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Clinical Lab
Carbohydrates
71
Medical
Graduate
08/30/2010

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Cards

Term
apolipoproteins
Definition
What is used as a means to evaluate risk of atherogenic heart disease or peripheral vascular disease?
Term
apolipoproteins
Definition
Protein component of lipoprotein is composed of several polypeptides called what?
Term
lipoproteins
Definition
What do apolipoproteins bind to the receptors on cell surfaces?
Term
apolipoproteins
Definition
What facilitates lipid uptake in cells?
Term
hormones
Definition
What helps to regulate glucose movement in and out of cells?
Term
Insulin
Definition
What hormone decrease blood sugar?
Term

1.  Increased or decreased metabolism of carbohydrates into sugar

2. Increased/decreased rate of consumption of glucose by cells

 

3. Hormones help to regulate glucose movement into and out of cells 

Definition

In which ways does blood glucose change?

(3 ways)1

Term
glucagon, cortisol, epinephrine, growth hormone
Definition

Which hormones increase blood sugar?

(4 of them)

Term
70-115 mg/dl
Definition
What is a normal fasting glucose?
Term
>105 mg/dl
Definition
What is a normal fasting glucose in a pt with gestational diabetes?
Term
>140 mg/dl
Definition
What is a normal fasting glucose for a pt with non-gestational diabetes?
Term
high glycosylated hemoglobin level
Definition
What level indicates poor control in diabetes?
Term
<6%
Definition
What is the normal non-diabetic level of glycosolated hemoglobin?
Term
Glycosylated Hemoglobin
Definition
What test is used to monitor diabetic therapy and differentiate short term hyperglycemia from a diabetic condition?
Term
glycosylated hemoglobin
Definition
Which test could be used to determine if a pt is lying about their diabetes control?
Term

1. triglycerides

2. total cholesterol

3. HDL

4. LDL

5. Chol:HDL ratio

Definition

Which lipids are included in a lipid panel?

(there are 5)

Term
<150 mg/dl
Definition
What is a normal triglyceride level of a lipid panel?
Term
<200 mg/dl
Definition
What is a normal total cholesterol level of a lipid panel?
Term
>40 mg/dl
Definition
What is a normal HDL level of a lipid panel?
Term
<130 mg/dl
Definition
What is a normal LDL level of a lipid panel?
Term

<5

 

*(lower is better)

Definition
What is a normal Chol:HDL ratio of a lipid panel?
Term

Changes with fasting: tryiglycerides

Does not: Total Cholesterol

Definition

What part of the lipid panel changes with fasting state?

 

Which does not?

Term
hyperproteinemia
Definition
Dehydration, gammopathies, liver disease and collagen disorders all tend to cause what?
Term
hypoproteinemia
Definition
Increased protein loss, increased catabolism, decreased synthesis all cause what?
Term
hypoproteinemia
Definition

nephrotic syndrome, burns, inflammation, malignancy, liver disease, decreased amino acid intake

 

All of these diseases can cause what?

Term
creatinine kinase
Definition
What is involved in the conversion of creatinine phosphate to creatinine in muscle contraction?
Term
CKMB (creatinine kinase myocardial bands)
Definition
What rises 3-6 hours after a MI?
Term
12-24 hrs.
Definition
CKMB peaks after a MI how long after?
Term
12-48 hours
Definition
How long after a MI will CKMB normalize?
Term
Myocardial Bands (MB)
Definition
What does not usually rise in transient chest pain caused by angina, PE or CHF?
Term

1. unstable angina

2. shock

3. malignant hyperthermia

4. myocarditis

Definition

What will cause an increase in CKMB?

(there are 4)

Term
Troponins
Definition
What levels are more accurate for cardiac muscle injury?
Term
Troponins
Definition
Which levels will always be normal in non-cardiac injury?
Term
10-14 days
Definition
Troponin T remains elevated for how many days?
Term
TN-I
Definition
Which troponin levels remain elevated for 7-10 days?
Term
troponin
Definition
Getting which levels are not helpful for reinfarct?
Term
Cytoplasmic changes
Definition
What kind of changes in the liver is associated with rises in LDH, AST, ALT?
Term
cytoplasmic
Definition
Injury resulting in cell death results leads to leakage in ______ enzymes.
Term
AST
Definition
Which enzyme is associated with mitochondria?
Term
ALP, GGT
Definition
Which enzyme are associated with canalicular?
Term
canalicular
Definition
An obstructive process and accumulation of bile acids releases ____________ enzymes.
Term
AST
Definition
What is elevated following MI but also can be elevated following liver disease or injury?
Term
AST
Definition
What is elevated with cirrhosis, liver tumor or abcess, drug or ETOH damage, or hepatitis?
Term
AST
Definition
What is a good indicator of acute liver cell damage?
Term
ALT
Definition
Most elevations of this are due to liver disease?
Term
alcoholic liver disease, active cirrhosis
Definition

ALT is less elevated than AST in what diseases?

(2 of them)

Term
ALT
Definition
What is used to confirm that AST elevation is due to liver injury?
Term

longer

 

*b/c of half life

Definition
Does ALT remain elevated longer or shorter than AST?
Term
GGT
Definition
What is not significantly elevated with normal ETOH use, but is elevated with chronic use and binge drinking?
Term
alcoholism
Definition
GGT is advocated as a screeing test for what?
Term
GGT
Definition
What can be used to confirm whether ALP is  b/c of liver disease or not?
Term

Cancer

 

*gallstones is second

Definition
If a 65 y/o pt has an increase in bilirubin, what is your first suspicion?
Term
Viral infection, ETOH, & gallstones are all equal
Definition
A 45 y/o pt has an increase in bilirubin, what is the most common cause?
Term
viral causes
Definition
What is the most common cause for an increase in bilirubin in a pt under 30 y/o?
Term
total bilirubin
Definition
A normal level of what rules out any significant impairment of the excretory function of the liver or excessive hemolysis of RBC's?
Term
>15 mg/dl
Definition
What is a critical value of bilirubin in newborns?
Term
>12 mg/dl
Definition
What is a critical adult value for bilirubin?
Term
Amylase
Definition
What is secreted from pancreatic cells from the pancreatic duct?
Term
amylase
Definition
What aids in catabolism of carbohydrates in the intestine?
Term
amylase
Definition
What is used to monitor and detect the pancreas?
Term
Amylase
Definition
What would you order with a pt who present with acute abdominal pain?
Term
12
Definition
Abnormal levels of amylase rise within how many hours of onset of disease?
Term
48-72 hrs
Definition
How many hours after the disease onset do the amylase levels clear?
Term
Lipase
Definition
What is secreted by the pancreas into the duodenum to break down triglycerides?
Term
the kidney
Definition
What is lipase excreted by?
Term
acute pancreatitis
Definition
In what disease do lipase levels parallel the rise in amylase, but then rise later?
Term
a. sensitive, specific
Definition

 Lipase is less ______ but more _____ than amylase as an indicator of pancreatitis.

a. sensitive, specific

b. specific, sensitive

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