Term
| What is the minimum number for a properly constituted IACUC? (Guide regs?) |
|
Definition
|
|
Term
| What are the minimum positions that must be filled for a properly constituted IACUC? |
|
Definition
| Chair, Vet (VMO), Non-Affilliated, Non-Scientist, Scientist |
|
|
Term
| What body is responsible for administration of PHS Policy? |
|
Definition
|
|
Term
| PHS Policy covers animals being used under what circumstances? |
|
Definition
| Biomedical or behavioral research supported by PHS |
|
|
Term
| List the nine points covered in the US Government principles? |
|
Definition
| Transportation according to AWA, must be relevant to human or animal health, appropriate species and minimum number, minimize pain and distress, use of analgesia for painful procedures, euthanasia to end suffering, lving conditions appropriate, personnel must be trained, exceptions must be approved by an IACUC. |
|
|
Term
| What bodies require the use of the Guide in implementing an animal care program? |
|
Definition
| PHS Policy, VA Handbook, DoD Regs |
|
|
Term
| What animals does the Guide apply to? |
|
Definition
| Any live vertebrate animals produced or used in research, testing, or teaching |
|
|
Term
|
Definition
| The proper care, use, and humane treatment of laboratory animals produced for or used in research, testing, or teaching |
|
|
Term
| What are the 3 R's? (Russell and Burch) |
|
Definition
| Replace (use non-animal or lower animal methods), refine (techniques to enhance well-being and minimize P&D), reduce (reduce numbers) |
|
|
Term
| When something is covered by two differing sets of regs, which should apply? |
|
Definition
|
|
Term
| Define engineering standard? |
|
Definition
| Specifies in detail a method, technology or technique for a desired outcome |
|
|
Term
| Define performance standard? |
|
Definition
| Describes a desired outcome but grants flexibility, and allows modification based on measured outcomes |
|
|
Term
| Define practice standard? |
|
Definition
| Application of professional judgment by qualified, experienced people to a task or process to benefit animal care and use |
|
|
Term
|
Definition
| Practical statements of collective wisdom, convention, or management direction that are internal to the institution |
|
|
Term
|
Definition
| Broader than Policies. Accepted generalizations frequently endorsed by varied organizations |
|
|
Term
|
Definition
| Standard Operating Procedures-define detailed step-by-step processes meant to ensure the consistent application of institutional practices |
|
|
Term
| Who is responsible for overseeing and evaluating the training program for all animal users? |
|
Definition
|
|
Term
| What information should a database search strategy include? |
|
Definition
| Name of database, dates covered, date search was performed, search strategy |
|
|
Term
| Define the requirements of the IO? |
|
Definition
| must be the Chief Executive Officer and have authority to commit institutional resources in support of the animal care and use program. |
|
|
Term
|
Definition
| More than 50% of voting members |
|
|
Term
| How many members are required to conduct a semi-annual evaluation according to USDA AWAR? |
|
Definition
|
|
Term
| Who has the authority to decide if a deficiency discovered in the semi-annual review is significant or minor? |
|
Definition
| The IACUC and the IO together |
|
|
Term
| What information must be provided in the report for deficiencies identified during the IACUC semi-annual self-evaluation? |
|
Definition
| A reasonable and specific plan and schedule for correcting significant and minor deficiencies |
|
|
Term
| What criteria dictate that an institution must follow PHS policy? |
|
Definition
|
|
Term
| What is the primary mission of the Animal Welfare Information Center? |
|
Definition
| Provides assistance with alternatives and database searches |
|
|
Term
| Which agency requires an annual report of the number of animals used by pain/distress category? |
|
Definition
| United States Department of Agriculture |
|
|
Term
| The idea that Procedures that are painful to humans should be assumed to cause pain in animals unless there is evidence to the contrary comes from where? |
|
Definition
| US Government Principles on the use of Animals in research |
|
|
Term
| Primary oversight of animal research rests with what 3 entities? |
|
Definition
| The IACUC, the IO, and the AV |
|
|
Term
| Who holds the ultimate responsibility for maintaining compliance in the animal care program |
|
Definition
|
|
Term
| USDA Regulations (AWAR) require the IACUC to include? |
|
Definition
| Three members: A chair, AV, and non-affiliated member |
|
|
Term
| How long can a PHS assurance be good for? |
|
Definition
| No longer than 5 years-depends on institution |
|
|
Term
| USDA registration must be updated every ? Years? |
|
Definition
|
|
Term
| PHS and AWAR require records to be kept for how long after a protocol terminates? |
|
Definition
|
|
Term
| What two circumstances would require you to submit your semi-annual report to OLAW? |
|
Definition
| If OLAW requests, or if your institution is not accredited by AAALAC |
|
|
Term
| What 3 circumstances must be reported to PHS (if PHS funding applies)? |
|
Definition
| Suspension of animal activity by the IACUC, serious deviation from the Guide unless previously approved by the IACUC, serious continuing non-compliance with PHS policy. |
|
|
Term
| Who is responsible for overseeing and evaluating the effectiveness of the animal training program? |
|
Definition
|
|
Term
| What law established guidelines for the proper care and treatment of animals used in behavioral and biomedical research, and for the organization and operation of the IACUC? |
|
Definition
| Health Research Extension Act of 1985. Public Law 99-158 |
|
|
Term
| Who is required to adhere to the guidelines under the health research extension act of 1985? |
|
Definition
| Any entity that conducts biomedical or behavioral research with funds provided under the act (including the NIH and National Research Institute). |
|
|
Term
| Who must appoint the animal care committee? |
|
Definition
|
|
Term
| What are PHS requirements for the establishment of an IACUC? |
|
Definition
| At least 3 members; at least one non-affiliated and at least one vet |
|
|
Term
| What are the duties of an IACUC under HRE Act of 1985? |
|
Definition
| 1. Review research animal care and treatment and the facilities at least semi-annually to evaluate compliance with guidelines. 2. Keep appropriate records, and 3. File an annual certification of review and findings with PHS. |
|
|
Term
| Can PHS policy apply outside the US? |
|
Definition
| Yes if the institution uses PHS funds |
|
|
Term
| Define "Animal" according to PHS policy |
|
Definition
| Any live, vertebrate animal used or intended for use in research, research training, experimentation, or biological testing or for related purposes |
|
|
Term
| Who administers the Animal Welfare Act, Public Law 89-544, 1966 |
|
Definition
|
|
Term
| Name the agensies included in the Public Health Service |
|
Definition
| Agency for Healthcare Research and Quality, Centers for Disease Control and Prevention, the Food and Drug Adniminstration, the Health Resources and Services Administration, the Indian Health Service, the National Institutes of Health, and the Substance Abuse and Mental health SErvices Administration |
|
|
Term
| What government agency contains the Office of Laboratory Animal Welfare? |
|
Definition
| Office of the Director, National Institutes of Health |
|
|
Term
| What is the maximum length of time an Assurance can be approved for? |
|
Definition
|
|
Term
| What does the PHS require institutions to use as a basis for implementing their animal care programs? |
|
Definition
|
|
Term
| What is the accrediting body recognized by PHS? |
|
Definition
| Association for the Assessment and Accreditation of Laboratory Animal Care, International |
|
|
Term
| What are the PHS defined duties of the IACUC? (Also nearly identical to USDA AWAR) |
|
Definition
| 1. Review the Animal Care Program at least once every 6 months, 2. Inspect Animal Facility at least once every 6 months, 3. Prepare proper semi-annual reports to the IO at least once every 6 months, 4. Review concerns regarding animal use, 5. Make recommendations to the IO, 6 & 7. Review and approve or require mod or withhold approval of animal activities or significant modifications of activities supported by PHS, 8. Be authorized to suspend activities in accordance with PHS policy. |
|
|
Term
| Semi-annual report to IO should include what according to PHS policy? |
|
Definition
| Descriptions of the nature and extent of the institution's adherence to the Guide and Policy. Must specifically identify any departures, and must state reasons for departures. Must distinguish significant from minor deficiencies, and must give a reasonable and specific plan for for correcting deficiencies. |
|
|
Term
| Define a significant deficiency according to PHS Policy? |
|
Definition
| One which, in the judgement of the IACUC and IO is or may be a threat to the health or safety of the animals. |
|
|
Term
| What is required before the IACUC can suspend an activity? |
|
Definition
| Vote to suspend by a majority of the IACUC at a convened meeting of a quorum based on deviations from the AWA, the Guide, or PHS Policy, or the Assurance Statement. |
|
|
Term
| What body administers PHS Policy? |
|
Definition
|
|
Term
| What circumstances require a prompt report to OLAW? |
|
Definition
| 1. Any serious or continuing noncompliance with PHS Policy, 2. Any serious deviation from the Guide, or 3. Any suspension of an activity by the IACUC. |
|
|
Term
| What two things are required before PHS will make an award for activities involving animals? |
|
Definition
| The institution must have an approved Assurance on file, and verification of approval of the activity by the IACUC. |
|
|
Term
| When was the AWA first passed? |
|
Definition
|
|
Term
| What agency is responsible for enforcing the AWA? |
|
Definition
|
|
Term
| PHS Policy requires an animal care program to consist of what 7 things? |
|
Definition
| 1. A properly constituted IACUC. 2. Procedures for self-monitoring. 3. Veterinary care. 4. Occ Health program. 5. Personnel training. 6. An environment, housing and management program for animals, and 7. Appropriately maintained hosuing facilities. |
|
|
Term
| How can a protocol be suspended by the IACUC? |
|
Definition
| At a meeting of a quorum with a majority vote. |
|
|
Term
| Does an abstention alter quorum or change the number of required votes for a majority? |
|
Definition
|
|
Term
| Can the veterinarian serve as IACUC Chair? |
|
Definition
| Yes, but OLAW considers it unadvisable in order to preserve the intended checks and balances of self regulation. |
|
|
Term
| If there is a question of compliance in a situation where two institutions are collaborating, which is the responsible? |
|
Definition
| PHS will "follow the money." AWARs hold the housing institution, and the institution that owns the animals responsible-although may not be the same |
|
|
Term
| What 2 laws form the basis of all functions and activities of IACUCs? |
|
Definition
| The Animal Welfare Act and amendments, and the Health Research Extension Act. |
|
|
Term
| What can PHS/OLAW do to an institution if they fail to comply with PHS policy, and fail to correct the deficiencies? |
|
Definition
| Ultimately, PHS/OLAW can withdraw approval of the Assurance, thereby making the institution ineligible for receiving PHS funds |
|
|
Term
| What can the USDA do to an institution if they fail to comply with the AWA and AWAR, and fail to correct the deficiencies? |
|
Definition
| Ultimately, the USDA can impose fines of up to $2,500 per count, and prison sentences of up to 1 year. The IO is held responsible on behalf of the institution. |
|
|
Term
| Freedom of Information Act applies to what kinds of records? |
|
Definition
| Federal government records that cannot be exempted or excluded. |
|
|
Term
|
Definition
| State laws that may permit public access to information reviewed and generated by the IACUC |
|
|
Term
| AWAR require semiannual inspections to include how many IACUC members? VA 1200.07? |
|
Definition
| 2 for USDA AWAR, 3 for VA |
|
|
Term
| Can institutions us an AAALAC inspection in lieu of a semiannual inspection? |
|
Definition
| Yes, if the report meets requirements in PHS policy and is endorsed by the IACUC |
|
|
Term
| How many IACUC members must sign the semiannual report? |
|
Definition
|
|
Term
| According to USDA AWAR, how many members can come from the same administrative unit? |
|
Definition
|
|
Term
| USDA AWAR require a minimum IACUC constitution of what? |
|
Definition
| Three members: Non-affiliated and VMO plus one other. |
|
|
Term
| Annual report to PHS must include? |
|
Definition
| Description of any program changes, certification of semi-annual review, any minority views that were filed. |
|
|
Term
| PHS Policy requires the IACUC to include? |
|
Definition
| Five members: vet, non-affiliated, scientist, non-scientist, Chair |
|
|
Term
| If the plan to correct deficiencies found in the semiannual inspection cannot be met, who must be informed and in what time frame? |
|
Definition
| APHIS, within 15 days of the lapsed deadline. VACO for VA, funding agency if federally funded. |
|
|
Term
| What is the definition of major surgery according to AWAR? |
|
Definition
| a surgical procedure that penetrates and exposes a body cavity, or produces a permanent impairment of physical or physiological functions. |
|
|
Term
| USDA-APHIS requires the PI to tell the IACUC what information about a database search? |
|
Definition
| The name of the database, the date the search was performed, and the search strategy (terms). |
|
|
Term
| The two new "musts" in the Guide regarding Disaster Planning included what? |
|
Definition
| That the plans must cover satelite facilities and provisions on euthanasia |
|
|
Term
| If the institution is PHS assured but not AAALAC Accredited, what must be included in the annual report to OLAW? |
|
Definition
| The IACUC Semiannual report |
|
|
Term
| When there is a change in name of institution, or ownership or operation for the research facility, how many days do you have to notify the APHIS AC Regional Director? |
|
Definition
|
|
Term
| According to USDA, APHIS and other relevent federal agencies must be notified within ? Days of a failure to correct a significant deficiency according to the schedule dictated by the IACUC. |
|
Definition
|
|
Term
| The Executive Agent for the DoD Directive number 3216.1 is the? |
|
Definition
|
|
Term
| OLAW recommends what reporting lines regarding the AV within an ACP? |
|
Definition
| The AV reports directly to the IO |
|
|
Term
| VA Policy requires a minimum IACUC constitution of what? |
|
Definition
| Five members: vet, non-affiliated, scientist, non-scientist, Chair |
|
|
Term
| Accorinding to USDA AWAR and PHS Policy, IACUC semiannual inspections must include? |
|
Definition
| All areas housing animals for more than 12 hours, and laboratories where animal procedures are performed with the exception of laboratories performing only non-survival surgical procedures. |
|
|
Term
| PHS policy places responsibility for assuring that all personnel conducting work on animals are properly trained with who? |
|
Definition
|
|
Term
| Who should receive training in animal care and use? |
|
Definition
| All staff who work directly with or in the vicinity of research animals, even temporarily |
|
|
Term
| What are some examples of "significant" modifications? |
|
Definition
| Changes to the objectives of a study, from non-survival to survival surgery, resulting in greater discomfort or invasiveness, in the species or number of animals used, in the PI, in anesthetic agents or use or withholding of analgesics, method of euthanasia, or duration, frequency, or number of procedures performed on an animal. |
|
|
Term
| Which entity does not require the IACUC to have a scientific member? |
|
Definition
|
|
Term
| Cervical dislocation should not be performed in rabbits weighing more than? |
|
Definition
|
|
Term
| Euthanasia agents that act by hypoxia are not recommended for which group of animals? |
|
Definition
|
|
Term
| What agency/law mandates occupational health service for employees who work with animals? |
|
Definition
|
|
Term
| According to OLAW, an IACUC can administratively approve an increase in non-USDA-regulated animals of up to what %? |
|
Definition
| Up to 10% of non-USDA regulated species |
|
|
Term
| Can the IACUC administratively approve a 5% increase in the number of a large USDA regulated species? |
|
Definition
| No. Must be reviewed by DMR, or FCR. |
|
|
Term
| PHS policy considers a space animal facility space if it houses animals more than ? Hours? |
|
Definition
|
|
Term
| PHS Policy requires facilities to use what as a basis for the development of their animal care and use policy? |
|
Definition
|
|
Term
| PHS Policy defines "Animal" as? |
|
Definition
| Any live vertebrate animals produced or used in research, testing, or teaching |
|
|
Term
| What type of drug must be used together with a neuromuscular blocking agent? |
|
Definition
|
|
Term
| What is the shelf life for feed that is fortified with non-stabilized Vitamin C? |
|
Definition
|
|
Term
|
Definition
| An aversive state in which an animal fails to cope or adjust to various stressors with which it is presented |
|
|
Term
| Which is lost first under the effects of anesthetics? Consciousness? Or Pain perception? |
|
Definition
|
|
Term
| If used in an animal room, how big must a floor drain be? |
|
Definition
|
|
Term
| Registration with the USDA must be updated every ? Years? |
|
Definition
|
|
Term
| PHS Letter of assurance must include what 3 components? |
|
Definition
| 1. Description of animal care and use program, 2. Institutional Status, 3. Composition of the IACUC |
|
|
Term
| A research facility must notify the AC Regional Director of the USDA by certified mail of any changes in operations affecting its status within ? Days? |
|
Definition
| within 10 days of the change. |
|
|
Term
| The IACUC must be appointed by the CEO? Or the IO? |
|
Definition
| The CEO, who may also be the IO |
|
|
Term
| AWAR require what to be used as the basis for the semiannual review? |
|
Definition
| AWAR title 9, Chapter I, subchapter A |
|
|
Term
| The annual review requirement comes from what law, administered by what body? |
|
Definition
|
|
Term
| The Office of Laboratory Animal Welfare is a part of what organization? |
|
Definition
| Public Health Service, National Institutes of Heath, Office of Extramural Research |
|
|
Term
| PHS policy requires what to be in place for an investigator to order custom antibodies or custom surgically altered animals? |
|
Definition
| The company must either have its own PHS Assurance or be covered by the awardee's Assurance, and must have project-specific IACUC approval for their production. |
|
|
Term
| Does PHS policy apply to the use of animal tissues obtained from dead animals? |
|
Definition
| No, unless the animal is killed for the study, or manipulated in a project-specific manner prior to euthanasia |
|
|
Term
| Does PHS policy apply to live embryonated eggs? |
|
Definition
| No, but it applies to the egg-laying adult, and the Assurance must address the care or euthanasia of unexpected hatchlings |
|
|
Term
| Does PHS Policy apply to larval forms of fish and amphibians? |
|
Definition
|
|
Term
| Does PHS Policy require IACUC approval for field studies that are observational only and do not interfere with live animals? |
|
Definition
|
|
Term
| Is the presence of any particular IACUC member required at every meeting to do business? |
|
Definition
| No, but the committee must be properly constituted. |
|
|
Term
| Does the IACUC have authority over activities not supported by PHS and not involving USDA covered species? |
|
Definition
| Yes, if the institution gives that authority to the IACUC or if it is described in the Assurance. |
|
|
Term
| What is the difference between a "significant change" to a PHS supported animal activity and a "change in scope" of a PHS supported animal activity? |
|
Definition
| A significant change must be reviewed and approved by the IACUC, but does not necessarily require notification of the NIH funding component. A Change in scope is a change in direction or type of research and would require notificaiton of PHS by the PI |
|
|
Term
| Should the IACUC report sanctions other than suspensions that are imposed by the IACUC or IO? |
|
Definition
| Sanctions imposed by the IACUC or IO due to serious or continuing noncompliance or serious deviations from the Guide must be reported to OLAW. |
|
|
Term
| Are all documents submitted to OLAW subject to FOIA? |
|
Definition
|
|
Term
| What are PHS requirements for recording and reporting minority views? |
|
Definition
| Institutions must maintain records of minority views expressed 1) as recommendations to the IO and/or 2) during semiannual inspections. |
|
|
Term
| Is a dissenting vote or abstention a minority opinion? |
|
Definition
| No. A minority opinion must be submitted by an IACUC member in writing. Can be submitted to OLAW, the IACUC, or the IO. The IACUC is required to include this in their annual report to OLAW. |
|
|
Term
| How should a deviation from a "must" statement in the Guide be handled? |
|
Definition
| IACUC approved constitutes an approved departure and must be reported in the semiannual report. Lack of IACUC approval constitutes serious noncompliance and must be immediately reported through the IO to OLAW. |
|
|
Term
| How should a deviation from a "should" statement in the Guide be handled? |
|
Definition
| Well-established performance standards are not departures and need not be reported. Deviation with IACUC approval is a departure and should be reported to the IO in the semiannual. Deviation without IACUC approval is noncompliance that must be reported to OLAW through the IO. |
|
|
Term
| PHS Policy requires protocols to be re-reviewed how often? |
|
Definition
|
|
Term
| PHS Policy requires DMR by at least how many IACUC members? |
|
Definition
|
|
Term
| USDA AWAR require continuing review of protcols no less than how often? |
|
Definition
|
|
Term
| USDA requires that records kept on each live dog or cat must include? |
|
Definition
| Name, address, USDA license #, State, driver's license number of person it was acquired from, date of acquisition, and description, species, sex, color, markings, tattoo, and ID mark on each dog or cat, and if adopted, name and address of person adpting, date of disposition, and method of transport. |
|
|
Term
| When are annual reports to USDA due? |
|
Definition
| Dec 1 of each calendar year |
|
|
Term
| USDA regs require an official tag on a dog or cat to include what information? |
|
Definition
| The letters USDA, number identifying the state and research facility, and number identifying the animal. |
|
|
Term
| PHS requires review of SOPs at what interval? |
|
Definition
|
|
Term
| VA requires review of SOPs how often? |
|
Definition
|
|
Term
| Is IACUC approval required for the use of animals in breeding programs, sentinals, blood donors, etc? |
|
Definition
| Yes, because these activities support the research program which supports research activities. |
|
|
Term
| Does PHS policy allow more than one PI? |
|
Definition
|
|
Term
|
Definition
| An unpleasant sensory or emotional experience associated with actual or potential tissue damage. |
|
|
Term
| What information is included in the annual report to OLAW? |
|
Definition
| Any changes in the animal care program, IACUC membership, AAALAC Accreditation status, and any minority reports. |
|
|
Term
| What information is included in the annual report to APHIS/USDA? |
|
Definition
| Number of each covered species according to pain category, assurances that animals were used according to accepted standards, and that alternatives to painful procedures were considered. Also include a description of any IACUC approved departure from USDA standards. |
|
|
Term
| Which agency requires a report within 15 working days if the institution fails to adhere to the plan to correct deficiencies after a semiannual inspection? |
|
Definition
|
|
Term
| PHS requires semiannual inspections to include what areas? |
|
Definition
| Animal facility, any satelite facility housing animals for more than 24h, and any area where any form of surgery is performed including non-survival. |
|
|
Term
| USDA requires semiannual inspections to include what areas? |
|
Definition
| All "animal study areas" that house animals for more than 12h. |
|
|
Term
| Are IACUCs required to do semiannual inspections of field study sites? |
|
Definition
| No, but the IACUC should be informed of the circumstances and ensure that all local and federal wildlife laws are followed. |
|
|
Term
| Under what circumstances may an investigator use a non-pharmaceutical grade compound in an animal? |
|
Definition
| When it is scientifically necessary, appropriately justified, and approved by the IACUC |
|
|
Term
| What are the "orange book" and the "green book"? |
|
Definition
| A listing of FDA-approved human drugs, and FDA-approved veterinary drugs, respectively |
|
|
Term
| List all duties of an IACUC to comply with AWAR, Guide, and PHS Policy? |
|
Definition
| Semiannual review of both program and facilities, report semiannually to the IO with all necessary components of the report, investigate and respond appropriately to concerns involving animal welfare, make recommendations to the IO regarding the ACP, review and approve, require C&M, or withhold approval from all protocols and significant modifications, and be authorized to suspend an activity if it doesn't comply with AWAR, the Guide, PHS Policy, or the Assurance statement. |
|
|
Term
| Is IACUC oversight of a secondary school science fair project necessary? |
|
Definition
| No. The AWAR specifically exclude elementary and secondary schools from the definition of research facility. |
|
|
Term
| Should the use of a live college mascot be reviewed by an IACUC? |
|
Definition
| Colleges with mascots are technically exhibitors, and do not require an IACUC, but technically should be licensed as an exhibitor. Need for IACUC approval depends on the institution's policies, and Assurance. At least housing and care should be adequate, and inspected by APHIS. |
|
|
Term
| Is IACUC review required for PHS covered field studies? |
|
Definition
| Field studies are exempted provided the study "does not harm or materially alter the animals' behavior. This excludes studies that involve any sort of trapping, harming, or handling of the animals, and such studies would require IACUC review. |
|
|
Term
| Does the DOD allow the use of dogs, cats, or NHP in trauma wound training or biological, chemical, or nuclear weopons development? |
|
Definition
| No. Other species must be used. |
|
|
Term
| What are the requirements for a properly constituted IACUC for DoD research? |
|
Definition
| Five members including vet, non-affiliated, and non-scientist. |
|
|
Term
| Define "animal" according to DoD policy |
|
Definition
| Any live vertebrate animal used in DoD research, training, experimentation or testing. Includes birds rats and mice, but excludes ceremonial animals. Includes animals killed for the purpose of research or training |
|
|
Term
| Both the USDA AWAR and PHS Policy require that PIs be notified of IACUC decisions in writing? |
|
Definition
|
|
Term
| The IO can reinstate an activity that was suspended by the IACUC? |
|
Definition
|
|
Term
| The IO can suspend an activity that was approved by the IACUC |
|
Definition
|
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Term
| If a facility that receives DoD funds is under USDA investigation, they must notify DoD and have a site visit within 30 days |
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Definition
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Term
| According to PHS Policy, the CEO and IO do not have to be the same person |
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Definition
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Term
| A change in anesthetic is a major change? |
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Definition
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Term
| The Ag Guide does not require the veterinarian to have training in laboratory animal science? |
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Definition
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Term
| The Joint Technical Working Group (JTWG) acts as a central advisory committee to the Armed Services Biomedical Research Evaluation and Management (ASBREM) Committee? |
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Definition
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Term
| If work on a protocol continues for one day after its annual or triennial approval has expired, this is noncompliance and must be reported? |
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Definition
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Term
| The IACUC can require more frequent reviews if it deems necessary? |
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Definition
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Term
| Barbituates are extremely painful when administered outside a vein? |
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Definition
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Term
| Immersing aquatic species in a bath saturated with CO2 is an acceptable method of euthanasia? |
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Definition
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Term
| USDA Regs require a Chair as one member? |
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Definition
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Term
| What must the constitution of the IACUC be according to the Guide? |
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Definition
| Vet, scientist, nonscientist, public member |
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Term
| What must the constitution of the IACUC be according to the VHA Handbook? |
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Definition
| Combined PHS and AWAR: 5 members: Chair, vet, scientist, nonscientist, nonaffiliated |
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Term
| What must the constitution of the IACUC be according to PHS Policy? |
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Definition
| Five members: vet, non-affiliated, scientist, non-scientist |
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Term
| What must the constitution of the IACUC be according to AWAR? |
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Definition
| Three members: Chair, vet, nonaffiliated |
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Term
| The Guide requires program review and facility inspection how often? |
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Definition
| Annually, but requires adherence to AWAR, which requires semiannually |
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Term
| According to the Guide, are multiple major survival surgeries allowed on a single animal for more than protocol? |
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Definition
| The process isn't banned, but is strongly discouraged and must be very critically reviewed by the IACUC. If USDA species are involved the IO must submit a request for approval to APHIS. |
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Term
| What regulatory bodies require a triennial review? |
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Definition
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Term
| DOD prohibits use of dogs, cats, NHP, or marine mammals for what types of research? |
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Definition
| Development of chem, bio, or nuc weapons, and infliction of any wound with any weapon for trauma training. |
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Term
| What does the DOD use as a source of standards for animal care? |
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Definition
| The Guide and AWAR, as well as all other relevant US or local laws |
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Term
| DOD guidelines cover animals under what circumstances? |
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Definition
| Live vertebrate animals used in DOD research, testing, or training. |
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Term
| What kinds of animals are excluded from DOD guidelines? |
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Definition
| Ceremonial, recreational, or military working animals, or farm animals |
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Term
| DOD protocols specifically require a statistical review by a qualified person? |
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Definition
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Term
| Must the veterinarian on the IACUC be the AV? |
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Definition
| No. The vet on the IACUC must have direct or delegated authority and responsibility for the animal program, but may be designated by the institutions's AV. |
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Term
| Who is responsible for ensuring that personnel are appropriately trained in procedures involving pain & distress, surgery, etc? |
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Definition
| The IACUC, but the VMO should provide guidance on this. |
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Term
| Can the nonaffiliated member be a scientist, vet, or biostatistician? |
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Definition
| Yes, as long as he/she does not use laboratory animals. |
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Term
| Can the nonaffiliated member be compensated for membership on the IACUC? |
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Definition
| Yes, as long as the compensation is not so significant as to constitute an important source of income. Compensation should be limited to time and travel expenses. |
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Term
| Appointment of a nonscientist to the IACUC is required by what regulations? |
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Definition
| PHS Policy, the Guide, VA Handbook, DoD Regs (not AWAR) |
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Term
| What is the Improved Standards for Laboratory Animals Act? |
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Definition
| Passed in 1985, amendment to the AWA that mandated IACUC protocol review and other standards we use today. |
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Term
| What is the Health Research Extension Act? |
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Definition
| Passed in 1985, mandates the PHS to implement standards of laboratory animal care in PHS Policy. |
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Term
| Name some of the required components for protocol review |
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Definition
| Description of procedures, justification for use, species, number, consideration of alternatives, description of housing, justification for withholding analgesics & multiple surgeries, method of euthanasia, provisions for personnel safety & training, etc |
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Term
| What circumstances require a prompt report to the AC Regional Director of APHIS? |
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Definition
| Suspension of an activity by the IACUC involving a USDA-covered species. |
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