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includes the bones, their cartilages, ligaments and tendons |
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the study of bone structure and treatment of bone disorders |
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Support • Protection • Assistance in movement • Mineral homeostasis • Blood cell production |
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macroscopic parts of long bone |
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the body or shaft of a long bone |
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the proximal and distal ends of a long bone |
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The regions between the epiphysis and diaphysis. |
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the growth zone of hyaline cartilage |
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the bony fusion of the growth zone |
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hyaline cartilage over the bone ends of freely movable joints. |
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Connective tissue that surrounds bone except for the articular cartilage. |
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Periosteum:Composed of two parts |
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a. outer fibrous layer b. inner osteogenic layer |
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dense irregular connective tissue |
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hollow cylindrical space within the diaphysis |
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thin membrane that lines the bone surface of the medullary cavity. |
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composed of 25 % water, 25% collagen fibers and 50% crystallized mineral salts. |
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The mineral salts crystallizing in a framework of collagen fibers causing the extracellular matrix to harden. |
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Four cell types in bone tissue |
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1. Osteogenic cells: unspecialized stem cells derived from mesenchyme. 2. Osteoblasts: Synthesize and secret collagen fibers and initiate calcification 3. Osteocytes: mature bone cells function to maintain its daily metabolism 4. Osteoclasts: It functions in digesting the extracellular matrix and then reabsorbing the digested product & releasing it to the blood. |
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unspecialized stem cells derived from mesenchyme. |
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Synthesize and secret collagen fibers and initiate calcification |
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mature bone cells function to maintain its daily metabolism |
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It functions in digesting the extracellular matrix and then reabsorbing the digested product & releasing it to the blood. |
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found beneath the periosteum of all bones and makes up the diaphysis of long bones. |
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Perforating or V olkmann’ s canals |
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transverse canals penetrated by blood vessels, lymph vessels and nerves. |
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Central/Halversian canals |
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canals that run longitudinally through the bone. |
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rings of calcified extracellular matrix |
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‘little lakes’, the small spaces between the lamellae |
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tiny channels filled with interstitial fluid that radiate in all directions from the lacunae. |
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repeating structural units which consist of a central canal with concentric lamellae arranged |
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The areas between the osteons that are fragments of older osteons |
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encircle the bone beneath the periosteum or encircle the medullary cavity. |
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lamellae arranged in an irregular lattice of thin columns called trabeculae. |
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Periosteal arteries & veins Nutrient artery & vein |
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Metaphyseal artery & veins Epiphyseal artery & vein |
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Embryonic skeleton: Involves replacement of preexisting connective tissue with bone, does not lead to any structural differences in bone. |
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I. INTRAMEMBRANOUS OSSIFICATION |
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A. Development of ossification center B. Calcification C. Development of trabeculae D. Development of the periosteum |
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II. ENDOCHRONDRAL OSSIFICATION |
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A. Development of the cartilage model B. Growth of the cartilage model C. Development of the primary ossification center D. Development of the medullary cavity E. Develoment of the secondary ossification center F. Formation of the articular cartilage & epiphyseal plate |
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lengthwise growth of bone at the epiphyseal plate |
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The ongoing replacement of old bone tissue by new bone throughout life |
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the breakdown of minerals and collagen fibers by osteoclasts |
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the addition of minerals and collagen by osteoblasts |
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• estrogens close the epiphyseal growth places • Vitamin A stimulates activity of osteoblasts • Vitamin C is needed for synthesis of collagen • Vitamin D helps build bone by increasing the absorption of calcium from foods • Vitamins K and B12 are also needed for synthesis of bone proteins • Insulin like growth factors, liver & bone, hGH, T3, T4 |
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1. Formation of fracture hematoma 2. Fibrocartilaginous callus formation 3. Bony callus formation 4. Bone remodeling |
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The broken ends of the bone protrude through the skin |
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The bone is splintered, crushed, or broken into pieces |
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A partial fracture in which one side of the bone is broken and the other side bends |
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One end of the fractured bone is forcefully driven into another |
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Fracture of the fibula, with injury of the tibial articulation |
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A fracture of the radius in which the distal fragment is displaced |
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A series of microscopic fissures in bone |
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