thinners, NSAIDs, and corticosteroids); history of peptic ulcer disease, liver disease, abdominal aortic aneurysm repair, easy bleeding. |
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Definition
Key Physical Exam Vital signs, including orthostatics; ENT, heart, lung, abdominal, and rectal exams. |
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Term
45 yo F presents with coffee-ground emesis for the past 3 days. Her stool is dark and tarry. She has a history of intermittent epigastric pain that is relieved by food and antacids. |
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Definition
Bleeding peptic ulcer Gastritis Gastric cancer Esophageal varices * Rectal exam CBC, type and cross Electrolytes AST/ALT/bilirubin/ alkaline phosphatase INR Upper endoscopy (including H pylori testing if ulcer is confirmed) |
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Term
40 yo F presents with epigastric pain and coffeeground emesis. She has a history of rheumatoid arthritis that has been treated with NSAIDs. She is an alcoholic. |
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Definition
Gastritis Bleeding peptic ulcer Gastric cancer Esophageal varices Mallory-Weiss tear * Rectal exam CBC, type and cross Electrolytes AST/ALT/bilirubin/ alkaline phosphatase INR Upper endoscopy |
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Term
BLOOD IN STOOL Key History Melena vs. bright red blood; amount, duration; associated symptoms (constitutional, abdominal or rectal pain, tenesmus, constipation/diarrhea); menstrual cycle; trauma; history of similar symptoms; prior colonoscopy; medications (especially blood thinners); history of easy bleeding or atherosclerotic vascular disease, renal disease, aortic valve disease, liver disease, alcoholism, or abdominal aortic aneurysm repair; family history of colon cancer. |
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Definition
Key Physical Exam Vital signs ± orthostatics; abdominal and rectal exams. |
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Term
67 yo M presents with blood in his stool, weight loss, and constipation. He has a family history of colon cancer. |
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Definition
Colorectal cancer Anal fissure Hemorrhoids Diverticulosis Ischemic bowel disease Angiodysplasia Upper GI bleeding Inflammatory bowel disease * Rectal exam CBC AST/ALT/bilirubin/ alkaline phosphatase INR Colonoscopy CEA CT—abdomen/pelvis |
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Term
33 yo F presents with rectal bleeding and diarrhea for the past week. She has had lower abdominal pain and tenesmus for several months. |
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Definition
Ulcerative colitis Crohn’s disease Proctitis Anal fissure Hemorrhoids Diverticulosis Dysentery * Rectal exam CBC PT/PTT Colonoscopy CT—abdomen/pelvis |
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Term
58 yo M presents with painless bright red blood per rectum and chronic constipation. He consumes a low-fiber diet. |
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Definition
Diverticulosis Anal fissure Hemorrhoids Angiodysplasia Colorectal cancer * Rectal exam CBC, type and cross PT/PTT Electrolytes Colonoscopy Tagged RBC scan CT—abdomen/pelvis |
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Term
HEMATURIA Key History Amount, duration, ± clots; associated symptoms (constitutional, renal colic, dysuria, irritative voiding symptoms); point along the stream (initial vs. terminal vs. throughout); medications; history of vigorous exercise, trauma, smoking, stones, cancer, or easy bleeding; skin bruising (purpura). |
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Definition
Key Physical Exam Vital signs; lymph nodes; abdominal exam; genitourinary and rectal exams; extremities. |
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Term
65 yo M presents with painless hematuria. He is a heavy smoker and works as a painter. |
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Definition
Bladder cancer Renal cell carcinoma Nephrolithiasis Acute glomerulonephritis Prostate cancer Coagulation disorder (ie, factor VIII antibodies) * Genitourinary exam UA, urine cytology BUN/Cr PSA CBC PT/PTT Cystoscopy U/S—renal/bladder CT—abdomen/pelvis Prostate biopsy |
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Term
35 yo M presents with painless hematuria. He has a family history of kidney disease. |
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Definition
Polycystic kidney disease Nephrolithiasis Acute glomerulonephritis (eg, IgA nephropathy) UTI Coagulation disorder Bladder cancer * Genitourinary exam UA, urine cytology BUN/Cr PSA CBC PT/PTT U/S—renal CT—abdomen/pelvis |
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Term
55 yo M presents with flank pain and blood in his urine without dysuria. He has experienced weight loss and fever over the past 2 months. Exam reveals a flank mass. |
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Definition
Renal cell carcinoma Bladder cancer Nephrolithiasis Acute glomerulonephritis Pyelonephritis Prostate cancer * Genitourinary, rectal exams UA, urine cytology BUN/Cr PSA CBC PT/PTT U/S—renal CT—abdomen/pelvis Cystoscopy |
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Term
OTHER URINARY SYMPTOMS Key History Duration, obstructive symptoms (hesitancy, diminished stream, sense of incomplete bladder emptying, straining, postvoid dribbling, leakage with cough or sneeze, incontinence), irritative symptoms (urgency, frequency, nocturia), constitutional symptoms; bone pain; medications; history of UTIs, urethral stricture, or urinary tract instrumentation; stones, diabetes, alcoholism. |
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Definition
Key Physical Exam Vital signs; abdominal exam (including suprapubic percussion to assess for a distended bladder); genital and rectal exams; focused neurologic exam. |
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Term
60 yo M presents with nocturia, urgency, weak stream, and terminal dribbling. He denies any weight loss, fatigue, or bone pain. He has had 2 episodes of urinary retention that required catheterization. |
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Definition
Benign prostatic hypertrophy (BPH) Prostate cancer UTI Bladder stones * Rectal exam UA CBC BUN/Cr Alkaline phosphatase U/S—prostate (transrectal) PSA |
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Term
71 yo M presents with nocturia, urgency, a weak stream, terminal dribbling, hematuria, and lower back pain for the past 4 months. He has also experienced weight loss and fatigue. |
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Definition
Prostate cancer BPH Renal cell carcinoma UTI * Rectal exam UA CBC BUN/Cr PSA U/S—prostate (transrectal) Prostate biopsy Alkaline phosphatase CT—pelvis MRI—spine Bladder stones |
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Term
18 yo M presents with a burning sensation during urination and urethral discharge. He recently had unprotected sex with a new partner. |
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Definition
Urethritis Cystitis Prostatitis * Genital, rectal exams UA, urine culture Gram stain and culture of urethral discharge Chlamydia and gonorrhea PCR |
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Term
45 yo diabetic F presents with dysuria, urinary frequency, fever, chills, and nausea for the past 3 days. There is left CVA tenderness on exam. |
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Definition
Acute pyelonephritis Nephrolithiasis Lower UTI (cystitis, urethritis) Renal cell carcinoma * UA, urine culture and sensitivity Blood culture CBC BUN/Cr U/S—renal CT—abdomen |
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Term
55 yo F presents with urinary leakage after exercise. She loses a small amount of urine when she coughs, laughs, or sneezes. She also complains of vague low back pain. She has a history of multiple vaginal deliveries, and her mother had the same problem after the onset of menopause. |
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Definition
Stress incontinence Mixed incontinence Urge incontinence Overflow incontinence Functional incontinence UTI Diabetes mellitus * UA, urine culture BUN/Cr Urodynamic testing IVP Cystourethroscopy |
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Term
33 yo F presents with urinary leakage. She is unable to suppress the urge to urinate and loses large amounts of urine without warning. She has a history of UTIs and a family history of diabetes mellitus. She drinks 8 cups of coffee per day. She has been under stress since her sister passed away a few months ago. |
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Definition
Urge incontinence Mixed incontinence Stress incontinence Overflow incontinence Functional incontinence UTI Diabetes mellitus * CBC Electrolytes, BUN/Cr, glucose UA, urine culture Urodynamic testing IVP Cystourethroscopy |
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Term
ERECTILE DYSFUNCTION (ED) Key History Duration, severity, ± nocturnal erections, libido, stress or depression, trauma, associated incontinence; gynecomastia or loss of body hair; medications (and recent changes); medical history (hypertension, diabetes, high cholesterol, known atherosclerotic vascular disease, prior prostate surgery, liver disease, thyroid disease, neurologic disease); smoking, alcohol, and drug use. |
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Definition
Key Physical Exam Vital signs; cardiovascular exam; genital and rectal exams. |
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Term
47 yo M presents with impotence that started 3 months ago. He has hypertension and was started on atenolol 4 months ago. He also has diabetes and is on insulin. |
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Definition
Drug-related ED ED caused by hypertension ED caused by diabetes mellitus Psychogenic ED Peyronie’s disease * Genital exam Rectal exam Glucose CBC Testosterone level |
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Term
AMENORRHEA Key History Primary vs. secondary, duration, possible pregnancy; associated symptoms (headache, decreased peripheral vision, galactorrhea, hirsutism, virilization, hot flashes, vaginal dryness, symptoms of thyroid disease); history of anorexia nervosa, excessive dieting, vigorous exercise, pregnancies, D&Cs, uterine infections; drug use; medications. |
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Definition
Key Physical Exam Vital signs; breast exam; complete pelvic exam. |
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Term
40 yo F presents with amenorrhea, morning nausea and vomiting, fatigue, and polyuria. Her last menstrual period was 6 weeks ago, and her breasts are full and tender. She uses the rhythm method for contraception. |
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Definition
Pregnancy Anovulatory cycle Hyperprolactinemia UTI Hypothyroidism * Urine hCG U/S—abdomen/pelvis Pelvic exam CBC UA, urine culture Prolactin, TSH Baseline Pap smear, cervical cultures, rubella antibody, HIV antibody, hepatitis B surface antigen, VDRL/ RPR |
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Term
23 yo obese F presents with amenorrhea for 6 months, facial hair, and infertility for the past 3 years. |
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Definition
Polycystic ovary syndrome Thyroid disease Hyperprolactinemia Pregnancy Ovarian or adrenal malignancy Premature ovarian failure * Urine hCG LH/FSH, TSH, prolactin Pelvic exam Testosterone, DHEAS |
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Term
35 yo F presents with amenorrhea, galactorrhea, visual field defects, and headaches for the past 6 months. |
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Definition
Amenorrhea secondary to prolactinoma Pregnancy Thyroid disease Premature ovarian failure Pituitary tumor * Urine hCG LH/FSH, TSH, prolactin MRI—brain Pelvic and breast exams |
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Term
48 yo F presents with amenorrhea for the past 6 months accompanied by hot flashes, night sweats, emotional lability, and dyspareunia. |
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Definition
Menopause Pregnancy Pituitary tumor Thyroid disease * Urine hCG LH/FSH, TSH, prolactin Testosterone, DHEAS Pelvic exam CBC MRI—brain |
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Term
35 yo F presents with amenorrhea, cold intolerance, coarse hair, weight loss, and fatigue. She has a history of abruptio placentae followed by hypovolemic shock and failure of lactation 2 years ago. |
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Definition
Sheehan’s syndrome Premature ovarian failure Pituitary tumor Thyroid disease Asherman’s syndrome * Urine hCG LH/FSH, prolactin CBC Pelvic exam TSH, FT4 ACTH MRI—brain Hysteroscopy |
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Term
18 yo F presents with amenorrhea for the past 4 months. She is 5 feet, 6 inches (167.6 cm) and weighs 90 lbs (40.9 kg). She has a history of exercise and heat intolerance. |
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Definition
Anorexia nervosa Pregnancy Hyperthyroidism * Urine hCG CBC TSH, FT4 LH/FSH |
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Term
29 yo F presents with amenorrhea for the past 6 months. She has a history of occasional palpitations and dizziness. She lost her fiancé in a car accident in which she was a passenger. |
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Definition
Anxiety-induced amenorrhea Posttraumatic stress disorder Depression Hyperthyroidism * CBC TSH, FT4 Urine cortisol level Progesterone challenge test LH/FSH, estradiol levels |
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Term
VAGINAL BLEEDING Key History Pre- vs. postmenopausal status, duration, amount; menstrual history and relation to last menstrual period; associated discharge, pelvic or abdominal pain, or urinary symptoms; trauma; medications (especially blood thinners, contraceptives); history of easy bleeding or bruising; history of abnormal Pap smears. |
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Definition
Key Physical Exam Vital signs; abdominal exam; complete pelvic exam. |
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Term
17 yo F presents with prolonged, excessive menstrual bleeding occurring irregularly within the past 6 months. |
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Definition
Dysfunctional uterine bleeding Coagulation disorder (eg, von Willebrand’s disease, hemophilia) Cervical cancer Molar pregnancy Hypothyroidism Diabetes mellitus * Urine hCG Pelvic exam Cervical culture Pap smear CBC ESR Glucose PT/PTT LH/FSH, TSH, prolactin U/S—pelvis |
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Term
61 yo obese F presents with profuse vaginal bleeding for the past month. Her last menstrual period was 10 years ago. She has a history of hypertension and diabetes mellitus. She is nulliparous. |
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Definition
Endometrial cancer Cervical cancer Atrophic endometrium Endometrial hyperplasia Endometrial polyps Atrophic vaginitis * Pelvic exam Pap smear Endometrial biopsy Endometrial curettage U/S—pelvis Colposcopy Hysteroscopy |
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Term
45 yo G5P5 F presents with postcoital bleeding. She is a cigarette smoker and takes OCPs. |
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Definition
Cervical cancer Endometrial cancer Cervical polyp Cervicitis Trauma (eg, cervical laceration) * Pelvic exam Pap smear Colposcopy and biopsy HPV testing Endometrial biopsy |
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Term
28 yo F who is 8 weeks pregnant presents with lower abdominal pain and vaginal bleeding. |
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Definition
Spontaneous abortion Ectopic pregnancy Molar pregnancy * Urine hCG Quantitative serum hCG U/S—abdomen/pelvis Pelvic exam CBC PT/PTT |
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Term
32 yo F presents with sudden onset of left lower abdominal pain that radiates to the scapula and back and is associated with vaginal bleeding. Her last menstrual period was 5 weeks ago. She has a history of pelvic inflammatory disease and unprotected intercourse. |
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Definition
Ectopic pregnancy Ruptured ovarian cyst Ovarian torsion Pelvic inflammatory disease * Urine hCG Quantitative serum hCG U/S—abdomen/pelvis Pelvic exam Cervical cultures |
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Term
VAGINAL DISCHARGE Key History Amount, color, consistency, odor, duration; associated vaginal burning, pain, or pruritus; recent sexual activity; onset of last menstrual period; use of contraceptives, tampons, and douches; history of similar symptoms; history of STDs. |
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Definition
Key Physical Exam Vital signs; abdominal exam; complete pelvic exam. |
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Term
28 yo F presents with a thin, grayish-white, foulsmelling vaginal discharge. |
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Definition
Bacterial vaginosis Vaginitis—candidal Vaginitis—trichomonal Cervicitis (chlamydia, gonorrhea) * Pelvic exam Wet mount, KOH prep, “whiff test” pH of vaginal fluid Cervical cultures |
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Term
30 yo F presents with a thick, white, cottage cheese– like, odorless vaginal discharge and vaginal itching. |
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Definition
Vaginitis—candidal Bacterial vaginosis Vaginitis—trichomonal * Pelvic exam Wet mount, KOH prep, “whiff test” pH of vaginal fluid Cervical cultures |
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Term
35 yo F presents with a malodorous, profuse, frothy, greenish vaginal discharge with intense vaginal itching and discomfort. |
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Definition
Vaginitis—trichomonal Vaginitis—candidal Bacterial vaginosis Cervicitis (chlamydia, gonorrhea) * Pelvic exam Wet mount, KOH prep, “whiff test” pH of vaginal fluid Cervical cultures |
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Term
DYSPAREUNIA Key History Duration, timing; associated symptoms (vaginal discharge, rash, painful menses, GI symptoms, hot flashes); adequacy of lubrication, menopausal status, libido; sexual history, history of sexual trauma or domestic violence; history of endometriosis, pelvic inflammatory disease, or prior abdominal/pelvic surgeries. |
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Definition
Key Physical Exam Vital signs; abdominal exam; complete pelvic exam. |
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Term
54 yo F c/o painful intercourse. Her last menstrual period was 9 months ago. She has hot flashes. |
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Definition
Atrophic vaginitis Endometriosis Cervicitis Depression Domestic violence * Pelvic exam LH/FSH Wet mount, KOH prep Cervical cultures |
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Term
37 yo F presents with dyspareunia, inability to conceive, and dysmenorrhea. |
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Definition
Endometriosis Cervicitis Vaginismus Vulvodynia Pelvic inflammatory disease Depression Domestic violence * Pelvic exam Wet mount, KOH prep Cervical cultures U/S—pelvis Laparoscopy Endometrial biopsy |
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Term
ABUSE Key History Establish confidentiality; directly question about physical, sexual, or emotional abuse and about fear, safety, backup plan; history of frequent accidents/injuries, mental illness, drug use; firearms in the home. |
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Definition
Key Physical Exam Vital signs; complete exam ± pelvic exam. |
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Term
28 yo F c/o multiple facial and bodily injuries. She claims that she fell on the stairs. She was hospitalized for physical injuries 7 months ago. She presents with her husband. |
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Definition
Domestic violence Osteogenesis imperfecta Substance abuse Consensual violent sexual behavior * XR—skeletal survey CT—maxillofacial Urine toxicology CBC |
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Term
30 yo F presents with multiple facial and physical injuries. She states that she was attacked and raped by 2 men. |
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Definition
Rape Domestic violence *Forensic exam (sexual assault forensic evidence [SAFE] collection kit) Pelvic exam Urine hCG Wet mount, KOH prep Cervical cultures Chlamydia and gonorrhea testing XR—skeletal survey CBC HIV antibody Viral hepatitis serologies |
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Term
JOINT/LIMB PAIN Key History Location, quality, intensity, duration, pattern (small vs. large joints; number involved; swelling, redness, warmth); associated symptoms (constitutional, red eye, oral or genital ulceration, diarrhea, dysuria, rash, focal numbness/weakness, morning stiffness); exacerbating and alleviating factors; trauma (including vigorous exercise); medications; DVT risk factors; alcohol and drug use; family history of rheumatic disease. |
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Definition
Key Physical Exam Vital signs; HEENT and musculoskeletal exams; relevant neurovascular exam. |
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Term
30 yo F presents with wrist pain and a black eye after tripping, falling, and hitting her head on the edge of a table. She looks anxious and gives an inconsistent story. |
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Definition
Domestic violence Factitious disorder Substance abuse * XR—wrist CT—head Urine toxicology |
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Term
30 yo F secretary presents with wrist pain and a sensation of numbness and burning in her palm and the first, second, and third fingers of her right hand. The pain worsens at night and is relieved by loose shaking of the hand. There is sensory loss in the same fingers. Exam reveals a positive Tinel’s sign. |
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Definition
Carpal tunnel syndrome Median nerve compression in the forearm or arm Radiculopathy of nerve roots C6 and C7 in the cervical spine De Quervain’s tenosynovitis * Phalen’s maneuver and Tinel’s sign Finkelstein’s test Nerve conduction studies EMG |
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Term
28 yo F presents with pain in the interphalangeal joints of her hands accompanied by hair loss and a rash on her face. |
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Definition
Systemic lupus erythematosus (SLE) Rheumatoid arthritis Psoriatic arthritis Parvovirus B19 infection * ANA, anti-dsDNA, ESR, C3, C4, RF, CCP CBC XR—hands UA Antibody titers for parvovirus B19 |
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Term
28 yo F presents with pain in the metacarpophalangeal joints of both hands. Her left knee is also painful and red. She has morning joint stiffness that lasts for an hour. Her mother had rheumatoid arthritis. |
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Definition
Rheumatoid arthritis SLE Disseminated gonorrhea Arthritis associated with inflammatory bowel disease * XR—hands, left knee ANA, anti-dsDNA, ESR, RF, CCP CBC Cervical culture Arthrocentesis and synovial fluid analysis |
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Term
18 yo M presents with pain in the interphalangeal joints of both hands. He also has scaly, salmon-pink lesions on the extensor surface of his elbows and knees. |
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Definition
Psoriatic arthritis Rheumatoid arthritis SLE Gout * ANA, ESR, RF, CCP CBC XR—hands XR—pelvis/sacroiliac joints Uric acid |
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Term
65 yo F presents with inability to use her left leg or bear weight on it after tripping on a carpet. Onset of menopause was 20 years ago, and she did not receive HRT or calcium supplements. Her left leg is externally rotated, shortened, and adducted, and there is tenderness in her left groin. |
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Definition
Hip fracture Hip dislocation Pelvic fracture * XR—hip/pelvis CT or MRI—hip CBC, type and cross Serum calcium and vitamin D Bone density scan (DEXA) |
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Term
40 yo M presents with pain in the right groin after a motor vehicle accident. His right leg is flexed at the hip, adducted, and internally rotated. |
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Definition
Hip dislocation— traumatic Hip fracture * XR—hip CT or MRI—hip CBC, type and cross PT/PTT Urine toxicology and blood alcohol level |
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Term
56 yo obese F presents with right knee stiffness and pain that increases with movement. Her symptoms have gradually worsened over the past 10 years. She has noticed swelling and deformity of the joint and is having difficulty walking. |
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Definition
Osteoarthritis Pseudogout Gout Meniscal or ligament damage * XR—knee CBC ESR Knee arthrocentesis and synovial fluid analysis (cell count, Gram stain, culture, crystals) Uric acid MRI—knee |
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Term
45 yo M presents with fevers and right knee pain with swelling and redness. |
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Definition
Septic arthritis Gout Pseudogout Lyme arthritis Trauma Reiter’s syndrome (reactive arthritis) * CBC Knee arthrocentesis and synovial fluid analysis (cell count, Gram stain, culture, crystals) Blood, urethral cultures XR—knee Uric acid Lyme titers—IgG and IgM |
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Term
65 yo M presents with right foot pain. He has been training for a marathon. |
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Definition
Stress fracture Plantar fasciitis Foot sprain or strain * XR—foot Bone scan—foot MRI—foot |
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Term
65 yo M presents with pain in the heel of the right foot that is most notable with his first few steps and then improves as he continues walking. He has no known trauma. |
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Definition
Plantar fasciitis Heel fracture Splinter/foreign body * XR—heel Bone scan—foot |
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Term
55 yo M presents with pain in the elbow when he plays tennis. His grip is impaired as a result of the pain. There is tenderness over the lateral epicondyle as well as pain on resisted wrist dorsiflexion (Cozen’s test) with the elbow in extension. |
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Definition
Tennis elbow (lateral epicondylitis) Stress fracture * XR—arm Bone scan MRI—elbow |
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Term
27 yo F presents with painful wrists and elbows, a swollen and hot knee joint that is painful on flexion, a rash on her limbs, and vaginal discharge. She is sexually active with multiple partners and occasionally uses condoms. |
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Definition
Disseminated gonorrhea Rheumatoid arthritis SLE Reiter’s syndrome (reactive arthritis) * Knee arthrocentesis and synovial fluid analysis (cell count, Gram stain, culture) ANA, anti-dsDNA, ESR, RF, CCP CBC Blood, cervical cultures XR—knee |
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Term
60 yo F presents with pain in both legs that is induced by walking and is relieved by rest. She had cardiac bypass surgery 6 months ago and continues to smoke heavily. |
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Definition
Peripheral vascular disease (intermittent claudication) Leriche syndrome (aortoiliac occlusive disease) Lumbar spinal stenosis (pseudoclaudication) Osteoarthritis * Ankle-brachial index Doppler U/S—lower extremity Angiography MRI—L-spine |
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Term
45 yo F presents with right calf pain. Her calf is tender, warm, red, and swollen compared to the left side. She was started on OCPs 2 months ago for dysfunctional uterine bleeding. |
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Definition
DVT Baker’s cyst rupture Myositis Cellulitis Superficial venous thrombosis * Doppler U/S—right leg CBC D-dimer |
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Term
60 yo F c/o left arm pain that started while she was swimming and was relieved by rest. |
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Definition
Angina/MI Tendinitis Osteoarthritis * ECG CBC XR—shoulder CXR Echocardiography Stress test |
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Term
50 yo M presents with right shoulder pain after falling onto his outstretched hand while skiing. He noticed deformity of his shoulder and had to hold his right arm. |
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Definition
Shoulder dislocation Fracture of the humerus Rotator cuff injury * XR—shoulder XR—arm MRI—shoulder |
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Term
55 yo M presents with crampy bilateral thigh and calf pain, fatigue, and dark urine. He is on simvastatin and clofibrate for hyperlipidemia. |
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Definition
Rhabdomyolysis due to statins Polymyositis Inclusion body myositis * CBC Phosphate, potassium, BUN/Cr, glucose, calcium, uric acid CPK Aldolase UA Urine myoglobin |
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Term
LOW BACK PAIN Key History Location, quality, intensity, radiation, context (moving furniture, bending/twisting, trauma), timing (disturbs sleep); associated symptoms (especially constitutional, incontinence); exacerbating and alleviating factors; history of cancer, recurrent UTIs, diabetes, renal stones, IV drug use, smoking. |
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Definition
Key Physical Exam Vital signs; neurologic exam (especially L4–S1 nerve roots); back palpation and range of motion (although rarely of diagnostic utility); hip exam (can refer pain to the back); consider rectal exam. |
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Term
45 yo F presents with low back pain that radiates to the lateral aspect of her left foot. The straight leg raise is positive. The patient is unable to tiptoe. |
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Definition
Disk herniation Lumbar muscle strain Tumor in the vertebral canal * XR—L-spine MRI—L-spine |
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Term
45 yo F presents with low back pain that started after she cleaned her house. The pain does not radiate, and there is no sensory deficit or weakness in her legs. Paraspinal muscle tenderness and spasm are also noted. |
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Definition
Lumbar muscle strain Disk herniation Vertebral compression fracture * XR—L-spine MRI—L-spine |
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Term
45 yo M presents with pain in the lower back and legs during prolonged standing and walking. The pain is relieved by sitting and leaning forward (eg, pushing a grocery cart). |
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Definition
Lumbar spinal stenosis Lumbar muscle strain Tumor in the vertebral canal Peripheral vascular disease * MRI—L-spine (preferred) XR—L-spine CT—L-spine Ankle-brachial index |
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Term
17 yo M presents with low back pain that radiates to the left leg and began after he fell on his knee during gym class. He also describes areas of loss of sensation in his left foot. The pain and sensory loss do not match any known distribution. He insists on requesting a week off from school because of his injury. |
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Definition
Malingering Lumbar muscle strain Disk herniation Knee or leg fracture Ankylosing spondylitis * XR—L-spine/knee MRI—L-spine |
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Term
CHILD WITH FEVER No child will be present; the mother will relate the story. When you enter the examination room, you may see a telephone with instructions to pick up the handset. Upon doing so, you will be speaking to the parent of the child. Key History Severity, duration; associated localizing symptoms such as rash, wheezing, cough, and ear discharge; poor appetite, convulsions, lethargy, sleepiness; sick contacts, day care, immunizations. |
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Definition
Key Physical Exam Vital signs; HEENT, neck, heart, lung, abdominal, and skin exams. |
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Term
20-day-old M presents with fever, decreased breastfeeding, and lethargy. He was born at 36 weeks as a result of premature rupture of membranes. |
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Definition
Neonatal sepsis Meningitis Pneumonia Pyelonephritis * Physical exam CBC Electrolytes Blood culture LP—CSF analysis CXR UA, urine culture |
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Term
3 yo M presents with a 2-day history of fever and pulling on his right ear. He is otherwise healthy, and his immunizations are up to date. His older sister recently had a cold. The child attends a day care center. |
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Definition
Acute otitis media URI Meningitis Pyelonephritis * Physical exam (including pneumatic otoscopy) CBC Blood culture Tympanocentesis culture LP—CSF analysis UA, urine culture |
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Term
12-month-old M presents with fever for the past 2 days accompanied by a maculopapular rash on his face and body. He has not yet received the MMR vaccine. |
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Definition
Measles (or other viral exanthem) Rubella Roseola Fifth disease Varicella Scarlet fever Meningitis * Physical exam CBC Viral antibodies/titers Throat swab for culture LP—CSF analysis |
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Term
4 yo M presents with diarrhea, vomiting, lethargy, weakness, and fever. The child attends a day care center where several children have had similar symptoms. |
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Definition
Gastroenteritis (viral, bacterial, parasitic) Food poisoning UTI URI Volvulus Intussusception * Physical exam Stool exam and culture CBC Electrolytes UA, urine culture AXR |
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Term
CHILD WITH GI SYMPTOMS No child will be present; only the parent will relate the story, either in person or by telephone. Key History Onset, location, quality, intensity, duration, radiation, timing (relation to meals); associated symptoms (constitutional, GI, cardiac, pulmonary, renal, pelvic); changes in weight, skin rash, bloody/mucoid stools, change in stool color; exacerbating and alleviating factors; history of similar symptoms; history of abdominal surgeries; medications; sick contacts, day care, immunizations. |
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Definition
Key Physical Exam Vital signs; exam for signs of dehydration (BP, heart rate, skin turgor); heart and lung exams; abdominal exam; rectal exam; pelvic exam (women). |
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Term
1-month-old F is brought in because she has been spitting up her milk for the last 10 days. The vomiting episodes have increased in frequency and forcefulness. Emesis is nonbloody and nonbilious. The episodes usually occur immediately after breastfeeding. She has stopped gaining weight. |
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Definition
Pyloric stenosis Partial duodenal atresia GERD Gastroenteritis Hepatitis UTI Otitis media * Physical exam CBC Electrolytes U/S—abdomen Barium swallow pH probe Endoscopy AST/ALT/bilirubin/ alkaline phosphatase UA, urine culture Tympanocentesis culture |
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Term
3 yo M presents with constipation. The child has had 1 bowel movement per week since birth despite the use of stool softeners. At birth, he did not pass meconium for 48 hours. He has poor weight gain. There is a family history of this problem. |
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Definition
Hirschsprung’s disease Low-fiber diet Anal stenosis Hypothyroidism Lead poisoning * Physical exam Rectal exam Stool exam and culture Barium enema Suction rectal biopsy Anorectal manometry TSH, FT4 CBC Electrolytes Serum lead level |
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Term
8-month-old F presents with sudden-onset colicky abdominal pain with vomiting. The episodes are 20 minutes apart, and the child is completely well between episodes. She had loose stools several hours before the pain, but her stools are now bloody. |
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Definition
Intussusception Appendicitis Meckel’s diverticulum Volvulus Gastroenteritis Enterocolitis Blunt abdominal trauma * Physical exam Rectal exam, stool for occult blood CBC Electrolytes Contrast enema U/S—abdomen CT—abdomen |
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Term
7 yo M presents with abdominal pain that is generalized, crampy, worse in the morning, and seemingly less prominent during weekends and holidays. He has missed many school days because of the pain. Growth and development are normal. His parents recently divorced. |
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Definition
Somatoform disorder Malingering Irritable bowel syndrome Lactose intolerance Child abuse * Physical exam CBC Electrolytes U/S—abdomen CT—abdomen Amylase, lipase Stool exam |
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Term
2-month-old M presents with persistent crying for 2 weeks. The episodes subside after passing flatus or eructation. There is no change in appetite, weight, or growth. There is no vomiting, constipation, or fever. |
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Definition
Colic Formula allergy GERD Lactose intolerance Strangulated hernia Testicular torsion Gastroenteritis * Physical exam Rectal exam, stool for occult blood U/S—abdomen U/S—testicular |
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Term
CHILD WITH RED EYE No child will be present; only the parent will relate the story, either in person or by telephone. Key History Onset, location, duration, affecting one or both eyes; eye discharge, itching, pain, photophobia, tearing; associated symptoms (constitutional, dermatologic, GI, cardiac, pulmonary, renal, pelvic, rheumatologic); exacerbating and alleviating factors; medications; sick contacts, day care, immunizations; history of similar symptoms. |
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Definition
Key Physical Exam Vital signs; HEENT exam. |
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Term
3 yo F presents with a 3-day history of “pink eye.” It began in the right eye but now involves both eyes. She has mucoid discharge, itching, and difficulty opening her eyes in the morning. Her mother had the flu last week. She has a history of asthma and atopic dermatitis. |
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Definition
Bacterial conjunctivitis Viral conjunctivitis Keratitis Seasonal allergies Uveitis * Physical exam Ophthalmoscopic eye exam CBC Electrolytes Discharge cultures Slit lamp exam |
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Term
CHILD WITH SHORT STATURE No child will be present; only the parent will relate the story, either in person or by telephone. Key History Associated symptoms (constitutional, GI, cardiac, pulmonary, renal, pelvic, endocrine); medications; prenatal and birth history, growth history; past medical history; family history; cognitive abilities, school performance. |
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Definition
Key Physical Exam Vital signs; height, weight; HEENT, heart, lung, abdominal, and neurologic exams. |
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Term
14 yo M presents with short stature and lack of sexual development. His birth weight and length were normal, but he is the shortest child in his class. His father and uncles had the same problem when they were young, but they are now of normal stature. |
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Definition
Constitutional short stature Growth hormone (GH) deficiency Hypothyroidism Chronic renal insufficiency Genetic causes Cystic fibrosis * Physical exam CBC Electrolytes GH stimulation test IGF-1, IGFBP-3 levels TSH, FT4 XR—hand U/S—renal and cardiac Sweat chloride testing BUN/Cr Karyotype |
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Term
BEHAVIORAL PROBLEMS IN CHILDHOOD No child will be present; only the parent will relate the story, either in person or by telephone. Key History Onset, severity, duration, triggers; physical violence or use of weapons; substance use, developmental history, changes in environment or school performance; change in personality, anhedonia. |
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Definition
Key Physical Exam Vital signs; neurologic exam. |
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Term
9 yo M presents with a 2-year history of angry outbursts both in school and at home. His mother complains that he runs around “as if driven by a motor.” His teacher reports that he cannot sit still in class, regularly interrupts his classmates, and has trouble making friends. |
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Definition
Attention-deficit hyperactivity disorder (ADHD) Oppositional defiant disorder Manic episode Conduct disorder Hyperthyroidism * Physical exam Mental status exam TSH, FT4 EEG |
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Term
12 yo F presents with a 2-month history of fighting in school, truancy, and breaking curfew. Her parents recently divorced, and she just started school in a new district. Before her parents divorced, she was an average student with no behavioral problems. |
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Definition
Adjustment disorder Substance intoxication, abuse, or dependence Manic episode Oppositional defiant disorder Conduct disorder * Physical exam Mental status exam Urine toxicology |
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Term
15 yo M presents with a 1-year history of failing grades, school absenteeism, and legal problems, including shoplifting. His parents report that he spends most of his time alone in his room, adding that when he does go out, it is with a new set of friends. |
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Definition
Substance abuse Conduct disorder Oppositional defiant disorder Adjustment disorder * Urine toxicology Mental status exam Physical exam |
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Term
5 yo M presents with a 6-month history of temper tantrums that last 5–10 minutes and immediately follow a disappointment or a discipline. He has no trouble sleeping, has had no change in appetite, and does not display these behaviors when he is at day care. |
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Definition
Age-appropriate behavior ADHD Oppositional defiant disorder * Physical exam Mental status exam |
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