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Chen - Translation and Genetic
Chen 2007 - Pro Trans
5
Medical
Professional
09/06/2007

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Cards

Term
Alpha Amanitine
Definition
amatoxin inhibits RNA pol II. Toxin mainly affects tissues with high protein synth (i.e. liver, brain, kids, pancreas, testes).
- 60% excreted to bile.
- fatty degeneration of hepatic parenchyma
- 1 gram of A.phalloides can yeild 2-4 times the lethal dose each day. Lethal dose is .1mg/kg.
Term
Ricin
Definition
from beans of castor plant, used in production of castor oil for brake & hydrolic fluid.
- 2 hemagglutinins and 2 toxins
- enters cell and acts on 60S ribosomal subunit preventing the binding of elongation factor 2
- INHIBITS PROTEIN SYNTHESIS AND LEADS TO CELL DEATH
Term
Diptheria Toxin
Definition
localized infection of mucous membranes or skin by nonmotile Gram positive rod Corynebacterium diptheriae and Corynebacterium ulcerans.
- disease or carrier state.
- usually upper resp tract infection
- also skin superinfections
- INHIBITS PROTEIN SYNTHESIS
Term
Trichothecene mycotoxins
Definition
- 40 cmps produved by common grain mold.
- INHIBIT PRO SYNTH BY BINDING TO RIBOSOMAL PEPTIDYLTRANSFERASE SITE
- concern of use as bio-weapon b/c of stability
- symptoms within 5-60 mins: inhalaition results in nasal itching, pain, sneezing, bloody runny nose, difficulty breathing, wheezing, cough and blood tinged saliva and sputum.
- ingestions cuases lack of apeptite, nausea, bomiting, stomcahc cramping, watery or bloody diarrhea.
- skin Sx include burning, reddened, tender skin, swelling, blistering, death of skin tiisues and sloughing of large areas of skin.
- eye exposure leads to pain, tearing, redness, blurred vision.
- other route exposure can lead to full body illness, weakness, fatigue, dizziness, lack of muscular coordination, irregular heartbeat, hyperthermia, extensive bleeding low BP
Term
The Genetic Code is:
punctuated or unpunctuated?
overlapping or nonoverlapping?
universal or not?
degenerate or not?
Definition
triplet, unpunctuated, nonoverlapping, unambiguous, degenerate, not quite universal.
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