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Chapter 8: Sleep & Biological Rhythms
Chapter 8: Sleep & Biological Rhythms
52
Physiology
Undergraduate 4
11/13/2011

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Term
Need to know
Definition
Slide 9, 10, 31, 39, 44/45, 58
Term
Electromyogram (EMG)
Definition
An electrical potential recorded from an electrode placed on a muscle
Term
Electrooculogram (EOG)
Definition
And electrical potential from the eyes; detects eye movements
Term
Alpha waves
Definition
Smooth; state of relaxation
Term
Beta waves
Definition
Irregular; state of arousal
Term
Stage 1 of sleep
Definition
Transition b/w wake and sleep
-Theta waves
Term
Stage 2 of sleep
Definition
10 minutes after stage 1
-Theta waves
-If awakened, you might not report that you were sleeping
Term
Sleep spindles
Definition
Short bursts of waves
-Occur during stages 1-4
-2-5 per minute
Term
K complexes
Definition
Sudden, sharp waves
-Occur during stage 2
-1 per minute OR after loud noises
Term
Stage 3 of sleep
Definition
15 minutes after Stage 2
-Delta waves (20-50% of the time)
Term
Stage 4 of sleep
Definition
20 minutes after stage 3
-Delta waves (>50% of the time)
-Deepest sleep
Term
REM stage of sleep
Definition
45 minutes after stage 4/90 minutes after beginning of sleep
-Theta and Beta waves
-Muscles paralyzed
-Report dreams
Term
Where in the brain is the biological clock?
Definition
Caudal brain stem
Term
Insomnia
Definition
Not a disease, but may be a symptom of pain, discomfort, or physical ailment
-Affects about 25% occasionally, 9% regularly
Term
What is one of the most important causes of insomnia?
Definition
Sleeping medication
Term
What are the three symptoms of narcolepsy?
Definition
An irresistible urge to sleep (sleep attack); cataplexy, sleep paralysis
Term
Sleep attack
Definition
A sudden urge to sleep
-sleep for 2-5 minutes and wake up refreshed
-usually happens under boring conditions
Term
Cataplexy
Definition
Complete paralysis that occurs during wakefulness
-fully conscious
-occurs during extreme emotional reactions
Term
Hypnagogic hallucinations
Definition
Occur during sleep paralysis
-dreaming while lying awake
Term
What is hypocretin's relationship to narcolepsy?
Definition
Destruction of these causes narcolepsy
Term
What is hypocretin also known as?
Definition
Orexin
Term
REM sleep behavior disorder
Definition
Person does not become paralyzed during REM sleep- acts out dreams
Term
Fatal familial insomnia
Definition
A fatal inherited disorder
-characterized by progressive insomnia
Term
Rebound phenomenon (define & example)
Definition
The increased frequency/intensity of a phenomenon after it has been temporarily suppressed
-after REM deprivation, there is an increase in REM sleep
Term
What are the 3 problems associated with slow-wave sleep?
Definition
-Bed wetting
-Sleepwalking
-Night terrors
Term
What are the effects of slow-wave sleep deprivation?
Definition
Cognitive abilities are affected
-trouble concentrating
-perceptual distortions
-hallucinations
Term
What effect does exercise have on slow-wave sleep, and what does this imply?
Definition
No relationship b/w exercise and the amount of slow-wave sleep
-implies that the primary function of slow-wave sleep is not to provide the body with rest
Term
What effect does mental activity have on sleep, and what does this imply?
Definition
If a part of the brain is stimulated during wakefulness, that part will show more delta waves during slow-wave sleep
-implies that slow-wave sleep provides the brain with rest
Term
Delta waves
Definition
Occur during slow-wave sleep
-the presence of delta waves in a part of the brain indicate that it is resting
Term
What percentage of sleep in newborns vs. adults is REM sleep, and what does this imply?
Definition
Newborns ~70%
Adults ~15%
-Implies that REM sleep is important for learning
Term
What are the 2 hypotheses for the function of REM sleep?
Definition
-Integrates the day's memories with existing memories
-Flushes useless memories
Term
Acetylcholine (ACh)
Definition
One of the most important NT involved in arousal
-produce activation and cortical desynchrony when stimulated
-highest activity during wakefulness and REM sleep
Term
Where in the brain are the two groups of ACh neurons located?
Definition
-Basal forebrain
-Pons (LDT, PPT)
Term
Norepinephrine (NEpi)
Definition
Catecholamine agonists that produce arousal and sleeplessness
-these effects are caused by the locus coeruleus
Term
Locus coeruleus (LC)
Definition
A group of noradrenergic cell bodies in the pons
-involved in arousal and vigilance
Term
Serotonin (5-HT)
Definition
Play a role in activating behavior
-mostly found in the raphe nuclei
Term
Histamine
Definition
An amino acid that is involved in the control of wakefulness/arousal
-active during wakefulness
-low during slow-wave/REM sleep
Term
Tuberomammillary nucleus
Definition
Contains histamine neurons involved in cortical activation and behavioral arousal
Term
Hypocretin
Definition
A peptide
-Produced by neurons whose cell bodies are in the hypothalamus
-excitatory, wakefulness-promoting effect
-active during wakefulness, inhibited during sleep
Term
Ventrolateral Preoptic Area (VLPA)
Definition
A group of GABA neurons that suppress alertness/behavioral arousal and promote slow-wave sleep
Term
PGO wave (pontine, geniculate, occipital)
Definition
Bursts of electrical activity starting in the pons, and going to the LGN and visual cortex
-in REM sleep
Term
Peribrachial area
Definition
Contains ACh neurons that are involved in the initiation of REM sleep
-located in the dorsolateral pons
Term
What three parts of the brain are involved in the initiation of REM sleep?
Definition
-Peribrachial area
-MPRF
-Magnocellular nucleus
Term
MPRF
Definition
Contains neurons involved in the initation of REM sleep
-activated by ACh neurons of the peribrachial area
Term
Magnocellular nucleus
Definition
Involved in the paralysis in REM sleep
-in the medulla
Term
Suprechiasmatic nucleus (SCN)
Definition
Contains biological clock that organizes many of the body's circadian rhythms
-located in the hypothalamus on top of the optic chiasm
Term
Melanopsin
Definition
A photopigment in the ganglion cells in the retina that projects info to the SCN
Term
Effects of lesions to the SCN (2)
Definition
-Eliminates circadian rhythm
-Sleep pattern disrupted, but not amount of sleep
Term
Zeitgeber
Definition
A stimulus (usually light) that resets the biological clock
Term
Effect of lesions to retina or optic nerve (remove zeitgebers)
Definition
-Circadian behaviors are "free-running", not entrained
Term
Pineal gland
Definition
Produces melatonin and plays a role in circadian/seasonal rhythms
-attached to the dorsal tectum
Term
Melatonin
Definition
Plays a role in circadian/seasonal rhythms
-secreted at night by the pineal gland
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