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Chemotherapy and cancer agents
therapy final
26
Pharmacology
Graduate
12/07/2012

Additional Pharmacology Flashcards

 


 

Cards

Term
alkylating agents
Definition
nitrogen mustards, platinum analogs; MOA: cross linking DNA or base pairs, cell cycle non-spec.
Term
nitrogen mustards
Definition
cyclophosphamides, ifosfamide, melphalan, bendamustine, chlorambucil
Term
platinum analogs
Definition
cisplatin (platinol), carboplatin (paraplatin), oxaliplatin (eloxatin)
Term
oxaliplatin ADRs
Definition
neuropathy; cold sensitivity, pharyngo-laryngeal dysthesia
Term
myelosupression of platinums
Definition
carboplatin= thrombocytopenia, cisplatin= anemia
Term
other alkylating agents
Definition
nitrosureas, ethylenines, alkyl sulfonates, triazenes
Term
enzyme inhibitors
Definition
type I and II toperisomerase inhibitors,
Term
topoisomerase II inhibitors (cell cycle non-specific)
Definition
anthracyclines; daunorubacin, doxorubaci, epirubacin, valrubicin
Term
topoisomerase II inhibitors (G-phase specific)
Definition
epidophyllotoxins; etoposide, teniposide
Term
myelosuppression-pancytopenia
Definition
topo I (irinotecan, topotecan) topo II (rubacins, etoposide and teniposide), folate antagonists,
Term
dexrazoxane
Definition
drug to protect against cardiotoxicity and vesicant effects seen in rubacin administration; iron chelator that binds free radicals
Term
non-specific cell cycle inhibitors
Definition
nitrogen mustards, platinum agents, anthracyclines (rubacin/topo II inhib)
Term
S phase specific cell cycle inhibitors
Definition
topo I inhibitors (irinotecan, topotecan), purine analogues, pyrimidine analogs, folate analogues
Term
m phase specific cell cycle inhibitors
Definition
vinka alkaloids, taxanse, eribulin, exabepilone
Term
G phase specific cell cycle inhibitors
Definition
topo II ihibitors (etoposide, teniposide) and bleomycin
Term
irinotecan ADRs (topo I)
Definition
diarrhea, acute; use atropine, delayed; use loperamide
Term
purine analogues
Definition
cladribine, clofarabine, fludabarine, pentostain, thoguanine, mercaptopurine (6-MP)
Term
pyrimidine analogues
Definition
capecitabine, cytarbine, gencetabin, fluoruracil (5-FU)
Term
folate antagonists
Definition
methotrexate, pralatrexate, premetrexed
Term
folate antag ADRs
Definition
mucosal damage, nephrotoxicity, pancytopenia,
Term
leukovorin
Definition
drug to decrease or prevent methotrexate toxicity
Term
vinca alkyloids
Definition
vincristine,vindesine, vinblastine, vinorelbine
Term
vinca alkyloids ADRs
Definition
mylosuppression (vinorelbine, vinblastine), vesicant, fatal if intrathecal admin, neurotoxicity, dose adjust for hepatic
Term
topoisomerase I inhibitors
Definition
canptotheicins; irinotecan, topotecan
Term
Taxanes
Definition
paclitaxel, docetaxel, cabazitaxel
Term
Taxane ADR
Definition
infusion HS caused by crephor; premedicate with H2, H1, steroid
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