injury to vessel wall results in damage to endothelium

basement membrane is exposed and released procagulants

platelets adhere to collagen in the subendothelium

platelets release more procoagulant agents

contact factors activate factor XII

factor XIIa activates factor XI

factor XIa activates factor IX

factor VIIIa "comes along" and forms a complex with factor IXa

tested for with APTT

high molecular weight kinnins (HMWK) are exposted to platelet factor III, form PF3-HMWK complex

pre-kalikrien is exposed to PF3-HMWK comples and becomes kalikrien

kalikrien activates the intrinsic pathway

tissue factor activates factor VII

tested for with PTT

where intrinsic and extrinsic pathways merge

either pathway activates factor X

factor Xa workings with factor Va to convert prothrombin to thrombin

thrombin converts fibrinogen to fibrin