serine protease inhibitor (SERPIN)

neutralizes thrombin and the intrinsic pathway

thrombin interacts with endothelial cell and produces the protein: thrombomodulin

this complex activates protein C zymogen

activated C binds with protein S

C-S complex inactivates factors Va and VIIIa

hydrolytic digestion of cross-linked fibrin polymers

occurs due to inactive proteolytic enyme incorporated into fibrin polymers

90,000 dalton zymogen that binds to fibrin during polymerization

capable of digesting fibrinogen and factors V & VIII

produced and secreted by damaged endothelial cells and initiates fibrinolysis by converting plasminogen to plasmin

binds to fibrin during polymerization

rapidly and irrevesibly binds free plasmin

ensures that fibrinogen and factors V & VIII are not hydrolyzed

fragments of fibrin breakdown to inhibit any more clotting during fibrinolytic process

varities: X, Y, D, E, D-D