Term
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Definition
Direct Acting Muscarinic Agonist
Problem with using it as drug b/c it has short 1/2 life due to ACHe in plasma that breaks it down so it won't bind as much to receptor and it's way too non-specific b/c it binds at N and M receptors |
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Term
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Definition
Direct Acting Muscarinic Agonist
-more selective for urinary bladder and GI tract than BV and heart
therapeutic uses:
-post operative abdominal distension and urinary retention
-neurogenic atony of the urinary bladder with retention
NONOBSTRUCTIVE |
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Term
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Definition
Direct Acting Muscarinic Agonist
Therapeutic uses:
-Sjogren's syndrome (autoimmune disease that effects moisture producing glands (decreases salivary secretion)
-radiation induced dry mouth |
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Term
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Definition
Direct Acting Muscarinic Agonist
-newer drug for sjogren's syndrome
-works relatively selectively on salivary glands
-longer lasting salivation effect (4-6 hr) and fewer side effects than pilocarpine |
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Term
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Definition
Direct Acting Muscarinic Agonist
-not a drug
-present in Inocybe and clitocybe mushrooms
-mushroom poisioning |
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Term
| what's the MOA for direct acting muscarinic agonists? |
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Definition
| Bind to and activate muscarinic receptors |
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Term
| What are the effects of activating muscarinic receptors on the heart, BV, ciliary m., iris sphincter, GI tract, bladder? |
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Definition
| decrease HR, vasodilation (via NO), contraction/near vision, miosis, increase activity of gut, micturition |
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Term
| Would you use Bethanechol to treat BPH? |
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Definition
No
-not getting rid of the obstruction, just squeezing bladder so still can't urinate |
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Term
| what effect does muscarinic receptor activation have on glands? |
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Definition
| M3; coupled to Gq; increases Ca+2 and increases secretion |
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Term
| what symptoms might you expect to see in a person who has mushroom poisioning from Inocybe mushrooms? |
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Definition
| salivation, sweating, intestinal cramps/NVD (nausea, vomiting, diarrhea) |
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Term
| What are the adverse effects of direct acting muscarinic agonists? |
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Definition
stomach: increased gastric acid secretion-->aggravate ulcer
BV: dilation
Heart: bradycardia or reflex tachycardia
HYPOTENSION (decreased PVR b/c VD)
*baroreceptors can override the direct decrease in HR due to M receptor activation by the drug
lungs: increase secretion and bronchoconstriction so difficulty breathing/asthma attack
eye: spasm of accomodation; miosis |
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