Term
What does NRTI stand for? |
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Definition
Nucleoside reverse transcritpase inhibitors |
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Term
What does NTRTI stand for? |
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Definition
Nucleotide reverse transcriptase inhibitors |
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Term
What does NNRTI stand for? |
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Definition
Non-nucleoside reverse transcriptase inhibitor |
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Term
Are drug holidays recommended for HIV therapy? |
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Definition
No, they cause resistance |
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Term
What are 4 common black box warnings for reverse transcriptase inhibitors? |
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Definition
Hematological toxocity, myopathy, lactic acidosis and severe hepatomegaly |
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Term
Can you use stavudine with zidovudine? |
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Definition
No, zidovudine inhibits stavudine |
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Term
What is an adverse effect of protease inhibitors that is important to remember? |
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Definition
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Term
What is the name of the best tolerated NRTI? |
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Definition
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Term
Does Zidovudine or Abacavir have a higher incidence of hypersensitivity? |
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Definition
Abacavir has a higher incidence of hypersensitivity |
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Term
What HIV medication causes hyperpigmentation of soles and palms |
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Definition
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Term
NNRTIs commonly cause what adverse effect? |
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Definition
Rash-can be life threatening |
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Term
How can you avoid a rash associated with Nevirapine? |
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Definition
Avoid rash using low dose therapy initially |
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Term
How do protease inhibitors work? |
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Definition
Inhibits the HIV aspartic protease enzyme, blocking posttranslational processing of essential viral protein products |
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Term
Do protease inhibitors cause hypo or hyperglycemia? |
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Definition
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Term
What is the black box warning for Saquinavir? |
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Definition
Bioequivalence-cannot change drug manufacturers |
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Term
What protease inhibitor is the most potent CYP3A4 inhibitor? |
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Definition
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Term
What protease inhibitor contains propylene glycol, likely to cause a disulfram rxn when combined with alcohol? |
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Definition
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Term
What protease inhibitor, when combined with ritonavir, can cause intracranial hemorrhage? |
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Definition
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Term
What medication is a fusion inhibitor? |
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Definition
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Term
How do fusion inhibitors work? |
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Definition
Prevent virally induced conformational change in GP41 subunit permitting viral-host cell membrane fusion |
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Term
Maraviroc combined with thioridazine (antipsychotic) increases risk for what? |
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Definition
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Term
What is a big difference between Zidovudine and Didanosine? |
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Definition
Didanosine contains phenylalanine |
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