Term
| What are characteristics of hodgkin's disease? |
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Definition
Disorder of the lymph system
Arises from single lymph node or group of lymph nodes
Peak Occurrence
Occurs in teenagers |
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Term
| What are the main symptoms of hodgkin's lymphoma? |
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Definition
| Non-tender, rubbery, firm lymph node |
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Term
| What are symptoms seen in a person with aggressive Hodgkin's lymphoma? |
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Definition
| Fever, night sweats, puritis, weight loss |
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Term
| How is Hodgkin's lymphoma diagnosed? |
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Definition
| Redd-Sternberg cell is found in the bone marrow. A biopsy is used to stage the lymphoma. It spreads through the lymph system |
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Term
| What is the treatment for Hodgkin's Disease? |
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Definition
Chemotherapy- Four drugs (MOP) not for stage 1 & 2
Radiation- 95% Survival
Bone Marrow Transplant |
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Term
| What are the 3 subtypes of NHL? |
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Definition
1. Lymphoblastic
2. Undifferentiated
3. Large Cell |
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Term
| What is the 3rd most common cancer after Leukemia, & brain tumor? |
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Definition
| NHL; kids ages 7-11; 3xs more common in boys |
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Term
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Definition
| Malignant tumor of the lymphoreticular system- internal framework of the lymph; abnormal T cells, usually chromosomal |
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Term
| What are the two subtypes of undifferentiated NHL? |
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Definition
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Term
| What are differentiating factors of NHL & Hodgkins? |
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Definition
| NHL is acute onset with a rapid progression, Ages 7-11, bigger tumor that Lab pathologists will differentiate, it is not sensitive to radio therapy |
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Term
| Where is a common place for a NHL tumor to be? |
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Definition
| abdomen or mediastinum (trouble breathing in this location) |
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Term
| What are the clinical manifestations for NHL patients? |
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Definition
Fever
Weight loss
Enlarged, nodular lymph nodes |
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Term
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Definition
CBC, other labs
Bone marrow aspiration
Imaging studies
Tissue biopsy |
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Term
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Definition
Chemotherapy (can get tumor lysis syndrome that leads to renal failure)
Radiation not used commonly
Sugery
-tissue biopsy
-treat complications of tumor |
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Term
| What is Rhabdomyosarcoma? |
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Definition
| Tumor of the striated muscle with a finger like growth |
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Term
| Where are common sites for Rhabdomyosarcoma? |
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Definition
Muscles around the eyes
Muscles in the neck
Less common sites:
Abdomen
Genitourinary tract
Extremitites |
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Term
| What is the biomarker used to distinguish Rhabdomyosarcoma? |
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Definition
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Term
| What are clinical manifestations of Rhabdomyosarcoma? |
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Definition
Depends on tumor site
Eyes:
-Swelling
-Ptosis
-Visual disturbances |
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Term
| What is the Tx for Rhabdomyosarcoma? |
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Definition
1. Surgically remove tumor
2. Radiation is used to shrink the tumor prior to surgery or destroy tiny pieces after surgery
3. Chemo therapy |
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Term
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Definition
| Intraocular malignancy of the retina that can be bilateral or unilateral. The risk may be inherited. |
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Term
| What is the difference between inherited or new mutations in regards to retinoblastoma? |
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Definition
| Inherited is related to chromosome 13 (dominate) and leads to bilateral retinoblastoma (1/3 of pts). New mutations usually lead to unilateral retinoblastoma (2/3 of pts). |
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Term
| What is the may clinical manifestation for retinoblastoma? |
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Definition
| Leukokoria (white pupils) "cat's eye" reflex; it is hard to see in african americans |
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Term
| What is the tx for retinoblastoma? |
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Definition
Radiation (lower stages)
Chemo therapy
Enucleation of most involved eye if bilateral |
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Term
| At what age should you not do Radiation? |
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Definition
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Term
| What can result from retinoblastoma? |
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Definition
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Term
| What is the prognosis for retinoblastoma? |
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Definition
90% survival
B/c it is chromosomal there is a 30% chance it will come back as another cancer (osteosarcoma is common) |
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