Term
Definition: Reduction in the number of microorganisms and viruses, particularly potential pathogens, on living tissue
Ex: Iodine; alcohol
Comments: Antiseptics are frequently disinfectants whose strength has been reduced to make them safe for living tissues. |
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Definition :Refers to an environment or procedure free of pathogenic contaminants
Ex: Preparation of surgical field; handwashing; flame sterilization of laboratory equipment
Comments: Scientists, laboratory technicians, and health care workers routinely follow standardized aseptic techniques. |
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Def: Suffixes indicating destruction of a type of microbe
Ex: Bactericide; fungicide; germicide; virucide
Comm: Germicides include ethylene oxide, propylene oxide, and aldehydes. |
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Def: Removal of microbes by mechanical means
Ex: Handwashing; alcohol swabbing at site of injection
Comm: Chemicals play a secondary role to the mechanical removal of microbes. |
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Def: Destruction of most microorganisms and viruses on nonliving tissue
Ex: Phenolics; alcohols; aldehydes; soaps
Comm: The term is used primarily in relation to pathogens. |
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Def: Use of heat to destroy pathogens and reduce the number of spoilage microorganisms in foods and beverages
Ex: Pasteurized milk and fruit juices
Comm: Heat treatment is brief to minimize alteration of taste and nutrients; microbes still remain and eventually cause spoilage |
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Def: Removal of pathogens from objects to meet public health standards
Ex: Washing tableware in scalding water in restaurants
Comm: Standards of sanitization vary among governmental jurisdictions. |
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Def: Suffixes indicating inhibition, but not complete destruction, of a type of microbe
Ex: Bacteriostatic; fungistatic; virustatic
Comm: Germistatic agents include some chemicals, refrigeration, and freezing. |
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Def: Destruction of all microorganisms and viruses in or on an object
Ex: Preparation of microbiological culture media and canned food
Comm: Typically achieved by steam under pressure, incineration, or ethylene oxide gas. |
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Term
Antibacterial Drugs That Inhibit Cell Wall Synthesis
Spectrum of action: Gram-positive (G+) bacteria
Route of administration: Topical
Adverse effects: Toxic to kidneys |
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Antibacterial Drugs That Inhibit Cell Wall Synthesis
Representative natural penicillins: Penicillin G, Penicillin V Representative semisynthetic penicillin: Ampicillin
Representative semisynthetic cephalosporins: Cefixime, Ceftriaxone Cefuroxime
Penicillium (penicillins) and Cephalosporium (cephalosporins); bind to and deactivate the enzyme that cross-links the NAM subunits of peptidoglycan |
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Antibacterial Drugs That Inhibit Cell Wall Synthesis
Blocks the gene for an enzyme that forms mycolic acid; analog of the vitamins nicotinamide and pyridoxine
Spectrum of action: Mycobacteria, including M. tuberculosis and M. leprae
Route of administration: Oral
Adverse effects: May be toxic to liver |
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Definition
Isoniazid (isonicotinic acid hydrazide, INH)
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Term
Antibacterial Drugs That Inhibit Cell Wall Synthesis
Directly interferes with the formation of alanine-alanine bridges between NAM subunits
Spectrum of action: Effective against most G+ bacteria but generally reserved for use against strains resistant to other drugs such as methicillin-resistant Staphylococcus aureus (MRSA)
Route of administration: IV
Adverse effects: Damage to ears and kidneys, allergic reactions
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Antibacterial Drugs That Inhibit Protein Synthesis
Gentamicin,Streptomycin, Tobramycin
Inhibit protein synthesis by irreversibly binding to the 30S subunit of prokaryotic ribosomes, this either causing the ribosome to mistranslate mRNA
Spectrum of action: Broad: effective against most G- bacteria
Route of administration: IV; do not traverse blood-brain barrier
Adverse effects: Toxic to kidneys and to auditory nerves, causing deafness
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Antibacterial Drugs That Inhibit Protein Synthesis
Spectrum of action: Broad, but rarely used except in treatment of typhoid fever
Route of administration: Oral; traverses blood-brain barrier
Adverse effects: In 1 of 24,000 patients, causes aplastic anemia, a potentially fatal condition in which blood cells fail to form; |
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Antibacterial Drugs That Inhibit Protein Synthesis
Azithromycin, Erythromycin
Spectrum of action: Effective against G+ and a few G- bacteria
Route of administration: Oral; do not traverse blood-brain barrier
Adverse effects: Nausea, mild gastrointestinal pain, vomiting; erythromycin increases risk of cardiac arrest |
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Antibacterial Drugs That Inhibit Protein Synthesis
Doxycycline, Tetracycline
Carry amino acids, from binding to ribosomes at the 30S subunit’s docking site
Spectrum of action: Most are broad: effective against many G+ and Gbacteria as well as against bacteria that lack cell walls, such as Mycoplasma
Adverse effects: Nausea, diarrhea, sensitivity to light; forms complexes with calcium, which stains developing teeth and adversely affects the strength and shape of bones |
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Antibacterial Drugs That Alter Cytoplasmic Membranes
Spectrum of action: Effective against G+ bacteria, particularly Pseudomonas, and some amoebae
Route of administration: Topical
Adverse effects: Toxic to kidneys |
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Antibacterial Drugs That Are Antimetabolites
Sulfadiazine, Sulfadoxine, Sulfanilamide
Synthetic drugs; first produced as a dye; analogs of PABA
Spectrum of action: Broad: effective against G+ and G- bacteria and some protozoa and fungi; however, resistance is widespread
Adverse effects: Rare: allergic reactions, anemia, jaundice, mental retardation of fetus if administered in last trimester of pregnancy
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Antibacterial Drugs That Are Antimetabolites
Blocks second metabolic step in the formation of folic acid from PABA; synergistic with sulfonamides
Spectrum of action: Broad: effective against G+ and G- bacteria and some protozoa and fungi; however, resistance is widespread
Adverse effects: Allergic reactions or liver damage in some patients |
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Antibacterial Drugs That Inhibit Nucleic Acid Synthesis
Representatives: Ciprofloxacin, Moxifloxacin, Ofloxacin
Synthetic agents that inhibit DNA gyrase, which is needed to correctly replicate bacterial DNA; penetrate cytoplasm of cells
Spectrum of action: Broad: G+ and G- bacteria are affected
Adverse effects: Tendonitis, tendon rupture |
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Antibacterial Drugs That Inhibit Nucleic Acid Synthesis
Representative: Metronidazole flagl
Spectrum of action: Obligate anaerobic bacteria
Adverse effect: hairy black tongue |
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Antibacterial Drugs That Inhibit Nucleic Acid Synthesis
Representatives: Rifampin
Bind to bacterial RNA polymerase, preventing transcription of RNA
Spectrum of action: Bacteriostatic against aerobic G+ bacteria; bactericidal against mycobacteria |
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Antiviral Drugs That Inhibit Viral Uncoating
Neutralizes acid environment within phagolysosomes that is necessary for viral uncoating
Spectrum of action: Influenza A virus
Adverse effects: Toxuc to central nervous system; results in nervousness, irritability, insomnia, and blurred vision |
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Antiviral Drugs That Inhibit Nucleic Acid Synthesis
Inhibits DNA and RNA synthesis
Spectrum of action: Viruses that code for kinase enzymes: herpes, Epstein- Barr, cytomegalovirus, varicella viruses, chickenpox |
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Antiviral Drugs That Inhibit Nucleic Acid Synthesis
Representatives: Azidothymidine (AZT
Inhibits DNA synthesis; viral reverse transcriptase more likely to incorporate these drugs; used in conjunction with protease inhibitor to treat HIV
Spectrum of action: HIV, hepatitis B virus
Adverse effects: Nausea, bone marrow toxicity |
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Antiviral Drugs That Inhibit Nucleic Acid Synthesis
Inhibits DNA and RNA synthesis; viral DNA polymerase more likely to incorporate the drugs
Spectrum of action: Respiratory syncytial, hepatitis C, influenza A, measles, some hemorrhagic fever viruses
Adverse effects: Perhaps harmful to developing fetus |
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Antiviral Drugs That Inhibit Viral Proteins
Which is unique to HIV, allowed the creation of drugs that block the active site
Spectrum of action: HIV
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Antifungal Drugs That Inhibit Cell Membranes
Representatives: Fluconazole, Itraconazole, Ketoconazole, Voriconazole
Antifungal action due to inhibition of synthesis of ergosterol
Spectrum of action: Fungi and protozoa |
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Antifungal Drugs That Inhibit Cell Membranes
Representatives: Amphotericin B, Nystatin
Associate with molecules of ergosterol, forming a pore through the fungal membrane
Spectrum of action: Fungi, some amoebae
Route of administration: Amphotericin B: IV; nystatin: topical
Adverse effects: Chills, vomiting, fever |
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Anthelmintic Drugs That Are Antimetabolites
Changes membrane permeability to calcium ions, which are required for muscular contraction
Spectrum of action: Cestodes, trematodes, tapeworm
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Antiprotozoan Drugs That Are Antimetabolites
Spectrum of action: Protozoa, Pneumocystis
Adverse effects: Possible rash, diarrhea, headache |
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Antiprotozoan Drugs That Inhibit DNA Synthesis
Representatives:Natural quinine, Semisynthetic quinines: Chloroquine Mefloquine, Primaquine
Derived from the bark of cinchona tree; inhibit metabolism of malaria parasites
Spectrum of action: Plasmodium
Adverse effects: Allergic reactions, visual disturbances |
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