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chloramphenicol, tetracyclines, macrolides, clindamycin
pharm ch. 44
27
Pharmacology
Graduate
10/31/2009

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Cards

Term
MOA of macrolides
Definition
inhibit 50S ribosome
Term
use of chloramphenicol
Definition
wide spectrum antimicrobial
Term
gray baby syndrome
Definition
toxicity of chloramphenicol
Term
drug interactions of chloramphenicol
Definition
phenytoin, tolbutamide, warfarin
Term
2 yo child ingesting pills for bacterial dysentery. he had vomiting, diarrhea w/ green stools, hypothermia, hypotension, and abdominal distention. what is this drug?
Definition
chloramphenicol
Term
the mechanism of antibacterial action of tetracyclines involves
Definition
block of binding of aminoacyl-tRNA to bacterial ribosomes
Term
24 yo F has syphilis and allergy to penicillin. a tetracycline will be used instead. which statement about the proposed drug treatment of this pt is accurate
Definition
for full effectiveness, tetracycline must be taken for 15 days
Term
clarithromycin and erythromycin have very similar spectra of antimicrobial activity. the major advantage of clarithromycin is that it
Definition
is more active against MAC
Term
a primary mechanism underlying the resistance of gram positive organisms to macrolide antibiotics is
Definition
methylation of binding sites on the 50S ribosomal subunit
Term
pt txed w/ spectinomycin for gonorrhea, did not take doxycycline comes in w/ mucopurulent cervicits. what is treatment?
Definition
treat her w/ single oral dose of azithromycin
Term
prophylaxis against bacterial endocarditis for someone who has prosthetic heart valves and allergic to penicillin. what is appropriate?
Definition
administer clindamycin orally 1 h before procedure
Term
management of CAP
Definition
doxycycline
Term
if pt is treated w/ erythromycin, she should
Definition
decrease her intake of caffeinated beverages
Term
pt should not be treated w/ telithromycin because the drug causes
Definition
hepatotoxicity
Term
in a pt w/ culture positive enterococcal baceremia who has failed to respond to vancomycin b/c of resistance the tx most likely to be effective is
Definition
linezolid
Term
which statement about doxycycline is accurate
Definition
it is used in lyme disease
Term
concerning streptogramins, which statement is accurate
Definition
they are used in the management of infections caused by multidrug-resistant streptococci
Term
which drug inhibits bacterial protein synthesis has a narrow spectrum of activity has been used in the management of abdominal abscess caused by b fragilis and may cause antibiotic associated colitis
Definition
clindamycin
Term
side effect of telithromycin
Definition
exacerbation of myasthenia gravis, hepatotoxicity
Term
undesirable effects of tetracyclines
Definition
photosensitivity and teeth staining
Term
DOC for Legionnaires' disease
Definition
Erythromycin
Term
Drug causes teeth discoloration
Definition
Tetracycline
Term
MOA of tetracycline
Definition
Decreases protein synthesis by inhibiting 30S ribosome
Term
Drug that causes gray baby syndrome and aplastic anemia
Definition
Chloramphenicol
Term
Drug notorious for causing pseudomembranous colitis
Definition
Clindamycin
Term
Oral antibiotic of choice for moderate inflammatory acne
Definition
Minocycline
Term
MOA of erythromycin
Definition
Inhibition of protein synthesis at the 50s subunit of ribosome
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