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Chapter 5
micro chapter 5
34
Microbiology
Undergraduate 1
02/01/2011

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Term
metabolism
Definition
the sum of all chemical reactions
Term
catabolism
Definition
chemical reactions that result in the breakdown of more complex organic molecules into simpler substances
Term
anabolism
Definition
simpler substances are combined to form more complex molecules
Term
enzymes
Definition
proteins that are produced by living cells, that catalyze chemical reactions by lowering the activation energy. they operate at low temperatures and the names usually end in -ase
Term
holoenzymes
Definition
enzymes consisting of a protein portion and a non protein portion
Term
apoenzyme
Definition
the protein portion of a holenzyme
Term
cofactor
Definition
the non-protein portion of a holoenzyme. can be a metal ion or a complex organic molecules
Term
coenzyme
Definition
a specialized cofactor. it is a complex organic molecule (NAD+, NADP+, FMN, FAD, or coenzyme A)
Term
induced-fit model
Definition
when an enzyme and substrate combine, the substrate is transformed and then enzyme is recovered.
Term
denaturation
Definition
when enzymes are exposed to high temperatures and they subsequently lose their catalytic properties
Term
competitive inhibitors
Definition
compete with the normal substrate for the active site of the enzyme
Term
non-competetive inhibitors
Definition
act on the other parts of the apoenzyme or on the cofactor and decrease the enzyme's ability to combine with the normal substrate
Term
oxidation
Definition
the removal of one or more electrons from a substrate
Term
reduction
Definition
the gain of one or more electrons
Term
phosphorylation
Definition
when a phosphate is added to an ADP molecule to make it into ATP
Term
substrate-level phosphorylation
Definition
when a high energy phosphate from an intermediate catabolism is added to ADP
Term
oxidative phosphorylation (electron transport chain)
Definition
energy is released as electrons are passed to a series of electron acceptors and finally to O2 or another inorganic compound
Term
metabolic pathways
Definition
a series of enzymatically catalyzed chemical reactions that store energy in and release energy from organic molecules
Term
glycolysis
Definition
the most common pathway for the oxidation of glucose. pyruvic acid is the end product. 2 ATP and 2 NADH molecules are produced from one glucose molecule. there is an energy conserving stage and an energy consuming stage
Term
pentose-phosphate pathway
Definition
used to metabolize five-carbon sugars; one ATP and 12 NADH molecules are produced from one glucose molecule
Term
entner-doudoroff pathway
Definition
yields one ATP and two NADPH molecules from one glucose
Term
cellular respiration
Definition
during respiration, organic molecules are oxidized. energy is generated from the electron transport chain.
Term
aerobic respiration
Definition
O2 functions as the final acceptor. prokaryotes produce 38 ATP molecules from complete oxidation of one glucose molecule in glycolysis, the krebs cycle, and the e- transport chain. eukaryotes can only produce 36 ATP. it takes more energy to get NADH into the mitochondria
Term
anaerobic respiration
Definition
the final e- acceptor includes nitrate, sulfate and carbonate. the total ATP yield is less than aerobic because only part of the Krebs cycle operates under anaerobic conditions.
Term
the krebs cycle
Definition
decarboxylation of pyruvic acid produces one CO2 molecule and one acetyl group. This is the intermediate step between glycolysis and the krebs cycle. 2 C acetyl groups are oxidized in the krebs cycle. e- are picked up by NAD+ and FAD for the e- transport chain. produces 6 NADH, and 2 FADH2 and 2 ATP.
Term
electron transport chain
Definition
e- are brought to the e- transport chain by NADH. the e- transport chain consists of carriers that are in turn oxidized and reduced as electrons are passed down the chain.
Term
the chemiosmotic mechanism of ATP generation
Definition
protons being pumped across the membrane generate a proton motive force as e- move through a series of acceptors and carriers. energy produced from movement of the protons back across the membrane is used by ATP synthase to make ATP from ADP and phosphates. in eukaryotes, the ETC is located in the inner membrane of mitochindria, the plasma membrane in prokaryotes
Term
fermentation
Definition
releases energy from sugars by oxidation. O2 is not required. 2 ATP are produced by substrate level phosphorylation. the final e- acceptor is an organic molecule.
Term
lactic acid fermentation
Definition
pyruvic acid is reduced by NADH to produce lactic acid.
Term
alcohol fermentation
Definition
acetaldyyde is reduced by NADH to produce ethanol
Term
heterolactic fermenters
Definition
can use the pentose phosphate pathway to produce lactic acid and others
Term
homolactic fermentation
Definition
produces lactic acid only
Term
lipid and protein catabolism
Definition
lipases hydrolyze lipids into glycerol and fatty acids. catabolic products can be further broken down in glycolysis and the krebs cycle. before amino acids can be catabolized, they must be converted to various substances that enter the krebs cycle.
Term
amphibolic pathways
Definition
anabolic and catabolic reactions are integrated through a group of common intermediates
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