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Crousillac
Final Exam Chapter 12
47
Biology
Undergraduate 1
12/11/2010

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Term
What is the purpose of DNA?
Definition
DNA is the instructions that tells the cell what to do
Term
What are the results of DNA?
Definition
Proteins are the results of the instructions of DNA.
Term
What does the evidence of the study of metabolic defects show?
Definition
provided evidence that genes lead to proteins
Term
What is the cause of some metabolic disorders?
Definition
a blocked pathway
Term
What are inherited diseases the result of?
Definition
lack of an enzyme
Term
What can a blockage in a pathway do?
Definition
It can stop the production of something we need and also may lead to accumulation of something we don't want.
Term
is the synthesis of RNA using DNA as a template
Definition
transcription
Term
What is RNA complementary to?
Definition
DNA
Term
RNA that is synthesized from a gene coding for a protein is
Definition
messenger RNA (mRNA)
Term
What are the differences between DNA and RNA?
Definition

1.the sugar- deoxyribose(DNA) versus ribose(RNA)

2.the base- thymine(DNA) replaced by uracil(RNA)

 

Term
What are the types of bases for DNA?and what are the base pairs?
Definition

adenine(A),thymine(T), cytosine(C), guanine(G)

A-T

T-A

C-G

G-C

 

Term
What are the types of bases for RNA? what are the base pairs?
Definition

adenine(A),uracil(U), cytosine(C), guanine(G)

RNA-DNA

A-T

U-A

C-G

G-C

RNA-RNA

A-U

U-A

C-G

G-C

Term
is the synthesis of a polypeptide(protein) directed by mRNA
Definition
translation
Term
Why is the process of RNA to proteins referred to as translation?
Definition

converting the language of nucleic acids into the language of proteins:

  • 4 bases in nucleic acids
  • 20 amino acids in proteins
Term
Where does translation occur?what happens during it?
Definition
occurs in the ribosomes. proteins are synthesized according to the genetic message of sequential codons in the mRNA.
Term
is a three-nucleotide sequence in mRNA that specifies which amino acid will be added to a growing polypeptide or signals the termination of translation
Definition
codon
Term
What act as the interpreter between the nucleotide language of mRNA and the amino acid language of proteins?
Definition
transfer RNA(tRNA) and ribosomal RNA(rRNA)
Term
In the genetic code what specifies an amino acid?
Definition
a triplet of nucleotides
Term
How many nucleotides are in RNA?How many amino acids?
Definition
4 nucleotides, and 20 amino acids
Term
Why are only 20 amino acids formed from the 64 possible combinations of the bases?
Definition
An amino acid can be encoded by more than one nucleotide triplet.
Term
What are the steps of the Transciption process?
Definition

1.initiation

2.elongation

3.termination

Term
Describe the first step of the transcription process.
Definition
Initiation- RNA polymerase binds to the promoter region of the DNA near the beginning of a gene, seperating the double helix near the promoter.
Term
Describe the second step of the transcription process?
Definition
Elongation- RNA polymerase travels along the DNA template strand, catalyzing the addition of ribose nucleotides into an RNA molecule. The nucleotides in the RNA are complementary to the template strand of the DNA.
Term
Describe the third step of the transcription process.
Definition
Termination- At the end of a gene, RNA polymerase encounters a sequence of DNA called a termination signal. RNA polymerase detaches from the DNA and releases the RNA molecule.
Term
What is the order of steps in the transcription process?
Definition

1.initiation

2.elongation

3.termination

Term
How does initiation begin?
Definition
RNA polymerase finds a promoter region and binds, causing DNA double helix to unwind.
Term
If the mRNA transcript AUGCGUGCAAU were to leave the nucleus and undergo translation at a ribosome, what would be the sequence of anticodons translating this nucleotide into protein?
Definition
UACGCGACGUUA
Term
What is translation?
Definition
the RNA-directed synthesis of proteins
Term
What happens during the translation process?
Definition
proteins are synthesized according to the genetic message of sequential codons in the mRNA
Term

The sequence of nucleotides present in the DNA is reflected by the sequence in the mRNA.

And

The sequence of nucleotides in a mRNA determines the sequence of amino acids.

And

The sequence of amino acids determines the proteins.

Definition
Term
is where proteins are built
Definition
ribosome
Term
What do the ribosomes coordinate?
Definition
the pairing of tRNA anticodons with mRNA codons
Term
The subunits of a ribosomal RNA(rRNa) and protein combine only when?
Definition
combine as a ribosome only when they are translating a protien
Term
The ribosome holds all the components together as what happens?
Definition
as enzymes transfer the next amino acid to the growing polypeptide chain
Term
Where does protein synthesis occur?
Definition
on the ribosomes outside the nucleus
Term
What part of tRNA reads the mRNA?
Definition
the anticodon
Term
What is tRNA's other role as interpreter?
Definition
to transfer the correct amino acid from the cytoplasmic pool of amino acids to the ribosome for protein synthesis
Term
Through what method is the gene decoded to synthesize a protein?
Definition
one codon=>one anticodon=>one amino acid
Term
are permanent changes in the DNA that can involve large chromosomal regions or a single nucleotide pair
Definition
mutations
Term
are mutations limited to one or two nucleotides in a single gene, and can affect the function of a protein
Definition
point mutations
Term
the replacement of one base with another ex. nucleotide pair changed from A-T to T-A, cause mutations
Definition
substitutions
Term
is the insertion of one or more nucleotide pairs into a gene ex. new necleotide pair T-A inserted into new DNA strand
Definition
insertion mutation
Term
is the deletion of one or more nucleotide pairs from a gene ex. a C-G nucleotide pair is taken out of orignal DNA strand for new DNA strand
Definition
deletion mutation
Term
can cause a process called ionization in our DNA
Definition
radiation
Term
What does radiation do to DNA molecules?
Definition
Causes DNA molecules to lose or gain electrons, resulting in the breaking apart of our DNA, and rearrangement of bases(mutation)
Term
What are the parts of a ribosome?
Definition
a large subunit composed of P site(holds the tRNA with the polypeptide chain attatched) and A site(holds the tRNA with the next amino acid to be added) binding sites and a catalytic site and a small unit
Term
How many codons is an amino acid?
Definition
1 codon= 1 amino acid
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