Term
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Definition
nitrogen mustards, platinum analogs; MOA: cross linking DNA or base pairs, cell cycle non-spec. |
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Term
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Definition
cyclophosphamides, ifosfamide, melphalan, bendamustine, chlorambucil |
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Term
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Definition
cisplatin (platinol), carboplatin (paraplatin), oxaliplatin (eloxatin) |
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Term
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Definition
neuropathy; cold sensitivity, pharyngo-laryngeal dysthesia |
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Term
myelosupression of platinums |
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Definition
carboplatin= thrombocytopenia, cisplatin= anemia |
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Term
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Definition
nitrosureas, ethylenines, alkyl sulfonates, triazenes |
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Term
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Definition
type I and II toperisomerase inhibitors, |
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Term
topoisomerase II inhibitors (cell cycle non-specific) |
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Definition
anthracyclines; daunorubacin, doxorubaci, epirubacin, valrubicin |
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Term
topoisomerase II inhibitors (G-phase specific) |
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Definition
epidophyllotoxins; etoposide, teniposide |
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Term
myelosuppression-pancytopenia |
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Definition
topo I (irinotecan, topotecan) topo II (rubacins, etoposide and teniposide), folate antagonists, |
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Term
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Definition
drug to protect against cardiotoxicity and vesicant effects seen in rubacin administration; iron chelator that binds free radicals |
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Term
non-specific cell cycle inhibitors |
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Definition
nitrogen mustards, platinum agents, anthracyclines (rubacin/topo II inhib) |
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Term
S phase specific cell cycle inhibitors |
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Definition
topo I inhibitors (irinotecan, topotecan), purine analogues, pyrimidine analogs, folate analogues |
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Term
m phase specific cell cycle inhibitors |
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Definition
vinka alkaloids, taxanse, eribulin, exabepilone |
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Term
G phase specific cell cycle inhibitors |
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Definition
topo II ihibitors (etoposide, teniposide) and bleomycin |
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Term
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Definition
diarrhea, acute; use atropine, delayed; use loperamide |
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Term
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Definition
cladribine, clofarabine, fludabarine, pentostain, thoguanine, mercaptopurine (6-MP) |
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Term
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Definition
capecitabine, cytarbine, gencetabin, fluoruracil (5-FU) |
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Term
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Definition
methotrexate, pralatrexate, premetrexed |
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Term
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Definition
mucosal damage, nephrotoxicity, pancytopenia, |
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Term
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Definition
drug to decrease or prevent methotrexate toxicity |
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Term
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Definition
vincristine,vindesine, vinblastine, vinorelbine |
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Term
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Definition
mylosuppression (vinorelbine, vinblastine), vesicant, fatal if intrathecal admin, neurotoxicity, dose adjust for hepatic |
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Term
topoisomerase I inhibitors |
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Definition
canptotheicins; irinotecan, topotecan |
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Term
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Definition
paclitaxel, docetaxel, cabazitaxel |
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Term
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Definition
infusion HS caused by crephor; premedicate with H2, H1, steroid |
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