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Chemo 4
Slides 294-348
22
Pharmacology
Graduate
04/18/2010

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Cards

Term
What does NRTI stand for?
Definition
Nucleoside reverse transcritpase inhibitors
Term
What does NTRTI stand for?
Definition
Nucleotide reverse transcriptase inhibitors
Term
What does NNRTI stand for?
Definition
Non-nucleoside reverse transcriptase inhibitor
Term
Are drug holidays recommended for HIV therapy?
Definition
No, they cause resistance
Term
What are 4 common black box warnings for reverse transcriptase inhibitors?
Definition
Hematological toxocity, myopathy, lactic acidosis and severe hepatomegaly
Term
Can you use stavudine with zidovudine?
Definition
No, zidovudine inhibits stavudine
Term
What is an adverse effect of protease inhibitors that is important to remember?
Definition
Pancreatitis
Term
What is the name of the best tolerated NRTI?
Definition
Lamivudine
Term
Does Zidovudine or Abacavir have a higher incidence of hypersensitivity?
Definition
Abacavir has a higher incidence of hypersensitivity
Term
What HIV medication causes hyperpigmentation of soles and palms
Definition
Emtricitabine
Term
NNRTIs commonly cause what adverse effect?
Definition
Rash-can be life threatening
Term
How can you avoid a rash associated with Nevirapine?
Definition
Avoid rash using low dose therapy initially
Term
How do protease inhibitors work?
Definition
Inhibits the HIV aspartic protease enzyme, blocking posttranslational processing of essential viral protein products
Term
Do protease inhibitors cause hypo or hyperglycemia?
Definition
Hyperglycemia
Term
What is the black box warning for Saquinavir?
Definition
Bioequivalence-cannot change drug manufacturers
Term
What protease inhibitor is the most potent CYP3A4 inhibitor?
Definition
Ritonavir
Term
What protease inhibitor contains propylene glycol, likely to cause a disulfram rxn when combined with alcohol?
Definition
Amprenavir
Term
What protease inhibitor, when combined with ritonavir, can cause intracranial hemorrhage?
Definition
Tipranavir
Term
What medication is a fusion inhibitor?
Definition
Enfuvirtide
Term
How do fusion inhibitors work?
Definition
Prevent virally induced conformational change in GP41 subunit permitting viral-host cell membrane fusion
Term
Maraviroc combined with thioridazine (antipsychotic) increases risk for what?
Definition
QT prolongation
Term
What is a big difference between Zidovudine and Didanosine?
Definition
Didanosine contains phenylalanine
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