Term
| FACTORS THAT REDUCE BIOAVAILABILITY |
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Definition
1. INCOMPLETE DISSOLUTION
2.INCOMPLETE ABSORPTION THRU EPITHELIA
3.BYPASSING ABSORPTIVE AREA
4.PRE-SYSTEMIC METABOLISM
5.CHEMICAL DEGRADATION |
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Term
| DRUG FUNC GRPS SUSCEPTIBLE TO OXIDATION |
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Definition
PHENOLS
POLYUNSATURATED HYDROCARBONS
CATECHOLS
THIOLS
TERTIARY AMINES |
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Term
| DRUG FUNC GRPS SUSCEPTIBLE TO HYDROLYSIS |
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Definition
LACTAMS
LACTONES
AMIDES
ESTERS |
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Term
| THESE ACT AS BUFFERS ANTIOXIDANTS CHELATORS FLOCULATING AGENTS |
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Definition
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Term
| THESE ARE MOSTLY FOR GELLING POLYMERS SUSPENDING, VISCOSITY MODIFIER |
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Definition
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Term
| tHESE MAINTAIN STABILITY IN DRUGS SUSCEPTIBLE TO OXIDATION |
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Definition
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Term
| FOR MULTI USE DRUGS SUSCEPTIBLE TO MICROBIAL GROWTH |
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Definition
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Term
| CAN CHANGE A SOLVENT'S POLARITY TO BETTER MATCH A DRUGS POLARITY AND IMPROVE SOLUBILITY |
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Definition
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Term
| HELPS SOLUBILIZE RXX, ADSORBS AT INTERFACE OF 2 PHASES |
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Definition
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Term
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Definition
· Benzalkonium chloride (BAC)
· Polyquad or polyquaternium 1
· Thimerosal
· Chlorobutanol 0.5%
· Oxidants 1) sodium perborate 2) purite or stabilized oxcychloro complex
parabens, benzoic acid, benzalkonium chloride |
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Term
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Definition
· Microcrystalline cellulose
carboxymethycellulose |
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Term
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Definition
· acetate
· acetic acid
· phosphate
· citrate
· borate
· monobasic and dibasic sodium phosphate (buffer combination)
phosphates, citrates, NaOH, HCl |
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Term
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Definition
· NaCl
· Mannitol (also cooling agent)
dextrose |
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Term
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Definition
· glycerin
· cellulose derivatives like hydroxyethylcellulose
· polyvinyl alcohol
· PEGs
carbomer |
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Term
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Definition
· sodium metabisulfites
sulfites, ascorbic acid, tocopherols, BHA (butylated hydroxyl anisole) |
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Term
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Definition
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Term
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Definition
· Polysorbate or Tween 80
· Tyloxapol
· Oleic acid
· Soya lecithin
· Povidone
polysorbates, phospatidylcholines, Cremophor |
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Term
| Gelling Agents to increase viscosity |
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Definition
· EDTA disodium
· Carbomer 934p
Hypromellose |
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Term
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Definition
· Ethanol
· Glycerin
· Propylene glycol
ethanol, glycerin/glycerol, propylene glycol, PEG 400 |
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Term
| ANION SALTS ARE USED WITH _____ |
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Definition
BASIC DRUGS
HCl
MESYLATE
SUCCINATE
CITRATE
MALEATE
TARTRATE
SULFATE |
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Term
| ACIDIC DRUGS ARE USED WITH______ |
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Definition
CATIONS
SODIUM
POTASSIUM
CALCIUM |
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Term
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Definition
· Atridox
· Arestin
Actisite |
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Term
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Definition
CERVIDIL(SWELLABLE MATRIX)
Nuvaring
Estring
(vaginal rings) |
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Term
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Definition
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Term
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Definition
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Term
| Iontophoresis or electrotransport |
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Definition
ZECUITY (SUMATRIPTAN)
IONYSYS (PT CONTROLLED FENTANYL)
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Term
| TRANSDERMAL (Adhesive Matrix) |
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Definition
· Nitro-Dur
· Minitran
· Climara(7 DAY PATCH)
· Testoderm(APPLIED TO SCROTUM)
· Duragesic(FENTANYL)
· Daytrana (METHYLPHENIDATE)
· Ortho Evra (Q 7 DAYS FOR 3 WKS, THEN 7 DAYS OFF)
· Lidoderm (POST HERPETIC NEURALGIA)
Flector (DICLOFENAC) |
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Term
TRANSDERMAL
MEMBRANE CONTROLLED RESERVOIR |
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Definition
· Transderm-nitro
· Estraderm
· Androderm
Testoderm |
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Term
TRANSDERMAL
MEMBRANE-MATRIX HYBRID |
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Definition
CATAPRESS TTS
TRANSDERM SCOP(SCOPOLAMINE---BEHIND EAR) |
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Term
| Ion exchange systems uses Pennkinetic system |
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Definition
TUSSIONEX SUSP
DELSYM SUSP |
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Term
| ADDED TO ADJUST pH OF DRUG TO OPTIMIZE SOLUBILITY |
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Definition
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