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Characteristics of an aerosol
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31
Biology
Undergraduate 3
02/05/2012

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Term
Bland aerosols
Definition
*Overcome humidity deficit
*aid in bronchial hygiene
*assist in sputum induction
Term
Aerosols to deliver medication
Definition
*do deliver bronchodilators
*to decrease upper airway inflammation
*to aid in bronchial hygiene
Term
Velocity
Definition
Distance traveled per unit time
Term
Capillary action
Definition
*liquid in small tube moves up against gravity
*involves both adhesive and surface tension forces
Term
Flow, velocity and cross sectional area
Definition
*principle underlines the application of nozzles our jets in fluid streams
*nozzles/jets are narrow passages designed to increase a fluids velocity
Term
Bernoulli effect definition
Definition
*when a fluid flows through a tube of inform diameter pressure decreases progressively over the tube length
*when fluid passes through a constriction the pressure drop is much greater
Term
Bernoulli effect: lateral pressure
Definition
*lateral pressure=a fluids pressure energy is the radial or outward force exerted by moving fluid
*moving fluids velocity and lateral pursue sum must be equal, therefore they vary inversely with each other
Term
Bernoulli effect more
Definition
As a flow of gas meets a restriction its lateral pressure decreases and forward velocity increase
Term
Fluid entrainment
Definition
*when fluid encounters a narrow passage, its velocity can increase greatly
*sometimes rise in velocity can be so great that pressure becoms negative-this neg pressure can pull another fluid into the primary flow system
Term
Bernoulli effect more
Definition
As a flow of gas meets a restriction its lateral pressure decreases and forward velocity increase
Term
Fluid entrainment
Definition
*when fluid encounters a narrow passage, its velocity can increase greatly
*sometimes rise in velocity can be so great that pressure becoms negative-this neg pressure can pull another fluid into the primary flow system
Term
Aerosol production via nebulizer
Definition
*decrease lateral wall pressure
*baffles
Term
Penetration
Definition
Refers to how far into the tracheal-bronchial tree aerosol particles can enter
Term
Deposition
Definition
Refers to where in the tracheo-bronchial tree the aerosol particles contact the bronchial walls
Term
Aerosol volume
Definition
product of particle size
Term
Aerosol output
Definition
weight or mass of the particles
Term
Density
Definition
weight or mass of aerosol per unit of gas leavin the nebulizer
Term
Aerosol meds penetrate and deposit sites in the lung through:
Definition
1.inertial impaction
2.gravitational sedimentation
3.diffusion onto lung surfaces
Term
Characteristics of theapeutic aerosols
Definition
size of particle
Physical characteristics
Amount of aerosol produced
Anatomy of airway
Ventilatory pattern
Term
Particle size
Definition
-heterodisperse: aerosol with wide range of particle size, found mostly in respiratory care
-monodisperse: aerosol that consists mainly of particles with similar size and density, usually needs special equipment, mainly found in lab research or industry
Term
MMAD
Definition
mass median aerodynamic diameter
50% smaller and 50% larger than mmad
Term
Penetration sizes
Definition
5-50 upper airway
2-5 lower airway
1-3 parenchyma, alveolar region
Less than 1 parenchyma
Term
Inertial impaction
Definition
need flow less than 1L/sec
Aerosols deposit when airstream changes direction
Inertia keeps particles going in a mores straigt diretion
Tendency to deposit at airway bifurcations
Term
Gravity or sedimentation
Definition
depends on density and particle size
Rate of sedimentation=dnsity x diameter^2
Term
Kinetic activity or diffusion
Definition
brownian movement

Smaller particles have more kinetic activity or brownian motion

Brownian motion is caused by collisions of gas molecules with aerosol particles
<1 um
Term
Temperature and humidity
Definition
particles can evaporate or increase in size
Aging
Term
Venitilatory pattern
Definition
inspiration flow = .5 L/sec is good (30L/min)
Slow respiratory rate and breath hold for 4-10sec
Term
Airway reactivity
Definition
Bronchospasms
cold aerosols
high density aerosols
medicated aerosols
Term
Drug reconcentration
Definition
higher concentration of dosage
Continuous aerosol therapy
Term
Over hydration
Definition
infants
Excessive saline solutions-hypernatremia
Term
Airway thermal injuries
Definition
heated aerosols
Monitor temperature
Set alarms
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