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CLPH Exam I
Common Skin Disorders
44
Pharmacology
Professional
09/29/2011

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Cards

Term
Impetigo
Definition
Topical staph skin infection

most common in children

direct spread

refer to PCP

treat with topical or oral antibiotics
Term
Topical Candida Infection
Definition
common in moist, humid areas

treat with topical anti-fungals and dry the affected area
Term
Tinea pedis (Athlete's foot)
Definition
often spread in pools/showers

moist environments promote growth

dermatophyte infection

treat with topical anti-fungals
Term
Tinea corporis (body ring worm)
Definition
commonly transmitted in day care

hot/humid environments promote growth

small, circular, red, scaly areas

treat with topical antifungals
Term
Head lice (pediculosis)
Definition
children 3 - 12 years old

scalp redness and scaling

pruritis

refer to PCP

treat with:
-Permethrin 1%
-Malathion (Ovide)
-oral Ivermectin (Stromectol)
Term
Scabies
Definition
Sarcopes scabiei infection

primarily in children and adolescents (LTCF)

raised lines caused by mite burrowing into the skin

extreme pruritus

refer to PCP

treat with:
-Permethrin 5%
-Crotamiton (Eurax cream)
-oral Ivermectin (Stromectol)
Term
Herpes zoster (shingles)
Definition
adults > 40 years old

triggered by stress, old age, immunosuppression

extreme pain along the dermatome

tender, red papules - progress to scabs

refer to PCP

treat with:
-oral valcyclovir or famciclovir
-manage acute pain and postherpatic arthralgia
Term
Skin cancer
Definition
basal cell carcinoma (most common)

squamous cell carcinoma (sun exposure)

melanoma (most deadly)

Caucasians with light eye and skin color

refer to PCP

treat with:
-removal of the lesion
-chemotherapy
-radiation
Term
Dry skin (xerosis) Common Features
Definition
fall and winter

feet, lower legs

hands, elbows, face

rough, dry scales, cracks

itching is a common symptom
Term
Dry skin (xerosis) Who is at risk?
Definition
The elderly

Frequent bathers
Term
Dry skin (xerosis) Treatment options
Definition
Emollients
-first line for itching
-restores barrier and skin function

agents for itching

after bathing habits
Term
Dr. Martin's Rule of 3's for dry skin (xerosis)
Definition
Tub bath or shower no more than 3 times per week

tepid water 3 - 5 degrees above body temperature

bathe for 3 - 5 minutes

apply copious amounts of emollients within 3 minutes of showering

apply emollients 3 times daily
Term
Emollients for dry skin (xerosis)
Definition
Vaseline

Nivea

Keri

Eucerin

Lubriderm

AmLactin
Term
Agents to reduce itching in dry skin (xerosis)
Definition
Menthol and camphor
-1/2 - 1%
-create a sensation of cooling

Pramoxine
-1%
-local anesthetic

Hydrocortisone
-1/2 - 1%
-anti-inflammatory
Term
Dermatitis
Definition
inflammation process of the upper two layers of the skin
Term
3 stages of dermatitis
Definition
1. acute
2. sub-acute
3. chronic
Term
Acute Dermatitis
Definition
red patches or plaques

pebbly surface or blister (vesicles)

itching is common
Term
Sub-acute dermatitis
Definition
dry

less red

crusting, oozing

mild thickening
Term
Chronic dermatitis
Definition
epidermal thickening

exaggerated skin marking

lichenification

scaling

less itching
Term
Acute contact dermatitis
Definition
look at pattern

look at part of body involved

main symptom is itching

two types:
-allergic
-irritant
Term
Poison Ivy
Definition
Acute contact dermatitis

direct exposure
-broken plant
-resin - 2 weeks

indirect exposure
-smoke, dog, clothes
-does not spread from lesions

prevention is key:
-Ivy-Block is a protectant/barrier that should be applied every four hours
Term
Poison Ivy (cont.)
Definition
dermatitis occurs 24 - 48 hours after exposure

pruritis is intense
-secondary infections
-cool water

wash skin and nails within 10 minutes - wash clothing as well

topical therapy is ok if less than 10% BSA is involved
Term
Poison Ivy Treatment Options
Definition
Remove source

Soaks

Calamine lotion

Topical antihistamines

Oral antihistamines

Topical corticosteroids

Oral corticosteroids
Term
Irritant Acute Contact Dermatitis
Definition
non-immunologic reaction to frequent contact with everyday substances

reaction within a few hours

common irritants??

more common than allergic

treatment is the same as with poison ivy
Term
General treatment principles for dermatitis
Definition
stop the itch-scratch cycle

must understand the patient's personality, social, and domestic conditions

ability to carry out treatment

no one therapy is best for every patient
Term
Use of soaks to treat acute dermatitis
Definition
use for oozing, weeping lesions

wet dressings are useful for drying acutely inflamed, wet areas
Term
Treatment of acute contact dermatitis
Definition
Domeboro (5% aluminum acetate)
-packets in cool water

Acetic acid: 60 mL of vinegar per 1 qt of warm water

Water

Saline: 1 tsp of salt in 2 cups water

Apply linen or cheesecloth for 30 minutes twice to four times daily; remove when dry
Term
Mechanism of action of topical corticosteroids for acute dermatitis
Definition
anti-inflammatory

anti-pruritic

suppress immune response
Term
Topical corticosteroids for acute dermatitis
Definition
apply twice to four times daily for 3 - 14 days

choice of vehicle depends on type of dermatitis
Term
Choice of topical corticosteroid agent for acute dermatitis
Definition
Choice is based upon:
-location of lesions
-types of lesions
-severity of lesion/degree of inflammation
-degree of skin penetration desired
Term
Classification of Topical Corticosteroids
Definition
Classified according to the anti-inflammatory and vasoconstricive potency

High - Mid - Low (Grades I to VII)
Term
Side effects of topical corticosteroids
Definition
thinning of skin

dilated blood vessels

bruising

skin color changes

risk of HPA suppression with long term use of high-potency agents

development of tolerance (tachyphylaxis)
Term
Low Potency Topical Corticosteroids
Definition
Grades V - VII

Hydrocortisone
Hytone
Cortaid
Desonide
Aclovate

use on:
-face
-groin
-genital
-axilla

mild anti-inflammatory effect

safest for long term use
Term
Mid-potency Topical Corticosteroids
Definition
Grades II - V

Vasilone
Diprosone
Kenalog
Cordran

used on most skin surfaces

moderate anti-inflammatory effect

safer for longer use than high potency
Term
High/Very-high Potency Topical Corticosteroids
Definition
Grades I - II

Lidex
Ultravate
Psorcon
Temovate

use for very severe lesions and on thickened skin when maximum penetration is needed

do NOT use on the face

avoid using super-potent for more than 2 weeks

Limit to 50 g per week
Term
Topical Calcineurin Inhibitors
Definition
MOA: blocks pro-inflammatory cytokines

can be used on any area

equivalent to mid-potency corts

no risk of atrophy

few side effects

very expensive

Elidel cream 1%
Term
Concerns with topical calcineurin inhibitors
Definition
now considered 2nd line therapy

intermittent use only

recent concern regarding long term use
-risk of malignancies
-risk of respiratory infection in children less than 2 years old
Term
Systemic corticosteroids for acute dermatitis
Definition
Avoid dose-packs - do not provide long enough period of time

start at prednisone 40 - 60 mg per day, taper every 3 days

minimum of 10 - 14 days of treatment
Term
Systemic Non-sedating antihistamines for acute dermatitis
Definition
Allegra (fexofenadine)

Claritin (loratadine)

Clarinex (desloratadine)

Sedating (Benadryl) are useful at night
Term
Sub acute dermatitis
Definition
red scaling, fissured patches or plaques

slight to moderate pruritis, pain, stinging or burning
Term
Sub acute Atopic Dermatitis
Definition
most common form of eczema

usually presents in infancy
-1 in 5 children
-1 in 12 adults

strong genetic link
-2/3 will also develop asthma or allergic rhinitis

prone to infections due to scratching

usually staph aureus

treat with antibiotics
Term
Sub acute Atopic Dermatitis Clinical Presentation
Definition
Pruritis

Red patches or plaques

scaling exoriations

overall dryness of the skin

redness and inflammation

common locations:
-folds of elbows/knees
-face commonly involved in children
-adult is more widespread
Term
Triggers of Sub acute Atopic Dermatitis
Definition
Allergens
Chemicals
Detergents
Bathing
Smoke
Dust
Infections
Term
Treatment of Sub Acute Atopic Dermatitis
Definition
Emollients and Education

Topical corticosteroid

Topical calcineurin inhibitor

Antihistamines at night

Systemic treatment:
-only when topical fails

Avoid chronic treatment if possible
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