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Connective Tissue Dysfunction Definitions
Basic Definitions for Connective Tissue Dysfunction
28
Pathology
Undergraduate 2
09/25/2011

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Term
Avascular necrosis
Definition
necrosis of bone caused by ischemia
Term
Baker's cyst
Definition
cystic swelling within the popetial space posterior to the bone as a result of mech. irritation or synovial inflamm.
Term
Cytokines
Definition
proteins secreted by a variety of cells to help regulate imm. responses (ie: interleukin)
Term
Dactylitis
Definition
inflamm. of finger or toe
Term
Dermatomyositis
Definition
Diffuse inflamm. of striated mm. that leads to symmetric proximal mm. weakness with a dermatological component.
Term
Effusion
Definition
Excessive fluid in the jt. resulting from jt. irritation or inflamm. of the synovium.
Term
Enthesitis
Definition
Inflamm. where the ligaments and tendons attach to bone
Term
Gout
Definition
disease characterized by acute episodes of arthritis resulting from deposition of uric acid crystals at the joint or in the surrounding tissues
Term
Hyperuricemia
Definition
Abnl. amount of uric acid in the blood
Term
Immunosuppressive drugs
Definition
Drugs that suppress or interfere with nl. immune response.
Term
Inflammatory arthritis
Definition
Systemic arthritis that involves inflamm. of the synovium of the joint
Term
Interleukin-1 (IL-1)
Definition
Substance from monocytes and macrophages important in the acute phase response
Term
Lupus (SLE)
Definition
Chronic inflamm. autoimmune condition that may affect skin, joints, internal organs (including kidney and heart). Symptoms include fatigue, depression, joint pain
Term
Mauskopt
Definition
Loss of facial expression as the result of tightening/tautness of the skin (from scleroderma)
Term
Myostitis
Definition
Inflamm. of striated mm.
Term
Nephritis
Definition
Inflamm. of kidney
Term
Pannus
Definition
Excessive proliferation of synovial and granulation tissue that invades joint surfaces; causes destruction of joint
Term
Pauciarticular
Definition
Involvement of a few joints
Term
Polymyalgia rheumatica (PMR)
Definition
Condition charac. by stiffness and pain at the shoulder girdle and without weakness; usually seen in women over 50 years of age in conjunction with an elevated erythrocyte sedimentation rate (ESR)
Term
Polymyositis
Definition
Diffuse inflammatory disease of striated mm. that leads to symmetric proximal mm. weakness
Term
Pseudogout
Definition
Synovitis caused by the deposition of Ca pyrophosphate dehydrate crystals resulting in arthritis; articular chondrocalcinosis
Term
Psoriatic arthritis
Definition
A spondyloarthropathy with concomitant psoriasis
Term
Raynaud's phynomenon
Definition
Intermittent vasoconstriction of the distal small arteries, arterioles, and capillaries that results in blanching, erythema, and cyanosis of hands
Term
Tophi
Definition
Deposits of uric acid crystals around the joints
Term
Xerostomia
Definition
dry mouth
Term
Uveitis
Definition
Inflamm. of iris, ciliary body, and choroids, or the entire uvea.
Term
Systemic lupus erythematosus (SLE)
Definition
Systemic inflamm. disease charac. by small vessel vasculitis and a diverse clinical presentation (lupus='wolf')
Term
RA
Definition
Systemic disease charac. by inflammation of hte joint synovium
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