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Coagulation Factors
Coagulation Factors
14
Medical
Undergraduate 2
03/22/2012

Additional Medical Flashcards

 


 

Cards

Term
Factor I
Definition

aka fibrinogen

 

made in liver

 

protein

 

cleaves into 3 parts, 2 peptides 1 fibrin monomer

Term
Factor II
Definition

aka prothrombin

 

made in liver

 

protein

 

vitamin K dependent

Term
Factor III
Definition

aka tissue factor

 

necessary co-factor to factor VII

Term
Factor IV
Definition
aka calcium
Term
Factor V
Definition

aka plasma accelerating factor

 

protein

 

made in liver

 

short half life

Term
Factor VI
Definition
not used
Term
Factor VII
Definition

aka proconvertin

 

made in liver

 

protein

 

vitamin K dependent

Term
Factor VIII
Definition

aka antihemophilia factor

 

produced by vessel endothelium and possibly the liver

Term
Factor IX
Definition

aka christmas factor

 

made in liver

 

deficiencies lead to hemophilia B

Term
Factor X
Definition

aka Stuart-Prower factor

 

protein

 

made in liver

 

vitamin K dependent

Term
Factor XI
Definition

aka plasma thromboplastic anticendent (PTA)

 

protein

 

activated by contact factor

Term
Factor XII
Definition

aka Hagement factor

 

contact factor

 

stable protein

 

works with other contact factors to activate Factor XI

Term
Factor XIII
Definition

aka firbin stablizing factor

 

form one: platelet generated factor is activated by thrombin

 

form two: plasma fibrin stabilizing factors activated by process needing calcium

Term
Role of Vitamin K
Definition

participates in an oxidation reaction that adds a second carboxyl group to the gamma carbon of glutamic acid residues

 

factor now has two COO- groups

 

binds more securely to calcium

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