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Chemistry Internship Study Questions Section 2
Endocrinology
65
Chemistry
Undergraduate 4
10/23/2015

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Term
What primary hormone RAISES plasma CALCIUM levels?
Definition
Parathyroid Hormone (PTH)
Term
What THYROID HORMONE acts to LOWER CALCIUM Levels?
Definition
Calcitonin
Term
What Hormone is DEFECTIVE in Diabetes Insipidus?
Definition
ADH
Term
What Endocrine gland regulates the secretion of ADH?
Definition
Posterior Pituitary
Term
What triggers the secretion of ADH?
Definition
Hyperosmolality (Dehydration, Increased Glucose)
Term
By what other name is ADH known by?
Definition
Vasopressin
Term
Indicate whether the lab results will be normal, increased, or decreased in Diabetes Insipidus:

Urine Volume
Definition
Increased
Term
Indicate whether the lab results will be normal, increased, or decreased in Diabetes Insipidus:

Urine Specific Gravity
Definition
Decreased
Term
Indicate whether the lab results will be normal, increased, or decreased in Diabetes Insipidus:

Urine Osmolality
Definition
Decreased
Term
Indicate whether the lab results will be normal, increased, or decreased in Diabetes Insipidus:

Serum Osmolality
Definition
Increased
Term
Explain the Normal Feedback Relationship between ACTH and Cortisol
Definition
As Cortisol DECREASES, ACTH INCREASES.
ACTH Increased levels trigger secretion of Cortisol.
When Cortisol gets High enough, ACTH Decreases
Term
Explain the Normal Expected variation of Cortisol between 8am and 8pm
Definition
Highest in the Morning.
Lowest in the Evening.
Term
How will Cushing's Disease affect this variation of Normal Cortisol between 8am and 8 pm?
Definition
No variation.
Levels will remain Increased regardless of time of day.
Term
What condition "turns on" the RAA system?
Definition
Low BP OR Low Blood Volume
Term
Aldosterone regulates the reabsorption of what analyte?
Definition
Sodium
Term
The reabsorption of Sodium by regulation from Aldosterone occurs in what area of the body?
Definition
Distal Renal Tubles
Term
What is the precursor substance of Steroid hormones?
Definition
Cholesterol
Term
Compare/Contrast Cushing's and Addison's based on the following expected results:
A
[image]
Definition
Increased
Term
Compare/Contrast Cushing's and Addison's based on the following expected results:
B
[image]
Definition
Increased
Term
Compare/Contrast Cushing's and Addison's based on the following expected results:
C
[image]
Definition
Increased
Term
Compare/Contrast Cushing's and Addison's based on the following expected results:
D
[image]
Definition
Decreased
Term
Compare/Contrast Cushing's and Addison's based on the following expected results:
E
[image]
Definition
Increased
Term
Compare/Contrast Cushing's and Addison's based on the following expected results:
F
[image]
Definition
Increased
Term
Compare/Contrast Cushing's and Addison's based on the following expected results:
G
[image]
Definition
Decreased
Term
Compare/Contrast Cushing's and Addison's based on the following expected results:
H
[image]
Definition
Decreased
Term
Compare/Contrast Cushing's and Addison's based on the following expected results:
I
[image]
Definition
Decreased
Term
Compare/Contrast Cushing's and Addison's based on the following expected results:
J
[image]
Definition
Increased
Term
Compare/Contrast Cushing's and Addison's based on the following expected results:
K
[image]
Definition
Decreased
Term
Compare/Contrast Cushing's and Addison's based on the following expected results:
L
[image]
Definition
Increased
Term
Name the 2 primary catecholamine hormones produced by the adrenal medulla
Definition
Epinephrine & Norepinephrine
Term
What is the FINAL METABOLITE of these hormones (Epinephrine & Norepinephrine) which can be measured in urine?
Definition
VMA
Term
What is the clinical significance of HIGH LEVELS of VMA?
Definition
May indicate severe adrenal disorder or pheochromocytoma
Term
What hormone levels are used in the evaluation of male infertility?
Definition
FSH, LH, Testosterone
Term
What is the primary function of FSH in a female?
Definition
Triggers secretion of estrogen
Term
What is the primary function of LH in a female?
Definition
Stimulates estrogen and progesterone secretion.
Triggers ovulation
Term
What is the primary function of Progesterone in a female?
Definition
Prepares uterus for implantation
Term
When does the following hormone peak during a normal menstrual cycle:
FSH
Definition
1st 1/2 of cycle
Term
When does the following hormone peak during a normal menstrual cycle:
LH
Definition
Just prior to ovulation
Term
When does the following hormone peak during a normal menstrual cycle:
Progesterone
Definition
2nd 1/2 of cycle
Term
The presence of what hormone is used to determine pregnancy?
Definition
HCG
Term
How frequently does the level of HCG normally double in the 1st 8 weeks?
Definition
Every 2 days
Term
In what condition would you see a lengthened doubling time of HCG?
Definition
Ectopic pregnancy
Term
List an abnormal condition associated with high levels of HCG in males
Definition
Testicular Cancer
Term
List an abnormal condition associated with high levels of HCG in nonpregnant females
Definition
Choriocarcinoma
Term
Name the 2 primary hormones secreted by the thyroid gland
Definition
T3 & T4
Term
What 2 lab tests are MOST Often used to assess thyroid function?
Definition
FT4 & TSH
Term
What is the MOST COMMON Cause of HYPERTHYROIDISM?
Definition
Grave's Disease
Term
List some of the MOST Common Symptoms associated with HYPERTHYROIDISM
Definition
Restlessness, Hyperactivity, Weight Loss despite large appetite, Skin/Vision changes
Term
What Common type of HYPOTHYROIDISM is associated with autoantibodies and plasma cell/lymphocyte infiltration of the Thyroid gland?
Definition
Hashimoto's
Term
List some of the MOST Common Symptoms associated with HYPOTHYROIDISM
Definition
Weight gain, Fatigue, Headaches, Memory Loss, Irritability, Cold Intolerance, Dry Skin, Brittle Hair
Term
What is the adverse consequence (condition) that results from CONGNITAL HYPOTHYROIDISM?
Definition
Cretinism
-Arrested mental & physical development
Term
Indicate whether the following test results would be Normal, Increased, or Decreased in the following conditions:
A
[image]
Definition
Normal
Term
Indicate whether the following test results would be Normal, Increased, or Decreased in the following conditions:
B
[image]
Definition
Increased
Term
Indicate whether the following test results would be Normal, Increased, or Decreased in the following conditions:
C
[image]
Definition
Increased
Term
Indicate whether the following test results would be Normal, Increased, or Decreased in the following conditions:
D
[image]
Definition
Decreased
Term
Indicate whether the following test results would be Normal, Increased, or Decreased in the following conditions:
E
[image]
Definition
Decreased
Term
Indicate whether the following test results would be Normal, Increased, or Decreased in the following conditions:
F
[image]
Definition
Normal
Term
Indicate whether the following test results would be Normal, Increased, or Decreased in the following conditions:
G
[image]
Definition
Decreased
Term
Indicate whether the following test results would be Normal, Increased, or Decreased in the following conditions:
H
[image]
Definition
Increased
Term
Indicate whether the following test results would be Normal, Increased, or Decreased in the following conditions:
I
[image]
Definition
Increased
Term
Indicate whether the following test results would be Normal, Increased, or Decreased in the following conditions:
J
[image]
Definition
Decreased
Term
Adequate removal of a Parathyroid tumor can be determined by performing Intraoperative PTH. How frequently are blood samples drawn during surgery?
Definition
Every 5-7 minutes
Term
How much should the PTH levels FALL to indicate adequate removal of the Parathyroid tumor?
Definition
Look for 50% drop from the highest level
Term
Prolactin is needed for what Normal body functions in the female?
Definition
Breast Development & Lactation
Term
What would be the purpose of performing a dilutional prolactin?
Definition
Avoid Prozone
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