Term
|
Definition
-constant percentage of drug eliminated per unit time
-how most drugs are eiliminated |
|
|
Term
|
Definition
time to reduce plasma levels by one half |
|
|
Term
|
Definition
how many half lives does it take to reach a steady state? |
|
|
Term
capacity limited (zero order) elimination |
|
Definition
-constant amount of drug eliminated per unit time
-can cause drug accumulation |
|
|
Term
|
Definition
regulatory proteins that interact with a drug or hormone and initiate a cellular response |
|
|
Term
|
Definition
-dose that works in 50% of the population 50% of the time.
-threshold dose |
|
|
Term
|
Definition
dose below which, no response |
|
|
Term
|
Definition
half of possible maximum response |
|
|
Term
|
Definition
does to produce 1/2 of the possible maximum response: ED50 |
|
|
Term
|
Definition
|
|
Term
|
Definition
|
|
Term
intrinsic activity (i.a.) |
|
Definition
___________- the ability to produce a response |
|
|
Term
|
Definition
|
|
Term
|
Definition
Agonists also have ________ and _________ |
|
|
Term
|
Definition
how well the drug fits into binding sites |
|
|
Term
|
Definition
how well the drug turns on the receptor after binding |
|
|
Term
|
Definition
a partial agonist in the presence or a full agonist is an ___________ |
|
|
Term
|
Definition
drugs that interact with a receptor to produce a response |
|
|
Term
|
Definition
these can produce the full response I.A.= 1 |
|
|
Term
|
Definition
these can produce a response less than that of full agonists. I.A> 0 and <1 |
|
|
Term
|
Definition
these have affinity, no intrinsic activity, block the binding by an agonist to its receptor, blockade can be overcome, and reduce the potency of the agonist |
|
|
Term
|
Definition
how well the drug turns on receptors |
|
|
Term
|
Definition
how well a drug relieves symptoms |
|
|
Term
|
Definition
what is the formula for the therapeutic index? |
|
|
Term
|
Definition
What is the formula for the certain safety index? |
|
|
Term
|
Definition
the difference between the therapeutic effect and the lethal effect. The further apart the curves are, the safer the drug. |
|
|
Term
|
Definition
This tells you how far apart the tails of the curves are, the bigger the number, the safer the drug. |
|
|