Term
| Where does most colorectal cancers arise from? |
|
Definition
|
|
Term
| What type of adenomas are more likely to contain invasive carcinoma than tubular adenomas? |
|
Definition
|
|
Term
| What is almost certain by age 40 in those with familial adenomatous polyposis? |
|
Definition
|
|
Term
| What is the treatment of choice for familial adenomatous polyposis? |
|
Definition
| endoscopy and prophylatic colectomy |
|
|
Term
| What are three hereditary syndromes predisposing pts to colorectal cancer? |
|
Definition
1) familial adenomatous polyposis
2) Hereiditary nonpolyposis colorectal cancer
3) inflammatory bowel disease |
|
|
Term
| colonscopy recommendations for pts with hereditary nonpolyposis colorectal cancer |
|
Definition
| age 20-25 or 10 years younger than youngest age of onset in family, whichever is first |
|
|
Term
| Colonoscopy recommendations for pts with IBD? |
|
Definition
| every 1-2 years after 8 years of disease w/pancolitis |
|
|
Term
| What has the highest risk factor for the development of colorectal cancer? |
|
Definition
|
|
Term
| What decreased the risk of colon cancer by 75%? |
|
Definition
| long-term vitamin with folate usage. |
|
|
Term
| What in post-menopausal women reduced the risk of cancer by 33%? |
|
Definition
| Hormone replacement therapy |
|
|
Term
| What lifestyle factor reduces risk by 40%? |
|
Definition
|
|
Term
| What has the strongest evidence of screening for colorectal cancer? |
|
Definition
|
|
Term
| What is the current American Cancer Society recommendations? |
|
Definition
1) Annual FOBT starting age 50, or
2) Flex Sig every 5 yrs starting age 50, or
3) Annual FOBT and flex sig every 5 years starting age 50, or
4) Double contrast barium enema every 5 years and colonoscopy every 10 years starting age 50 |
|
|
Term
| Characteristics of lesions in the ascending colon? |
|
Definition
1) large
2) ulcerate
3) bleeding causing microcytic/hypochromic anemia |
|
|
Term
| What is the most common site of metastisis for colorectal cancer? |
|
Definition
|
|
Term
| 4 roles of CEA measurement |
|
Definition
1) higher levels associated with worse prognosis
2) measure of the completness of resection
3) monitor tumor recurrence
4) response to tx of metastases |
|
|
Term
| What has the greatest potential for cure with invasive colorectal cancer? |
|
Definition
|
|
Term
| What is the TMN classification and what is it used for? |
|
Definition
T-tumor penetration depth
M-presence of or absence of distant metatsis
N-P/A of lymph node involvment
*for staging and prognosis of colorectal cancer |
|
|
