Term
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Definition
Mean Corpuscular Volume (MCV)
Mean Corpuscular Hemaglobin (MCH)
Mean Corpuscular Hemoglobin Concentration (MCHC) |
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Term
| Mean Corpuscular Volume (MCV) |
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Definition
Measure of the size or volume of the average RBC
may be high or low in the absence of true anemia
Alcoholism
Megaloblastic Anemia (early)
Drug induced Marcocytosis
Based on the MCV anemia is classified as:
Microcytic
Normocytic
Marcocytic |
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Term
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Definition
decrease in RBC volume (<80 fL)
Most common cause is iron deficiency |
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Term
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Definition
| Normal RBC volume (80 – 96 fL) |
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Term
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Definition
Elevation in RBC volume (> 96 fL)
Most common cause is alcoholism |
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Term
| Mean Corpuscular Hemoglobin (MCH) |
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Definition
Weight of HB in the average cell
Reference range (26 – 34 pg)
Changes parallel the MCV |
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Term
| Mean Corpuscular Hemoglobin Concentration (MCHC) |
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Definition
The amount of hemoglobin in the average RBC when compared to its size
Men
31 to 37 g/dL
Women
30 to 36 g/Dl
50% of patients with hereditary spherocytosis
Have a MCHC >36 g/dL |
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Term
|
Definition
Measure of the size variability of RBCs
Anisocytosis
Common in many types of anemia
An increased RDW may precede an abnormality in Hb or MCV
Microcytosis
Normocytosis
Macrocytosis |
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Term
| Microcytosis (Normal RDW) |
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Definition
Thalassemia Minor
Anemia of Chronic Disease |
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Term
|
Definition
Iron Deficendy
Hemoglobin H disease
Some Anemic of Chronic Disease
Some Thalassemia Minor
Fragmentation Hemolysis |
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Term
| Normocytosis (Normal RDW) |
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Definition
Anemia of Chronic Disease
Hereditary Spherocytosis
Some hemoglobinopathy
Acute bleeding |
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Term
|
Definition
Early or partially treated Fe or vitamin deficiency
SCA |
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Term
| Macrocytosis (Normal RDW) |
|
Definition
Aplastic Anemia
Some Myelodysplasias |
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Term
|
Definition
Vit B12 Deficiency
Folate deficiency
Autoimmune Hemolytic Anemia
Cold agglutinin disease
Liver or Thyroid disease
Alcohol |
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Term
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Definition
Should be examined when CBC is abnormal(get a manual dip)
May reveal clues to the etiology of the anemia
Reveals
Anisocytosis – variation of cell size
Poikilocytosis – variation of cell shape |
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Term
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Definition
| RBCs that are larger than normal RBCs and appear polychromatic, they are immature RBCs produced in response to an anemic state |
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Term
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Definition
| Grayish-blue color of the cytoplasm in reticulocytes caused by ribosomes |
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Term
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Definition
| a cell organelle made of ribosomal RNA and protein |
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