Term
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Definition
-Plays a role in the conversion of plans for movement (the go or no go)
-Major Structures: caudate nucleus, putamen, globus pallidus
-Afferents (inputs): thalamus (excitatory), substantia nigra (dopamine), association of the motor cortex, raphe nucleus (serotonergic)
-Efferents (output): substantia nigra, motor cortex via thalamus |
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Term
Direct Pathway of the Basal ganglion |
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Definition
-Activates the thalamus which talksa to the motor cortex which sends command cells down the PTN
-Uses a neurotransmitter (inhibitory GABA): The striatum inhibits the globus palladus which is normally inhibiting the thalamus. So, inhibition of inhibition causes excitation.
-Increases the likelihood of movement |
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Term
Indirect Pathway of the basal ganglion |
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Definition
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Term
Diseases of the basal ganglion |
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Definition
Parkinson's Disease: lesion of the substantia nigra results in low dopamine levels, this causes a resting tremor and bradykinesia
Huntington's Disease: genetic defect of GABA neurons, chorea: flick like movements, can't stop or start movements |
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Term
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Definition
-"little brain" sits on on top of brain- connected to the brain, the brain stem, and the spinal cord
-major structures: cortex and nuclei
-Input: brain stem specific info (climbing fibers) and info from multiple places/diffuse info (mossy fibers)
-Output: purkinje cells are inhibitory to motor centers via the cerebellar nuclei (except the vestibular nuclei) |
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Term
Functions of the cerebellum |
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Definition
-"Ballistic movements"- rate, range, force, and direction of movement
-Responsible for smooth muscular movement
-Correlation of posture and movement to maintain balance and equilibrium |
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Term
Diseases of the cerebellum |
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Definition
Past pointing: asynergy
Intension temor
Hypotonus |
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Term
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Definition
-staging center where movement programs initiated in other areas converge
-Transmits motor programs via the pyramidal tract to the spinal cord
-The Homunculus: somatotopic organization- hands and face have larger regions
-Major structures: primary motor cortex, supplemental motor area, pre-motor area, and frontal eye fields
-Afferents: many sources including the thalamus, cerebellum, corpus callosum, and basal ganglia
-Efferents: pyramidal pathways and extrapyramidal pathways |
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Term
Diseases of the motor cortex |
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Definition
-A stroke, decreases blood supply to the staging area- so there is contralateral paralysis
-Jacksonian seizure: seizure activity begins with the fingers on one hand, spreads to the hands, arms, and eventually the whole body- this is due to the homunculus |
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