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Chemistry- Toxicology
test 4
31
Health Care
Undergraduate 4
10/27/2009

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Cards

Term
What kind of sample is used for most emergency toxicology screens?
Definition
urine
Term
What kind of sample is used for ethanol screening?
Definition
blood
Term
Symptom complexes that may give clues to an unknown poisoning
Definition
toxidromes
Term
What is the antidote for acetaminophen overdose?
Definition
N-acetylcysteine (Mucomyst)
Term
What is the antidote for digoxin overdose?
Definition
Fab fragments (Digibind)
Term
What is the antidote for opiate overdose?
Definition
naxalone (Narcan)
Term
Which is higher, serum alcohol or blood alcohol?
Definition
serum alcohol
Term
What is the ratio of serum alcohol to blood alcohol?
Definition
1.12-1.17
Term
What is the most common toxic substance encountered?
Definition
ethanol
Term
What is the best sample to use for ethanol testing?
Definition
gray top tube- whole blood
Term
What is the legally required method for measuring blood alcohol?
Definition
gas chromatography
Term
80 mg/dL blood alcohol would be what percent blood alcohol?
Definition
.08%
Term
Is there an antidote for ethanol?
Definition
No.
Term
What is the method for serum quantitation of acetaminophen?
Definition
immunoassay and HPLC
Term
What is the Rumack-Mathew nomogram used for?
Definition
acetaminophen overdose
Term
When is the optimal time to draw samples for suspected acetaminophen overdose?
Definition
4 hours after ingestion
Term
What is the method for serum quantitation of salicylates/ aspirin?
Definition
immunoassay
Term
What is the Done nomogram used for?
Definition
suspected overdose of salicylates (aspirin)
Term
Aggressive hemodialysis is recommended for serum concentrations of salicylates exceeding what level?
Definition
70 mg/dL for chronic overdose; 100 mg/dL for acute overdose
Term
Name the NIDA 5
Definition
cannabinoids; cocaine metabolite; amphetamines; opiates; PCP
Term
What does NIDA stand for?
Definition
National Institute of Drug Abuse
Term
What is the primary cocaine metabolite?
Definition
benzoylecognine
Term
antihistamines, Eldepryl, Didrex, and Vick's inhaler would cause false positives for what?
Definition
amphetamines
Term
What is the heroin metabolite?
Definition
6 monoacetyl morphine
Term
Which 2 NIDA 5 drugs are fat soluble?
Definition
cannabinoids and PCP
Term
Positive samples for workplace drug testing are stored in the lab freezer for how long?
Definition
1 year
Term
What are the creatinine and specific gravity requirements for reporting 'dilute specimen'?
Definition
creatinine less than 20 mg/dL; specific gravity between 1.0020 and 1.0030
Term
What are the creatinine and specific gravity requirements for 'substituted specimen'?
Definition
creatinine less than or equal to 2.0 mg/dL and specific gravity less than or equal to 1.0010 or greater than or equal to 1.0200
Term
If the nitrite concentration is greater than or equal to 500 ug/mL, what would you report?
Definition
adulterated specimen
Term
What are the pH ranges for reporting 'adulterated specimen'?
Definition
less than or equal to 3.0 or greater than or equal to 11.0
Term
What are the 3 criteria for adulterated specimen?
Definition
nitrites greater than or equal to 500 ug/mL; OR, pH 3.0 or less or 11.0 or greater; OR, presence of exogenous substance or endogenous substance higher than normal physiological concentration
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