Term
biogenic amine therory
(monoamine hypothesis for depression)
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Definition
| Depression is due to a deficiency of monoamines, such as norepinephrine (NE) and serotonin (5HT) at certain sites in the brain |
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Term
| Limitations of the biogenic amine theory |
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Definition
- antidepressant effects are generally not seen until 3 or more weeks of continuous treatment
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Term
| Classes of antidepressants |
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Definition
- Tricyclic antidepressants (TCA)
- selective serotonin reuptake inhibitors (SSRI)
- Serotonin/NE reuptake inhibitors (SNRI)
- atypical antidepressants
- monoamine oxidase inhibitors (MAOI)
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Term
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Definition
- occurs when overdose with a single drug or concurrent use of several drugs, results in excess serotonergic activity in the CNS
- any drug that raises 5HT levels can be an issue (MAOI, SSRI, TCA, SNRI, SSRI-like activity: meperidine, tramadol, dextromethorphan, linezolid)
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Term
| management of serotonin syndorme |
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Definition
- Remove precipitating drugs
- allow at least 14 days to elapse between MAOI discontinuation and TCA, SNRI, or SSRI institution
- supportive care
- control of agitation
- control of autonomic instability
- control of hyperthermis
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