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Chemistry Internship Study Questions Section 1
QC & Safety
55
Chemistry
Undergraduate 4
09/11/2015

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Term
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Accuracy
Definition
Agreement of results with the true value
Term
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Precision
Definition
Reproducibility
Term
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Mean
Definition
The average value in a set
Term
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Mode
Definition
Most common value in a set
Term
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2SD
Definition
95% Confidence Limits
Term
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CV
Definition
(SD x 100)/Mean
Term
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Standard
Definition
Substance whose exact concentrations are known
Term
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Control
Definition
Substance having a known "range" of values
Term
The mean for a particular control is 110 mg/dL. 1 SD = 5. What are the confidence limits for this control? (2SD)
Definition
100-120
Term
What is a delta check?
Definition
Comparison of a patient's results with their previous test results.
Term
What is the purpose for doing a delta check?
Definition
Helps detect sampling labeling errors, testing errors, and erroneous patient results.
Term
What is a systematic error?
Definition
Errors in the test system that affect all samples on the run.
Term
Give 2 examples of systemic error causes.
Definition
Incorrect calibration, bad reagents, malfunctioning dilutors or pipettes
Term
What is a random error?
Definition
Mistakes that occur without prediction or regularity, but do NOT affect all samples on a run
Term
How often can random errors be expected to occur?
Definition
May occur as frequently as 1:20 analysis.
Term
Give 2 examples of random error.
Definition
Temperature fluctuations, mislabeled specimens, clerical errors, carelessness
Term
What is a "trend"?
Definition
Gradual increased or decreased movement of control values in 6 or more consecutive runs.
Term
List 2 common causes of a "trend".
Definition
Deterioration of reagents, standards, or instrument performance.
Term
What is a "shift"?
Definition
When control results fall on either side of the mean on 6 or more consecutive control runs.
Term
List 2 common causes of a "shift".
Definition
Introduction of something new into the procedure such as new lot of reagents or a sudden malfunction of the instrument.
Term
What is the purpose of Westgard Rules?
Definition
A combination of decision criteria, or control rules, to decide whether an analytical run is in-control or out-of-control
Term
In regards to Westgard Rules, what does each of the following mean:

1-2S
Definition
1 Control is >2 SD (but less than 3 SD); "warning" rule
Term
In regards to Westgard Rules, what does each of the following mean:

1-3S
Definition
1 control is >3 SD; Due to random or systemic error
Term
In regards to Westgard Rules, what does each of the following mean:

2-2S
Definition
2 or more controls are >2 SD on the same day of testing or one control is >2 SD on 2 consecutive runs. Suggests Systemic Error
Term
In regards to Westgard Rules, can patient results be reported for the following Westgard Rule Errors:

1-2S
Definition
Accept Run
Term
In regards to Westgard Rules, can patient results be reported for the following Westgard Rule Errors:

1-3S
Definition
Reject Run
Term
In regards to Westgard Rules, can patient results be reported for the following Westgard Rule Errors:

2-2S
Definition
Reject Run
Term
Identify shifts, trends, and/or random errors in the following Levey-Jennings Chart below @ Day 10:
[image]
Definition
Random Error
Term
Identify shifts, trends, and/or random errors in the following Levey-Jennings Chart below @ Day 13-21:
[image]
Definition
Shift
Term
Identify shifts, trends, and/or random errors in the following Levey-Jennings Chart below @ Day 5-16:
[image]
Definition
Downward Trend
Term
Identify shifts, trends, and/or random errors in the following Levey-Jennings Chart below @ Day 18-27:
[image]
Definition
Upward Trend
Term
Identify the Westgard Rule in violation for this single control:
[image]
Definition
2-2S
Term
Identify the Westgard Rule in violation for this single control:
[image]
Definition
1-3S
Term
Looking at both controls each day, identify any Westgard Rule violations AND state whether the run can be accepted or must be rejected for Day 3:
Identify the Westgard Rule in violation for this single control:
[image]
Definition
1-2S
Accept
Term
Looking at both controls each day, identify any Westgard Rule violations AND state whether the run can be accepted or must be rejected for Day 9:
Identify the Westgard Rule in violation for this single control:
[image]
Definition
1-2S
Accept
Term
Looking at both controls each day, identify any Westgard Rule violations AND state whether the run can be accepted or must be rejected for Day 10:
Identify the Westgard Rule in violation for this single control:
[image]
Definition
2-2S
Reject
Term
Looking at both controls each day, identify any Westgard Rule violations AND state whether the run can be accepted or must be rejected for Day 20:
Identify the Westgard Rule in violation for this single control:
[image]
Definition
1-2S
Accept
Term
Looking at both controls each day, identify any Westgard Rule violations AND state whether the run can be accepted or must be rejected for Day 21:
Identify the Westgard Rule in violation for this single control:
[image]
Definition
2-2S
Reject
Term
Looking at both controls each day, identify any Westgard Rule violations AND state whether the run can be accepted or must be rejected for Day 6:
Identify the Westgard Rule in violation for this single control:
[image]
Definition
1-3S
Reject
Term
Looking at both controls each day, identify any Westgard Rule violations AND state whether the run can be accepted or must be rejected for Day 19:
Identify the Westgard Rule in violation for this single control:
[image]
Definition
1-2S
Accept
Term
Looking at both controls each day, identify any Westgard Rule violations AND state whether the run can be accepted or must be rejected for Day 20:
Identify the Westgard Rule in violation for this single control:
[image]
Definition
2-2S
Reject
Term
What does the MSDS stand for?
Definition
Material Safety Data Sheet
Term
Why is it important that the lab have a file of the MSDS?
Definition
Precautions & Treatment following exposure
Term
Label the Blue diamond in this National Fire Protection Agency Symbol:
[image]
Definition
Health
Term
Label the Red diamond in this National Fire Protection Agency Symbol:
[image]
Definition
Flammability
Term
Label the Yellow diamond in this National Fire Protection Agency Symbol:
[image]
Definition
Reactivity/Instability
Term
Label the White diamond in this National Fire Protection Agency Symbol:
[image]
Definition
Special Hazards
Term
With the National Fire Protection Agency Symbol, what does the number 0 represent?
Definition
No Hazard
Term
With the National Fire Protection Agency Symbol, what does the number 4 represent?
Definition
High Hazard
Term
What does the following symbol indicate:
[image]
Definition
Biohazard
Term
What does the following symbol indicate:
[image]
Definition
Explosive
Term
What does the following symbol indicate:
[image]
Definition
Flammable
Term
What does the following symbol indicate:
[image]
Definition
Toxic
Term
What does the following symbol indicate:
[image]
Definition
Corrosive
Term
What does the following symbol indicate:
[image]
Definition
Radiation
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