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chp 3 ap
chp 3 ap
148
Biology
Undergraduate 1
09/10/2010

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Term
Cell Theory
Definition

 

The cell is the smallest structural and functional living unit
functions depend on individual and collective cell functions
activities of cells are dictated by their specific subcellular structures
 
Continuity of life has a cellular basis
Term
Plasma Membrane
Definition

(selectively permeable/ decides what can go in and what cannot) 

Bimolecular layer of lipids and proteins in a constantly changing fluid mosaic
Separates  (ICF) from  (ECF)
(insterstial fluid/ between cells)
Term

fluid mosaic model

 

constantly changing

Definition
[image]
Term
lipid bilayer
Definition

forms the basic fabric of the membrane

75% phospholipids

 

5% glycolipid

20% cholesterol

Term
hydrophilic
Definition

each lollipop shaped phosphate molecule has a

charged polar head that is

Term
Fatty acid chains
Definition

phospholipid molecule has a nonpolar tail w/ no chage made up of __________

line up @ the center of the membrane

Term
 Cell
Definition

 

Plasma membrane—flexible outer boundary
Cytoplasm—intracellular fluid containing organelles
Nucleus—control center
Term
Lipid Rafts
Definition

a raft that sits on top of a cell w/ lil proteins sittin on it. foundation for cellular things to be sitting on

 

~ 20% of the outer membrane surface
Contain phospholipids, sphingolipids, and cholesterol
May function as stable platforms for cell-signaling molecules
Term

 

Integral proteins
Definition

go all the way across the bilipid membrane. stick all the way through the membrane 

 

Firmly inserted into the membrane (most are transmembrane)
Functions:
Transport proteins (channels and carriers), enzymes, or receptors
Term

 

Peripheral proteins
Definition

 

Loosely attached to integral proteins
Functions:
Enzymes, motor proteins, cell-to-cell links, provide support on intracellular surface, and form part of glycocalyx
Term
glycocalyx
Definition

(sugar covering)

part sugar part protein (tells self from nonself) (fits in receptor)

Term

membrane junctions

 

Tight junction

Definition

 

Impermeable junctions that encircle the cell

 prevent molecules from passing through the intercellular space

Term

membrane junctions

 

Desmosome

Definition

 strengthen hold between two cells

 

skin cells 

 

: Anchoring junctions scattered along the sides of cells

Term

membrane junctions

 

Gap junction

Definition

a nexus that allows chemical substances to pass between cells

 

 

channel for communicating between cells

 

Communicating junctions allow ions and small molecules to pass from one cell to the next for intercellular communication

Term
how do the phospholipid bilayer help seperate the IFC from the EFC?
Definition
phospholipid bilayer is made of lipids. the ifc and efc is made of water and the phospholipid bilayer help seperate water
Term
what is the importance of the glycocalyx
Definition
cell to cell recognition
Term
what kind of membrane juctrions would you find between heart and nerve cells
Definition
desmosomes and gap junctions
Term
what kind of junctions would be found between skin cells
Definition
desmosomes
Term
what kind of junctions would u find between stomach cells
Definition
tight juctions
Term

membrane transport (occurs only in living systems)

 

passive transport

Definition
 
No cellular energy (ATP) required
Substance moves down its concentration gradient
high to low
Term

 

What determines whether or not a substance can passively permeate a membrane?
Definition

 

1.Lipid solubility of substance
2.Channels of appropriate size
3.Carrier proteins
Term
Facilitated Diffusion
Definition
a type of passive transport in which transported substance either binds to a protien carrier in the membrane and is ferried across or moves through water filled protein
Term
diffusion
Definition
a type of passive transport in which molecules move from areas of higher concentration to lower concentration down or along its concentration gradient
Term
osmosis
Definition

the movement of solvent (water) across a selectively permeable membrane

 

Term
Osmolarity:
Definition
The measure of total concentration of solute particles
Term

 

Isotonic
Definition

 

solutions with same nonpenetrating solute concentration
no net water loss or gain, cell shape remains same
Term

 

Hypertonic
Definition

 

solutions with greater nonpenetrating solute concentration than cytosol
cells lose water and shrink/crenate
change in cell volume disrupts cell function
Term

 

Hypotonic
Definition

 

solutions with lesser nonpenetrating solute concentration than cytosol (ex-distilled water)
cells take in water cells plump/burst/lyse
change in cell volume disrupts cell function
Term
Active Transport
Definition

 

Requires carrier proteins (solute pumps)
Moves solutes against a concentration gradient
requires ATP
Term
Sodium-potassium pump (Na+-K+ ATPase)
Definition

solute pumps

moves solutes most importantly ions uphill against its concentration gradient

 

Located in all plasma membranes
Maintains electrochemical gradients essential for functions of muscle and nerve tissues
Term
Exocytosis
Definition

vescular transport process  that eject substances from the cells interior  into the extracellular fluid

 

use of ATP

 

ex: Hormone secretion

Neurotransmitter release
Mucus secretion
Term
Endocytosis
Definition

transport into cell

 

moves substances from the cells exterior to the cell interior

Term
Transcytosis
Definition

 

transport into, across, and then out of cell
Term
what is the energy source for all types of diffusion
Definition
 is driven by the kinetic energy of the molecules
Term
phagocytosis
Definition

cell eating

use ATP

cell engulfs some large or solid material

 

 

pseudopods engulf solids and bring them into cell’s interior
Term
pinocytosis
Definition

cell drinking

use ATP

 

 

plasma membrane infolds, bringing extracellular fluid and solutes into interior of the cell
Nutrient absorption in the small intestine
Term
 how are cavolae n clathrin coated pits similar
Definition
 capture specific molecules (flic acid, tetanus toxin) from the extra cellular fluid in coated vesicles and participates in some forms of transcytosis
Term
a cell placed in a hypotonic solution will
Definition
swell/ lyse
Term
isotonic solution
Definition

the cell will stay the same

will try to reach dynamic equilibrium

Term

Membrane Potential 

 

Definition

Separation of oppositely charged particles (ions) across a membrane

 

 

(voltage across the membrane)

Term

membrane potential

 

electrochemical gradient

Definition
the combined difference in concentration and charge influences the distrubution and direction of diffused ions
Term
cell adhesion molecules (CAM)
Definition

hold glycoproteins together 

 assist in movement of cells pass each other

assist in build up or break down of membrane junctions

embryonic and wound repair

Term
 Membrane Receptors
Definition

huge diverse group of intergral proteins and glycoproteins that serve as binding sites.

 

receives contact and chemical sigmaling

 

 

Term
G protein
Definition

act as a relay or middleman to activate or inactivate a membrane bound enzyme or ion channel

 

linked receptors inside helping to convey a message

Term
ligands
Definition

signaling chemicals that bind specifically to plasma membrane receptors

 

never enters/primary messenger

Term
second messenger
Definition

one or 2 intracellular chemical signals that are generated and connect plasma membrane events to the internal metabolic machinery of the cell

 

Term
resting membrane potential
Definition

diffusion of ions, mainly the diffusion of K+ from the cell throughh leakage channels establishes the

 

 

positive on the outside and negative on the inside

Term
what are the relative inside and outside charges of a cell @ rest? which ions are responsible?
Definition

the inside is negative relative to its outside

 

inside -K+

outside +NA+

Term

ligand gated channels are opened or closed in response to the binding of a chemical messenger such as a neurotransmitter

 

a voltage gated channel open and close depending on membrane potential

Definition
what is the difference between a voltage gated channel and a lingand gated channel?
Term
why do protein based hormones use second messengers while lipid based hormones do not?
Definition

because anything w/ a charge needs a secondary

messenger system

anything w/out a charge can go straight in

Term
cytoplasm
Definition

 

Located between plasma membrane and nucleus
consist of 3 parts: cytosol, organelles and inclusions
Term
membranous cytoplasmic organelles
Definition

mitochondria

peroxisomes

lysosomes

endoplasmic reticulum

golgi apparatus

Term
nonmemebranus cytoplasmic organells
Definition

 

Cytoskeleton
Centrioles
Ribosomes
Term
“What is the equation for cellular   respiration?”
Definition

C6H12O6 + 6O2 → 6H2O + 6CO2 + 30(net) ATP

Term

 

What are the three steps of   cellular respiration?”

Definition
Glycolysis, krebs cycle and Electron transport system
Term
Mitochondria
Definition

 all mitochondria comes from the egg (mother cell)

Double-membrane structure with shelflike cristae
Provide most of cell’s ATP via aerobic cellular respiration
Contain their own DNA and RNA
space is called matrix
Term
Ribosomes
Definition

 

Granules containing protein and rRNA
protein synthesis
Term
Free ribosomes
Definition

synthesize soluble proteins

float freely in the cytoplasm

imported into the mitchondria as well as some other organelles

Term
Membrane-bound ribosomes (on rough ER)
Definition
synthesize proteins to be incorporated into membranes or exported from the cell
Term
Rough ER
Definition

 

External surface studded with ribosomes
Manufactures all secreted proteins
Synthesizes membrane integral proteins and phospholipids
Term
Smooth ER
Definition

 

Tubules arranged in a looping network
Enzyme (integral protein) functions:
In the liver—lipid and cholesterol metabolism, breakdown of glycogen, and, along with kidneys, detoxification of drugs, pesticides, and carcinogens
Synthesis of steroid-based hormones
In intestinal cells—absorption, synthesis, and transport of fats
In skeletal and cardiac muscle—storage and release of calcium
Term
Golgi Apparatus
Definition

 

Stacked and flattened membranous sacs
Modifies, concentrates, and packages proteins and lipids

Transport vessels from ER fuse with convex cis face of

Term
vesicles
Definition

 

contains proteins destained for export pinch off from the transface which migrates tot the plasma membrane and discharge the contents from the cell
Term
Lysosomes
Definition

 

Spherical membranous bags containing digestive enzymes (acid hydrolases)
Digest ingested bacteria, viruses, and toxins
Degrade nonfunctional organelles
Break down and release glycogen
Break down bone to release Ca2+
Destroy cells in injured or nonuseful tissue (autolysis)
Term
Peroxisomes
Definition

 

Membranous sacs containing powerful oxidases and catalases
Detoxify harmful or toxic substances like hydrogen peroxide H2O2-> H2O + O ( free radical)
Neutralize dangerous free radicals (highly reactive chemicals with unpaired electrons)
Term
Cytoskeleton
Definition

acts as cells bones muscles and ligaments by supporting cellular structure and providing the machinery to provide various cell movements

 

Elaborate series of rods throughout cytosol
Microtubules
Microfilaments
Intermediate filaments
Term
Centrosome
Definition

 

: (“Center body”) near nucleus
Generates microtubules; organizes mitotic spindle
Contains centrioles:
Term
 centrioles
Definition

Small tube formed by microtubules (nine sets of triplets

generates microtubles and organizes the mitotic spindle in cell division

Term
Cilia and flagella
Definition

 

Whiplike, motile extensions on surfaces of certain cells

Contain microtubules and motor molecules

Term
Cilia
Definition
hair like projections that moves tuff across a cell like mucus in the trachea. air flowing in and out of the trachea is passive
Term
flagella
Definition
propel whole cells (tail of sperm)
Term
motor proteins
Definition

protein complexes that function in motility

(movement of organelles and contraction)

 

 powered by ATP

Term

 

Microvilli
Definition

 

Fingerlike extensions of plasma membrane
Increase surface area for absorption (so u can digest food)
Core of actin filaments for stiffening
Term
Nucleus
Definition

control center of the cell 

Genetic library with blueprints for nearly all cellular proteins
Responds to signals and dictates kinds and amounts of proteins to be synthesized
Term
nucleolus
Definition
makes ribosomes
Term
Chromatin
Definition

 

Threadlike strands of DNA (30%), histone proteins (60%), and RNA (10%)
Arranged in fundamental units called nucleosomes
Condense into barlike bodies called chromosomes when the cell starts to divide
Term
dna replication
Definition

process that occurs b4 cell division. it ensures all daughter cells have identical genes

 

 

End result: two DNA molecules formed from the original
 
This process is called semiconservative replication
Term

 

“Which cells are associated with G0?”

Definition
heart cells, brain cells and nerve cells
Term

 

Mitotic (M) phase of the cell cycle
Definition

 

Essential for body growth and tissue repair
Does not occur in most mature cells of nervous tissue, skeletal muscle, and cardiac muscle
Term
Cytokinesis
Definition
division of cytoplasm by cleavage furrow
Term
what is the 1st step of protein synthesis
Definition
transcription
Term
where does transcription take place
Definition
it takes place in the nucleus
Term
what is the 2nd step of protein synthesis
Definition
translation
Term
where does translation take place
Definition
it takes place outside of nucleus on the ribosomes
Term

what is a protease

 

ex: proteasomes

Definition
enzyme that breaks down proteins
Term

protein degredation

 

ubiquitin proteins

Definition

 

 used to marked damaged proteins to be degraded

Term
cell differentiation
Definition

 

Development of specific and distinctive features in cells
helps determine what type of cell its gonna be
Term
apoptosis
Definition

 

Elimination of excess, injured, or aged cells occurs through programmed rapid cell death _____________) followed by phagocytosis
Term
Anaplasia
Definition

abnormal cell structure; cancer cells different from parent cell

abnormalities in cell structure and loss of differentation

Term
Dysplasia
Definition

 

change in cell shape, size, or arrangement due  to  chronic irritation or inflammation

Term
hyperplasia
Definition
increase in size of tissue due to increase in cell number
Term
hypertrophy
Definition
increase in size of an organ or tissue due to increase in cell size
Term

 

  Telomeres

Definition
(strings of nucleotides on the ends of chromosomes) may determine the number of times a cell can divide
Term
chomosomes
Definition
DNA coiled
Term
what is the importance of ubiquitin in the life of a cell
Definition
because it helps get rid of damaged or unneeded proteins
Term
base
Definition

must end w/ an OH to be a

NaOH, Mg(OH),

except: NH3, HCO3

C2 OH and C2H3OH arent ____ causes start w/ carbon

 

grabs protons H+

Term
acid
Definition

if it stars w/ an H+

releases H+ to counter the OH-

Term
acidosis
Definition
under 7.35
Term
alkadosis
Definition
over 7.45
Term
respitory, cardiovascular and urinary system
Definition
what 3 body systems as part of their function to keep up acid base balance
Term
buffer system in blood
Definition

H2CO3 ----> H+ + HCO3-

 starts w/ carbonic acid           ends w/ a base                                   

Term
neautralization reaction
Definition
HCI + NaOH ------------> NaCl + H-OH
Term
strong acid/base
Definition
disassociate quickly so release many H+ or OH that will hurt you
Term
ATP has
Definition

potential and chemical energy

 

the only other kind of energy is positional energy

Term
chromatin
Definition
DNA uncoiled
Term
because the telemeres decide how many times a cell can divide
Definition
how are telemeres related to the condition "progeria" and dolly the cloned sheep?
Term
glycolipids
Definition
lipids w/ attached sugar groups
Term
transcription
Definition
involves the transfer of info from a DNAs base sequence to the complementary base sequence of an mRNA molecule
Term
translation
Definition
the language of nucleic acids (base sequence) is translated into the language of proteins (amino acid sequence)
Term
protein degredation
Definition
non functional organelle proteins are degraded by lysosomes
Term
methylation
Definition
turns genes of specific cells on or off
Term
simple diffusion
Definition
high to low non polar lipids- soluble diffuse straight through
Term
cell environment interactions
Definition
involves glycoproteins and proteins of glycocalyx
Term
what are some functions membrane proteins perform
Definition
transport, enzymatic activity, receptors for signal transduction, intercellular adhesion, cell to cell recognition 
Term
Substance (Vesicular) Trafficking
Definition
Transport from one area of cell or organelle to another.
Term
okasaki fragments
Definition
segments that comes from sagging strand in DNA replication
Term
DNA ligase
Definition
splices together short segments of discontinuous strand
Term
methylation
Definition
turns genes of specific cells on or off
Term
chemical -> endocytosis, exocytosis, and active transport
Definition
ATP is what kind of energy
Term
Aqueous channels types
Definition

 

Leakage channels
Always open
Gated channels
Controlled by chemical or electrical signals
Term
Helicase
Definition
untwists the double helix and exposes complementary chains
Term
replication fork
Definition

 

The Y-shaped site of replication
Term
complementary strand
Definition
Each nucleotide strand serves as a template for building a new
Term
DNA polymerase
Definition

 

only works in one direction
Continuous leading strand is synthesized
Term
DNA ligase
Definition
splices together short segments of discontinuous strand
Term
 (Okasaki fragments)
Definition

 

Discontinuous lagging strand is synthesized in segments
Term
“Go” signals
Definition

 

Critical volume of cell when area of membrane is inadequate for exchange

Chemicals (e.g., growth factors, hormones, cyclins, and cyclin-dependent kinases (Cdks

Term
Stop” signals:
Definition

 

Contact inhibition

Growth-inhibiting factors produced by repressor genes

Term
Genes
Definition
segments of DNA carrying instructions for a polypeptide chain
Term
Triplets
Definition

 

of nucleotide bases form the genetic library
Each specifies coding for an amino acid
Term

 

Messenger RNA (mRNA)
Definition
– carries the genetic information from DNA in the nucleus to the ribosomes in the cytoplasm
Term

 

Transfer RNAs (tRNAs)
Definition
bound to amino acids base pair with the codons of mRNA at the ribosome to begin the process of protein synthesis
Term

 

Ribosomal RNA (rRNA)
Definition
– a structural component of ribosomes
Term
rna polymerase
Definition
Enzyme that oversees synthesis of mRNA
Unwinds DNA template
Adds complementary RNA nucleotides on DNA template and joins them together
Stops when it reaches termination signal
mRNA pulls off the DNA template, is further processed by enzymes, and enters cytosol
Term
 Initiation
Definition

 

With the help of transcription factors, RNA polymerase binds to the promoter, pries apart the two DNA strands, and initiates mRNA synthesis at the start point on the template strand.

Term

 

Elongation

Definition

 

As the RNA polymerase moves along the template
strand, elongating the mRNA transcript one base at a time, it unwinds the DNA double helix before it and rewinds the double helix behind it.

Term

 

     Termination:

Definition

 

     mRNA synthesis ends when the termination signal
is reached. RNA polymerase and the completed mRNA transcript are released.

Term
RNA polymerase
Definition

 

DNA triplets are transcribed into mRNA codons by
Term
 ribosomes
Definition

 

Codons base pair with tRNA anticodons at the
Term
 (proteolysis)
Definition
Misfolded, damaged or unneeded proteins are marked for destruction
Term
proteasomes
Definition
The tagged proteins are then degraded by
Term
albumin
Definition
# 1 protein in your body
Term
acid
Definition
only proteins are disolved by
Term
autolysis
Definition
if a cell is dissolving their own functional organelle
Term
dehydration synthesis
Definition
when u want to synthesize something by removing water
Term
hydrolysis
Definition
when u want to break something down you want to add water
Term
glucose
Definition
sugar in your blood
Term
G1
Definition
biggest part of interphase where stuff grows and becomes what its gonna become
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