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Chemistry Unit 6
Cpt. 16,17,18,19,20,21
128
Chemistry
Undergraduate 1
07/13/2012

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Term
aldose
Definition
a sugar that contains an aldehyde (carbonyl)group
Term
anomeric carbon
Definition
isomers of cyclic monosaccharides that differ from one another in the arrangements of bonds around the hemiacetal carbon
Term
carbohydrate
Definition
generally sugars and polymers of sugars; the primary source of energy for the cell
Term
cellulose
Definition
a polymer of B-D-glucose linked by B (1-->4) glycosidic bonds
Term
chair confirmation
Definition
the most energetically favorable conformation for a six-member cycloalkane, so called for itsresemblance of a lawn chair
Term
chiral carbon
Definition
a carbon atom bonded to four different atoms or groups of atoms
Term
disaccharide
Definition
a sugar composed of two monosaccarides joined through an oxygen an atom bridge
Term
Fischer projection
Definition
a two-dimensional drawing of a molecule which shows a chiral carbon at the intersection of two lines and horizontal lines representing bonds projecting out of a page and vertical lines representing bonds that project into a page
Term
fructose
Definition
a ketohexose that is also called levulose and fruit sugar; the sweetest of all sugars, the abundant in honey and friuts
Term
galactose
Definition
a aldohexose that is a component of lactose (milk sugar)
Term
glucose
Definition
an aldohexose, the most abundant monosaccharide; it is a component of many disaccharides, such as lactose and sucrose and a polysaccharides, such as cellulose, starch, and glycogen
Term
glyceraldehyde
Definition
an aldotriose that is the simplist carbohydrate; phosphorylated forms of glyceraldehyde are important intermediates in cellular metabolic reactions
Term
glycogen
Definition
a long branched polymer of glucose stored in the liver and muscles of animals; it consists of a linear backbone of a-D-glucose in a(1-->4) linage, with numerous short branches attached to the C-6 hydroxyl group by a (1-->6) linkage
Term
glycosidic bond
Definition
the bond between the hydroxyl group of the C-1 carbon of one sugar and a hydroxyl group of another sugar
Term
Haworth projection
Definition
a means od representing the orientation of substituent groups around a cyclic sugar molecule
Term
hemiacetal
Definition
the family of organic componds formed via the reaction of one molecule of alochol with the aldehyde in the presence of an acid catayst;
Term
hexose
Definition
a six carbon monosaccharide
Term
ketose
Definition
a sugar that contains a ketone (carbonyl) group
Term
lactose
Definition
a disaccharide composed of B-D-galactose and either A-or B-D-glucose in B(1-->4) glycosidic linkage; milk sugar
Term
maltose
Definition
a disaccharide composed of a-D-glucose and a second glucose molecule in a
(1-->4)GLYCOSIDIC LINKAGE
Term
monosaccharide
Definition
the simplist type of carbohydrate consisting of a single saccharide unit
Term
pentose
Definition
a five carbon monosaccaride
Term
polysaccharide
Definition
a large complex carbohydrate composed of long chains of monosaccharides
Term
ribose
Definition
a five carbon monosaccharide that is a component of RNA and many coenzymes
Term
saccharide
Definition
a sugar molecule
Term
steroisomers
Definition
a pair of molecules having the same structural formula and bonding pattern but differing in the arrangement of the atoms in space.
Term
sucrose
Definition
a disaccharide composed of a-D-glucose and B-D-fructose in (A1-->B2) glycosidic linkagel Table sugar
Term
cholesterol
Definition
a 27 carbon steroid ring structure thar serves as the precursor of the steriod hormones
Term
complex lipid
Definition
a lipid bonded to other types of molecules
Term
diglyceride
Definition
the product of esterification of glycerol at two positions
Term
emulsifying agent
Definition
A bipolar molecule that aids in the suspension of fats in the water
Term
essential fatty acid
Definition
the fatty acids linolenic and linolenic acids that must be supplied in the diet because the because they cannot by synthesized by the body
Term
esterfication
Definition
the formation of an ester in the reaction of a carboxylic acid and an alochol
Term
fatty acids
Definition
any member of the family of continous-chain carboxylic acids that generally contain four to twenty carbon atoms; the most concenterated source of energy used by the cell
Term
fluid mosaic model
Definition
the model of membrane structure that describes the fluid nature of the lipid bilayer and the presence of numerous protiens embedded within the membrane
Term
glyceride
Definition
a lipid that contains glycerol
Term
HDL (High density lipids)
Definition
a plasma lipoprotein that transports cholesterol from peripheral tissue to the liver
Term
hydrogenation
Definition
a reaction in which hydrogen (H2)is added to a double or triple bond
Term
lipid
Definition
member of a group of biological molecules of varying composition that are classified together on a basis of their solubility in nonpolar solvents
Term
LDL --Low density lipids
Definition
plasma lipoprotein that carries cholesterol to peripheral tissues and help to regulate cholesterol levels in those tissues
Term
monoglyceride
Definition
the product of the esterification of glycerol at one position
Term
phosohoglyceride
Definition
a molecule with fatty acids esterified at the C-1 and C-2 positions of glycerol and a phosphoryl group esterified at the C-3 position
Term
phospholipid
Definition
a lipid containing a phosphoryl group
Term
saponification
Definition
a reaction in which soap is produced; more generally, the hydrolysis of an ester by an aqueous base
Term
saturated fatty acid
Definition
a long chain monocarboxylic acid in which each carbon of the chain is bonded to the maximum number of hydrogen atoms
Term
sphingolipid
Definition
a phospholipid that is derived from the amino alocol spingosine rather from glycerol
Term
steroids
Definition
a lipid derivied from cholesterol and composed of one of the five-sided ring and three six-sided rings; the steriods include sex hormones and anti-inflammatory compounds
Term
triglyceride
Definition
a molecule composed of glycerol esterified to three fatty acids
Term
unsaturated fatty acid
Definition
A long-chain monocarboxylic acid having at least one carbon-to-carbon double bond
Term
wax
Definition
a collection of lipids that are generally considered to be esters of long chain alochols
Term
a-amino acid
Definition
the subunits of proteins composed od an a-carbon bonded to a carboxylate group, a pronated amino group, a hydrogen atom, and a variable R group
Term
coagulation
Definition
the process of which protiens in solution are denatured and aggregate with one another to produce a solid
Term
C-terminal amino acid
Definition
the amino acid in a peptide that has a free a-CO2- group; the last amino acid in a peptide
Term
denaturation
Definition
the process by which the organized structure of a protien is disrupted, in resulting in a completely disorganized, nonfunctional form of the protien
Term
enzyme
Definition
a protien that serves as a biological catalyst
Term
essential amino acid
Definition
an amino acid that cannot be synthesized by the body and must therore be supplied by the diet
Term
glycoprotien
Definition
a protien bonded to sugar groups
Term
a-helix
Definition
a right handed coiled secondary structure maintained by hydrogen bonds between the amide hydrogen of one amino acid and the carbonyl oxygen of an amino acid four residues away
Term
hemoglobin
Definition
a major protien component of red blood cells; the function of this red, iron-containing protein is transport of oxygen
Term
hydrophilic amino acid
Definition
"water loving" ; a polar or ionic amino acid that has a high affinity for water
Term
hydrophobic amino acid
Definition
"water fearing" a non polar amino acid that perfers contact with other non polar molecules over contact with water
Term
movement protien
Definition
a protien involved in any aspect of movement of an organization for instance actin and myosin in muscle tissue and flagellin that composes bacterial flagella
Term
N-terminal amino acid
Definition
the amino acid in a peptide that has a free a-N+H3 group; the first amino acid of a peptide
Term
peptide bond
Definition
the amide bond between 2 amino acids in a peptide chain
Term
b-pleated sheet
Definition
a common secondary structure of a peptide chain that resembles the pleats of an oriental fan
Term
primary structure
Definition
the linear sequence of amino acids in a protien chain determined by the genetic information of the gene for each protein
Term
protien
Definition
a macromolecule whose primary structure is a linear sequence of a-amino acids and whose final structure results from folding of the chain into a specific three-dimensional strucure; proteins serve as catalysts, structural components, and nutritional elements for the cell
Term
quarternary structure
Definition
aggregation of more than one folded peptide chain to yield a functional protein
Term
secondary structure
Definition
folding of the primary structure of a protein into an a-helix or a b-pleated sheet, folding is maintained by hydrogen bonds between the amide hydrogen and the carbonyl oxygen of the peptide bond
Term
tertiary structure
Definition
the globular; three -dimensional structure of a protien that results from the folding the regions of secondary structure this folding occurs spontaneously as a result of interactions of the side chains or R groups of the amino acids
Term
active site
Definition
the cleft in the surface of an ezyme that is the site of substrate binding
Term
allosteric enzyme
Definition
an ezyme that has an effector binding site and an active site; effector binding changes the shape of the active site, rendering it either active or inactive
Term
coenzyme
Definition
an organic group required by some enzymes; it generally serves as a donor or acceptor of electrons or a functional group in a reaction
Term
cofactor
Definition
an inorganic group, usually a metal ion, that must be bound to an apoenzyme to maintain the correct configeration of the active site
Term
competitive inhibitor
Definition
a structural analog, a molecule that has a structure very similar to the natural subtrate of an enzyme, competes with the natural subbstrate for binding to the enzyme active site and inhibits the reaction
Term
enzyme
Definition
a protien that serves as a biological catalyst
Term
enzyme-substrate complex
Definition
a molecular aggregate formed when the substrate binds to the active site of the enzyme
Term
induced fit model
Definition
the theory of enzyme-substrate binding that assumes that the enzyme is a flexible molecule and that both the substrate and the enzyme change their shapes to accommodate one another as the enzyme-substrate complex forms
Term
substrate
Definition
the reactant in a chemical reaction that binds to an enzyme active site and is converted to product
Term
adenine
Definition
Term
aminoacyl site (A site)
Definition
a pocket on the surface of ribsome that holds the aminoacyl tRNA during translation
Term
anticodon
Definition
a sequence of three ribonucleotides on a tRNA that are complementary to a codon on the mRNA; codon-anticodon binding results in delivery of the correct amino acid to the site of protein synthesis
Term
antiparallel strands
Definition
a term describibg the polarities of the two atrands of the DNA double helix; on one strand the sugar-phosphate backbone advances in 5'-->3' direction, on the opposite, complementary strand the sugar-phosphate backbone advances in 3'-->5'direction
Term
base pairs
Definition
a hydrogen-bonded pair of bases within the DNA double helix; the standard base pairs always involve purine and a pyrimidine ; in particular, adenine always base pairs with thymine and cytosine with guanine
Term
central dogma
Definition
statement of the directional transfer of the genetic information in cells: DNA-->RNA-->Protein
Term
chromosome
Definition
a piece of DNA that carries the genetic instructions, or genes, of an organism
Term
codon
Definition
a group of 3 ribonucleotides of the mRNA that specifies the addition of a specific amino acid onto the growing peptide chain
Term
complementary strand
Definition
the opposite strands of the double helix are hydrogen-bonded to one another such that adenine and thymine or guanine and cytosine are always paried
Term
cytosine
Definition
Term
deoxyribonucleic acid
Definition
DNA- the nucleic acid molecule that carries all the genetic information of an organism; the DNA molecule is a double helix composed of two strands, each of which is composed of phosphate groups, deoxyribose, and the nitrogenous base thymine, cytosine, adenine, and guanine
Term
double helix
Definition
the spiral staircase-like structure of the DNA molecule characterized by two sugar-phosphate backbones wound around the outside and nitrogenous bases extending to the center
Term
elongation
Definition
proteins that facilitate the elongation phase of translation
Term
guanine
Definition
Term
hydrogen bonds
Definition
the attractive force between a hydrogen atom convalently bonded to a small, highly electronegative atom and another atom containing an unshaped pair of electrons
Term
initiation
Definition
proteins that are required for formation of the translation initation complex, which is composed of the large and small ribosomal subunits, the mRNA, and the initiator tRNA, methionyl tRNA
Term
messenger RNA
Definition
an RNA species produced by transcription and that specifies the amino acid sequence for a protein
Term
nucleotide
Definition
a molecule composed of a nitrogenous base, a five-carbon sugar, and one, two or three phosphoryl groups
Term
peptide bond
Definition
the amide bond between two amino acids in a peptide chain
Term
peptidyl site (p site)
Definition
a pocket on the surface of the ribsome that holds the tRNA bound to the growing peptide chain
Term
phosphodiester bond
Definition
Term
protein synthesis
Definition
Term
purine
Definition
a family of nitrogenous bases that are components of DNA and RNA and consists of a six-sided ring fused to a five-sided ring; the common purines in nucleic acids are adenine and guanine
Term
pyrimidine
Definition
Term
release factor
Definition
a protein that binds to the termination codon in the empty A-site of the ribsome and causes the peptidyl transferanse to hydrolyze the bond between the peptide and the peptidyl tRNA
Term
replication
Definition
the region of a DNA molecule where DNA replication always begin
Term
ribonucleic acid
Definition
RNA- single stranded nuceic acid molecules that are composed of phosphoryl groups, ribose, and the nitrogenous bases uracil, cytosine, adenine, and guanine
Term
ribsome
Definition
a 5 carbon monosaccharide that is a component of RNA and many coenzymes
Term
termination codon
Definition
a triplet of ribonucleotides with no corresponding anticodon on a tRNA; as a result, translation will end, because there is no amino acid to transfer to the peptide chain
Term
thymine
Definition
Term
transcription
Definition
the synthesis RNA from a DNA template
Term
transfer RNA
Definition
small RNAs that bind to a specific amino acid at 3'end and mediate its addition at the appropriate site in a growing peptide chain; accomplished by recognition of the correct codon on the mRNA by the complementary anticodon on the tRNA
Term
translation
Definition
the synthesis of a protein from the genetic code carried on the mRNA
Term
uracil
Definition
Term
acetyl coenzyme A
Definition
molecule composed of coenzyme A and an acetyl group; the intermediate that provides acetyl groups for complete oxidation by aerobic respiration
Term
adenosine triphosphate (ATP)
Definition
a nucleotide composed of the purine adenine, the sugar ribose, and three phosphoryl groups; THE PRIMARY ENERGY STORAGE AND TRANSPORT MOLECULE USED BY THE CELLS IN CELLULAR METABOLISM
Term
aerobic respiration
Definition
the oxygen-requiring, degradation of food molecules and production of ATP
Term
anabolism
Definition
all of the cellular energy requiring bio synthetic pathways
Term
ATP synthase
Definition
the multiprotein complex within the mitochondrial membrane that uses the energy of the proton (H+) gradient to produce ATP
Term
catabolism
Definition
the degradation of fuel molecules and production of ATP for cellular functions
Term
citric acid cycle (also known as the Kreb Cycle)
Definition
the cuclic biochemical pathway that is the final stage of degradation of carbohydrates, fats, and amino acids. It results in the complete oxidation of acetyl groups derived from these dietary fuels
Term
coenzyme A
Definition
a molecule derived from ATP and the vitamin pantothenic acid; coenzyme A functions in the tansfer of acetyl groups in lipid and carbohydrate metabolism
Term
cristae
Definition
the folds of the inner membrane of the mitochondria
Term
electron transport system (ETS)
Definition
the series of electron transport protein embedded in the inner mitrochondrial membrane that accept high-energy electrons from NADH and FADH2 and transfer them in stepwise fashion to molecular oxygen
Term
glycolysis
Definition
the enymatic pathway that converts a glucose molecule into 2 molecules of pyruvate; this anaerobic process generates a net energy yield of two molecules of ATP and two molecules of NADH
Term
mitrochondria
Definition
the cellular power plants in which reactions of the citric acid cycle; the electron transport system, and the ATP synthase function to produce ATP
Term
nicotinamide adenine dinucleotide
Definition
a molecule synthesized from the vitamin niacin and the nucleotide ATP and that serves as a carrier of hydride anions; a coenzyme that is an oxidizing agent used in a variety of metabolic process
Term
nucleotide
Definition
a molecule composed of a nitrogenous base, a five carbon sugar, 1, 2, 3 phosphoryl groups
Term
oxidative phosphorylation
Definition
production of ATP using the energy of electrons harvested during biological oxidation-reduction reactions
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