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Chapter 6: Exposure Assessment
Human Health Risk Assessment study cards Baylor University
11
Environmental Studies
Undergraduate 4
02/28/2013

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Term
characterization of chemical exposure problems
Definition
--process used to
1. establish the presence or absence of chemical hazards
2. delineate the nature and degree of the hazards
3. determine possible human health threats posed by the exposure or hazard situation
Term
important factors in exposure assessment
Definition
--routes of exposure
--durations
--nature and behavior of chemical substances

--used to estimate rates at which chemicals are absorbed by the potential human receptor given a specific scenario
Term
factors affecting human exposure to chemical hazards
Definition
--routes of exposures
--chemical translation from environmental concentration to absorbed concentration
--spatial and temporal issues (same location?, same time frame and duration?)
Term
intake
Definition
--the amount of chemical coming into contact with a receptor's visible exterior body or with the abstract/conceptual exchange boundaries
Term
dose
Definition
--amount of chemical absorbed by the body into the bloodstream
Term
chronic daily intake
Definition
--measures long-term exposures, is based on the number of events that are assumed to occur within an assumend lifetime for potential receptors
Term
subchronic daily intake
Definition
--projected receptor exposures over a short-term period (subchronic non-carcinogenic effects)
Term
bioaccessibility
Definition
--fraction of the chemical that desorbs from its matrix in the GI tract and therefore is available for absorption
Term
absorption
Definition
--describes the transfer of a chemical across a biological membrane into the blood circulation
Term
bioavailability
Definition
--fraction of a chemical that is taken up by the body's circulatory system relative to the amount that an organism is exposed to during an exposure scenario
Term
bioavailability of COC
Definition
--multiply the fraction of the chemical that is bioaccessible and the fraction that is absorbed
--bioaccessibility (typically a %)
--absorption factor (typically a % or can be turned into a %)
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