Term
|
Definition
| any disease or condition involving the musculoskeletal system. |
|
|
Term
|
Definition
| Antibodies attack healthy normal cells and tissue. |
|
|
Term
|
Definition
| Inflammation of one or more joints, clinically characterized as either noninflammatory or inflammatory. |
|
|
Term
|
Definition
| In OA when the cartilage and bone begin to erode, the joint spaces narrow and bone spurs form. |
|
|
Term
|
Definition
| Synovial inflammation, common in advance stages of OA. |
|
|
Term
|
Definition
| Partial joint dislocation, which eventually lead to immobility, pain, muscle spasms and localized inflammation. |
|
|
Term
|
Definition
| Continuous grating sensation caused by irregular cartilage, may be felt or heard with ROM. |
|
|
Term
|
Definition
| Tests for joint effusion ( excess joint fluid) in the knees. |
|
|
Term
|
Definition
| In RA, vascular granulation tissue composed of inflammatory cells that erode aticular cartilage and eventually destroys bone. This eventually leads to secondary osteoporosis. |
|
|
Term
|
Definition
| In RA, Inflammation in the blood vessel which can impair blood supply to organs. |
|
|
Term
|
Definition
| Joint stiffness, swelling, pain, and fatigue with generalized weakness and morning stiffness. Anorexia and weight loss is common. With a persistent low grade fever. |
|
|
Term
|
Definition
| In RA, Patient has frequent morning stiffness, which last 45min to several hours after wakening. Joints have synovitis and effusion. |
|
|
Term
|
Definition
| Seen with RA, Causes dry eyes, dry mouth (xerostomia), and a dry vagina. |
|
|
Term
|
Definition
| Seen in RA, characterized by enlarged liver, spleen and leukopenia. |
|
|
Term
|
Definition
| In RA, Characterized by nodules in lungs and pneumoconiosis. As see in coal miners and asbestos. |
|
|
Term
|
Definition
| To remove inflamed synovium. |
|
|
Term
|
Definition
Drugs that slow the progression of RA.
*Methotrexate-immunosupression medication, takes 4-6 weeks to become effective. Monitor LFT's, BUN, Creatinine, CBC. AVOID ALCOHOL. Risk for mouth sours and pneumonia, avoid when pregnant.
*Plaquenil: antimalarial drug, used in initial treatment of mild disease. Monitor eye exam.
*NSAID: short term for inflammation and pain. (Celebrex) |
|
|
Term
| Biological response modifiers BRMs |
|
Definition
for RA, They neutralize the TNF, do not give to patients with TB or MS. (do PPD)
*Embrel/ Remicade / Humira |
|
|
Term
|
Definition
For RA.
*Prednisone: for their fast acting anti inflammatory and immunosupression effects, can be given in high dose until DMARDs or others take effect. |
|
|
Term
| Systemic Lupus Erythematosus SLE |
|
Definition
| A Chronic Progressive, inflammatory connective tissue disorder that can cause major body organs and systems to fail. Characterized by spontaneous remissions and exacerbations. Autoimmune disorder that cause vasculitis. |
|
|
Term
|
Definition
| Muscle atrophy from disuse or invasion by the immune complexes or from chronic steroid therapy. |
|
|
Term
|
Definition
| In SLE muscle pain can occur. |
|
|
Term
|
Definition
| In SLE, Exposure to cold and extreme stress the hand and finger as well as their feet can change several different colors. |
|
|
Term
|
Definition
| Peritoneal involvement that includes abdominal pain in SLE. Monitor for vasculitis that can lead to organ failure. |
|
|
Term
|
Definition
| Decrease in all cell types as seen in SLE , monitor CBC. |
|
|
Term
|
Definition
| Biggest sign of an up coming flare up in SLE. REPORT. Protect skin from UV light. |
|
|
Term
| Scleroderma/ Systemic Sclerosis |
|
Definition
| A chronic inflammatory, autoimmune connective tissue disease that causes hardening of the skin. Leading cause of death is renal issues. Do not respond as well to treatment increase the mortality rate. |
|
|
Term
|
Definition
| Skin thickening on the trunk, face, and proximal and distal extremities. |
|
|
Term
|
Definition
| Thick skin limited to sites distal to the elbows and knees but also involves the face and neck. |
|
|
Term
|
Definition
Calcinosis (calcium deposits)
Raynaud's
Esophageal dysmotility
Sclerodactyly (on the digits)
Telangiectasia (spider like hemangioma) |
|
|
Term
|
Definition
| Joint pain and stiffness commonly seen in SSc. |
|
|
Term
|
Definition
| Systemic disease in which irate crystals deposit in the joints and other body tissue causing inflammation. Also called gouty arthritis. |
|
|
Term
|
Definition
| Most common type and results from one of several inborn error of purine (uric acid) metabolism. Uric acid exceeds the excretion, of which can be inherited. |
|
|
Term
|
Definition
| involves hyperuricemia (excessive uric acid in the blood) cause by another disease. |
|
|
Term
|
Definition
| The depositing or uric acid in the great toe, seen in the acute stage of a gouty attack. The Erythrocyte sedimentation rate increases with the inflammation. |
|
|
Term
|
Definition
| Joint inflammation that is so painful with a uric acid level >8.5. Synovial fluid aspiration with uric acid crystal gives a positive diagnosis. |
|
|
Term
|
Definition
| Tophi can begin to rupture with sever inflammation. Signs are renal calculi or renal dysfunction are also present. |
|
|
Term
| Polymyalgia rheumatica PMR |
|
Definition
| Clinical syndrome characterized by stiffness, weakness, and aching of the proximal musculature (shoulders and pelvic girdle). S/S: low grade fever, arthralgias, fatigue, and weight loss. Stiffness worse in the AM. Increase ESR . Treated with low dose steroids. |
|
|
Term
|
Definition
| round or oval, flat or slightly raised rash seen in lyme disease. Pain and stiffness in the muscles and joints. |
|
|
