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Chapter 6C
Objectives
24
Physiology
Undergraduate 2
02/08/2011

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Term
Adrenergic
Definition
adrenaline (epinephrine, norepinephrine)
Term
Cholinergic
Definition
acetylcholine
Term
Dopaminergic
Definition
dopamine
Term
Serotinergic
Definition
serotonin
Term
How are transmitters released
Definition
Voltage gated calcium channels in axon terminal are open and calcium triggers exocytosis of neurotransmitters vesicles from their respective neurons
Term
How might the activity of a neurotransmitter be terminated
Definition
GABA firing acts as inhibitory by opening potassium or chloride and calcium channels are closed. Both presynaptic and postsynaptic inhibition.
Term
Subthreshold stimulus
Definition
stimulus capable of depolarizing membrane but not by enough to reach threshold
Term
Suprathreshold stimulus
Definition
stimulus that has more than enough depolarization to reach threshold
Term
Presynaptic autorecptors
Definition
Have sites for receptors to attach to which can limit the neurotransmitter being released
Term
Synapse
Definition
anatomically specialized junction between 2 neurons where electrical activity in one neuron influences excitability of second.
Term
Synpatic vesicle
Definition
cellular structure that holds and releases neurotransmitter at the synapse
Term
synaptic cleft
Definition
narrow extracellular space separating pre and post synaptic neurons at chemical synapses
Term
EPSP
Definition
excitatory postsynaptic potential: depolarizing graded potential in postsynaptic neuron in response to activation of excitatory synapse
Term
IPSP
Definition
inhibitory postsynaptic potential: hyperpolarizing graded potential that arises in postsynaptic neuron in response to activation of inhibitory synaptic endings upon it
Term
Molecular weight
Definition
Neurotransmitter- low. Neuromodulator-varies but tends to be high
Term
Duration of action
Definition
neurotrasmitter is msec to sec. neuromodulator is minutes to hrs
Term
Sources
Definition
Neurotransmitter is from firing of neuron. Neuromodulator is from neurons and other cells (paracrine)
Term
Effect on Target Cells
Definition
Neurotransmitter is EPSP, IPSP, or intraceullular biochemical reaction. Neuromodulator influences response of neurotransmitter via channels, qty/activity of 2nd messenger, amount of neurotransmitter.
Term
Temporal summation
Definition
one presynaptic neuron fires very rapidly, builds up
Term
Spatial summation
Definition
several neurons fire at same time
Term
Temporal and spatial summation
Definition
Necessary in order to produce a great enough stimulus to reach action potential
Term
Ester
Definition
acetylcholine
Term
norepinephrine
Definition
aromatic rings with alcohol and amine group.
Term
Epinephrine
Definition
aromatic rings with alcohol and amine group. Methyl group attached to the nitrogen.
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