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Clinical Pathology II
Final Exam
161
Veterinary Medicine
Undergraduate 3
04/17/2013

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Cards

Term
What does ALT stand for?
Definition
Alanine Aminotransferase
Term
What is Alanine Aminotransferase?
Definition
Liver enzyme
Term
What 3 things can affect a ALT test?
Definition
Hemolysis (increase), Lipemia (increase), and cephalosporins
Term
What can be indicated by a high ALT test?
Definition
Hepatocellular injury and septicemia
Term
How do corticosteroids and anticonvulsant medications affect a ALT test?
Definition
Increase levels
Term
What's a normal range for canine/feline ALT tests?
Definition
5-109 U/L & 5-97 U/L
Term
What do increased levels of ALT/SCPT indicate?
Definition
Liver disease, but not severity
Term
T/F ALT is the same thing as SGPT.
Definition
True
Term
What does ALB stand for?
Definition
Albumin
Term
What is albumin?
Definition
Liver enzyme
Term
What 4 things can affect a ALB test?
Definition
Hemolysis (increase), Lipemia (increase), bilirubin, and dehydration
Term
What 3 things can increased albumin indicate?
Definition
Immune-mediated diseases, infections, and neoplasia
Term
What do low levels of albumin indicate?
Definition
Bleeding somewhere
Term
What's a normal range for canine/feline ALB tests?
Definition
2.3-4.3 g/dL & 2.6-4.0 g/dL
Term
What does ALKP stand for?
Definition
Alkaline Phosphatase
Term
What is Alkaline Phosphatase?
Definition
A liver enzyme
Term
What 3 factors can affect ALKP tests?
Definition
Hemolysis (increase), Lipemia (increase), and steroids
Term
What 2 disease can a high ALKP test indicate?
Definition
ZBiliary system and cholestasis
Term
What will happen if a ALKP test is left out for 24 hours?
Definition
Levels will increase
Term
What 2 anticoagulants should be avoided with ALKP and AMYL tests?
Definition
EDTA and oxalate anticoagulants
Term
What enzyme is produced by bile stasis and is found in the liver and bone?
Definition
ALKP
Term
What's a normal range for canine/feline ALKP tests?
Definition
10-114 U/L & 10-70 U/L
Term
What does an increase of ALKP indicate in cats?
Definition
Significant cholestasis
Term
Cushings, pregnancy, and young animals can have increased levels of what?
Definition
Alkaline Phosphatase
Term
What does AMYL stand for?
Definition
Amylase
Term
What is amylase?
Definition
Pancreatic enzyme
Term
What 3 things can affect a AMYL test?
Definition
Hemolysis (increase), Lipemia (increase), and corticosteroids (decrease)
Term
What can increased levels of AMYL indicate?
Definition
Pancreatitis and Liver cancer
Term
What breaks down starches and glycogen in sugars?
Definition
Amylase
Term
What's a normal range for canine/feline AMYL tests?
Definition
220-1500 U/L & 28-1500 U/L
Term
What does TBILI stand for?
Definition
Total Bilirubin
Term
Where is bilirubin produced?
Definition
Liver
Term
What 2 factors affect the accuracy of results for TBILI?
Definition
Hemolysis and lipemia (increase)
Term
What can increased levels of TBILI indicate?
Definition
Jaundice and liver disease
Term
Whhat is a byproduct of hemaglobin breakdown?
Definition
Bilirubin
Term
What is unconjugatedly bound to albumin and travels to the liver?
Definition
Bilirubin
Term
Conjugated what is secreted in bile?
Definition
Bilirubin
Term
What's a normal range for canine/feline TBILI tests?
Definition
0-0.6 mg/dL
Term
What do increased levels of conjugated TBILI indicate?
Definition
Liver disease
Term
What type of bilirubin is found in urine?
Definition
Conjugated
Term
What is BUN?
Definition
Blood Urea Nitrogen
Term
What organ do BUN affect?
Definition
Kidneys
Term
What 2 factors can affect the accuracy of a BUN test?
Definition
Hydration status (increase) and high protein diets (increase)
Term
What 2 things can a high BUN indicate?
Definition
Kidney disease/damage and congenitive heart failure
Term
What test requires 75% of kidneys to have failed before elevated results are noticed??
Definition
BUN
Term
What test must interpreted with SG?
Definition
BUN
Term
What effect do contaminants from urease-producing bacteria have on BUN tests?
Definition
Decrease
Term
What's a normal range for canine/feline BUN tests?
Definition
6-29 mg/dL & 10-35 mg/dL
Term
What does an elevated BUN with normal SG indicate?
Definition
Dehydration
Term
What does an elevated BUN with low SG indicate?
Definition
Renal disease
Term
What does CHOL stand for?
Definition
Cholesterol
Term
What 3 things do cholesterol affect/are produced?
Definition
Thyroid, liver, and kidney
Term
What 2 things affect the accuracy of CHOL tests?
Definition
Hemolysis (increase) and corticosteroids
Term
What 3 diseases are indicated by high CHOL test?
Definition
Hypothyroidism, pancreatitis, and kidney disease
Term
What 2 anticoagulants can increase CHOL??
Definition
Fluoride and oxalate
Term
What is excreted in bile and is important for fat absorption from the intestines?
Definition
CHOL
Term
What combines with protein to form lipoproteins, which transport triglycerides in blood?
Definition
CHOL
Term
What's a normal range on canine/feline CHOL tests?
Definition
116-330 mg/dL & 50-175 mg/dL
Term
What's a steroid used to form sex and adrenal hormones?
Definition
CHOL
Term
T/F CHOL is a good diagnostic test.
Definition
False
Term
What's CK (CPK)?
Definition
Creatine kinase (Creatine phosphokinase)
Term
What affects skeletal muscle, cardiac muscle, and the brain?
Definition
CK (CPK)
Term
What 2 factors can affect the accuracy of CK (CPK) tests?
Definition
Severe hemolysis (increase) and icterus sample (increase)
Term
What does an abnormal CK (CPK) test indicate?
Definition
Muscle damage
Term
What effect do oxidizing agents have on CK (CPK) tests?
Definition
Increase
Term
What effect does sunlight exposure have on CK (CPK) tests?
Definition
Decreased levels
Term
What's a normal range on canine/feline CK (CPK) tests?
Definition
40-368 U/L & 50-362 U/L
Term
What test differentiates between AST liver vs muscle disorders?
Definition
CK (CPK)
Term
What does CREAT stand for?
Definition
Creatinine
Term
What organ does creatinine originate from?
Definition
Kidneys
Term
Hydration status of patient, exercise can mildly increase, active muscle wasting can mildly increase, and meat diets can mildly increase levels on what test?
Definition
CREAT
Term
What can high CREAT levels indicate?
Definition
Kidney damage
Term
What is a byproduct of energy stores in muscle?
Definition
Creatinine
Term
What is filtered by glomeruli, but is not reabsorbed so it provides an index of GFR?
Definition
Creatinine
Term
What's a normal range for canine/feline CREAT tests?
Definition
0.5-1.7 mg/dL & 0.7-2.2 mg/dL
Term
What does decreased SG mean on a CREAT test?
Definition
Renal cause
Term
What does high SG on CREAT tests indicate?
Definition
Prerenal or postrenal causes
Term
What does GGT stand for?
Definition
Gamma-glutamyl transpeptidase
Term
Where does GGT originate?
Definition
Liver
Term
What 3 things can affect the accuracy of a GGT test?
Definition
Lipemia (decreases), corticosteroids (increase), and anticonvulsants (increase)
Term
Prolonged contact with erythrocytes can affect results in what tesst?
Definition
GGT
Term
What's a normal range for canine/feline GGT tests?
Definition
2-10 U/L & 1-8 U/L
Term
What type of animals are GGT tests mainly used on?
Definition
Large animals
Term
What does GLU stand for?
Definition
Glucose
Term
Where is lipase produced?
Definition
Pancreas
Term
What 2 things can affect the accuracy of GLU tests?
Definition
Stress and not separating serum from erythrocytes
Term
Where is glucose processed?
Definition
Liver and pancreas
Term
What can high GLU tests indicate?
Definition
Diabetes mellitus
Term
What test can drop by 10% per hour if left on the erythrocytes?
Definition
Glucose
Term
What is an energy source for all cells?
Definition
Glucose
Term
What's a normal range for canine/feline GLU tests?
Definition
65-130 mg/dL & 58-125 mg/dL
Term
What's converted from ingested carbohydrates or synthesized from protein or hepatic glycogen?
Definition
Glucose
Term
What does LIP stand for?
Definition
Lipase
Term
What 2 factors can affect the accuracy of LIP tests?
Definition
Lipemia (increase) and hemolysis
Term
What 2 diseases are indicated from increased lipase?
Definition
Pancreatitis and liver cancer
Term
What 2 anticoagulants should be avoided with LIP tests?
Definition
EDTA and oxalate
Term
What's a normal range for canine/feline LIP tests?
Definition
0-425 U/L & 0-200 U/L
Term
What breaks down long-chain fatty acids of lipids?
Definition
Lipase
Term
What effect do corticosteroids have on LIP tests?
Definition
Increases levels
Term
What does PHOS stand for?
Definition
Phosphorus
Term
What organ processes phosphorus?
Definition
Kidneys
Term
What 2 things can affect the accuracy of PHOS tests?
Definition
Lipemia (increase) and hemolysis (increase)
Term
What can abnormal PHOS levels indicate?
Definition
Kidney disease
Term
Diet and not separating serum from erythrocytes can cause abnormal values on what test?
Definition
PHOS
Term
What's a normal range for canine/feline PHOS tests?
Definition
2.5-6.2 mg/dL & 2.5-7.3 mg/dL
Term
Increase in ____ = decrease in phosphorus.
Definition
Calcium
Term
Decrease in _____ = increase in phosphorus.
Definition
Calcium
Term
What's TP stand for?
Definition
Total protein
Term
What 2 organs affect TP levels?
Definition
Liver and kidneys
Term
What 3 things can affect the accuracy of TP?
Definition
Lipemia (incr.), hemolysis (incr.), and dehydration of sample (incr,)
Term
What can abnormal TP tests indicate?
Definition
Liver & kidney disease
Term
What is made up of albumin and globulin?
Definition
TP
Term
The presence of what can raise TP levels?
Definition
Fibrinogen
Term
What's a normal range for canine/feline TP tests?
Definition
5.4-7.6 mg/dL & 2.5-7.3 mg/dL
Term
What's the only reason for an increase in albumin?
Definition
Dehydration
Term
What increase from antigenic stimulation and multiple myeloma?
Definition
Globulins
Term
Where is uric acid processed?
Definition
Kidneys
Term
What 2 factors can affect the accuracy of uric acid tests?
Definition
Post-prandial samples (increase) and toenail samples contaminated due to fecal urate (on birds)
Term
What does increased uric acid levels indicate?
Definition
Kidney disease (in birds & dalmations)
Term
What is the end product of amino acid breakdown?
Definition
Uric acid
Term
What is synthesized by the liver and excreted by the kidneys?
Definition
Uric acid
Term
What's a normal range for feline uric acid tests?
Definition
2-15 mg/dL
Term
What's a normal range for canine uric acid tests?
Definition
2-15 mg/dL
Term
What SGPT stand for?
Definition
Serum Glutamic Pyruvic Transminase
Term
What 3 things can affect a SGPT test?
Definition
Hemolysis (increase), Lipemia (increase), and cephalosporins
Term
What can be indicated by a high SGPT test?
Definition
Hepatocellular injury and septicemia
Term
What's a normal range for canine/feline SGPT tests?
Definition
5-109 U/L & 5-97 U/L
Term
What organ are ALT/SGPT, ALB, ALKP, TBILI, CHOL, GGT, GLU, and TP tests used to detect problems with?
Definition
Liver
Term
What organ are AMYL, GLU, and LIP tests used to detect problems with?
Definition
Pancreas
Term
What organ are BUN, CHOL, CREAT, Uric Acid, and TP tests used to detect problems with?
Definition
Kidneys
Term
What test can detect thyroid problems?
Definition
CHOL
Term
What test can detect problems with skeletal muscle, cardiac muscle, and brain tissue?
Definition
CK (CPK)
Term
What's another name for reference range?
Definition
Normal range/values
Term
How are globulin levels calculated?
Definition
Minus albumin
Term
What are 2 tests that test pancreatic function?
Definition
AMYL and LIP
Term
An increased ALKP can be expected in what type of animal?
Definition
Young or pregnant animals
Term
What type of azotemia is caused by the inability to urinate?
Definition
Postrenal azotemia
Term
What the byproduct of the breakdown of hemaglobin?
Definition
Bilirubin
Term
SGPT aka?
Definition
ALT
Term
What kidney value is much less affected by diet and protein catabolism?
Definition
Creatinine
Term
What are 4 types of samples?
Definition
CBC, Chemistry, Urine culture, cytology
Term
What's the primary purpose of cytology?
Definition
To differentiate between inflammation and neoplasia
Term
What's histopathology?
Definition
Observing cells in relation to neighboring cells
Term
What are 5 types of sample collection?
Definition
Swabs, scraping, inprint, biopsy, and centesis
Term
How would you collect an ear or vaginal cytology?
Definition
Swab
Term
What would you use to collect mites or a biopsy?
Definition
Scrape
Term
How would you collect scab samples?
Definition
Imprints
Term
How do you fix cells to a slide?
Definition
95% methanol for 2-5 minutes
Term
What type of cytological stain does the organisma and cytoplasm stain well?
Definition
Romanowsky type (diff quick)
Term
What type of cytological stain is there excellent nuclear detail, but it's a time-intensive technique?
Definition
Papan stain (trichrome)
Term
How do you tell if a neoplasia is malignant?
Definition
3 or more types of abnormal nuclear configurations
Term
What is the variability of cell size?
Definition
Anksokaryosis
Term
What's variability in size and shape of same cell type?
Definition
Leomorphism
Term
What's another name for epithelial cell tumors?
Definition
Carcinoma or adenocarcinoma
Term
What's another name for mesenchymal cell tumor?
Definition
Sarcoma
Term
What are 5 round-cell tumors?
Definition
Histiocytoma, lymphoma, mast cell tumors, venereal tumors, and melenoma
Term
What means cancerous: Fibroma or fibrosarcoma?
Definition
Fibrosarcoma
Term
When would you see non-cornified cells?
Definition
Diestrus, anestrus
Term
What stage do cornified cells increase by 10% a day and there may be some red blood cells?
Definition
Proestrus
Term
When is there almost 100% cell cornification?
Definition
Estrus
Term
When stage do cells decrease from 100% cornified to 50% cornified in one day?
Definition
Diestrus
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