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- made up of keratinized stratified squamous epithelium |
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- produce the water insoluble protein keratin whichhardens structures - Approx. 90% of Epidermal cells |
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- produce melanin, a brown/black pigment which absorbs UVlight and is the primary skin pigment - Approx. 8% of Epidermal cells |
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- produced in the bone marrow - help provide immunity to the epidermis |
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- a single layer of cuboidal shaped cells - mitotically active |
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- 8 to 10 cell layers thick - cells start to flatten as they reach the upper part ofthis layer |
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- 3 to 5 cell layers thick - cells continue to flatten out - cells begin to die forming a water resistant barrier,i.e. keratinization |
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- only present on the finger tips, palms and soles of thefeet - 3 to 5 layers of cells |
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- 20 to 30 cell layers in thickness - flattened dead keratinocytes, no nuclei - outer layers are continually shed needing to bereplaced - Approx. 3/4 of the epidermal thickness |
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- mostly connective tissue containing collagen & elastinfibers, few cells - two regions (layers): |
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- superficial portion - Dermal Papillae = tiny projections into the epidermis whichincrease the surface area of the Stratum Basale - Meissner corpuscles (corpuscles of touch) = tactilereceptors located at the apex of Dermal Papillae - Epidermal Ridges = Dermatoglyphs = Finger prints assoc. with the underlying papillae |
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- deepest and largest portion - contains irregular C.T. |
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- composed of Adipose and Areolar C.T. - stores fat - contains vessels and nerves that supply the skin |
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- brown/black pigment produced from Melanocytes - made from amino acid Tyrosine (Tyrosinase) - disorders: Albinism, Vitiligo |
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- a yellow/orange pigment; not assoc. with jaundice - assoc. with vitamin A |
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- pink/red pigment - the oxygen carrying molecule in RBCs - assoc. with translucent skin (i.e. skin lacking melanin) |
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- covers most skin surfaces - columns of dead keratinized cells that are bonded together - protects the body from heat loss and UV light |
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= portion of the hair above the surface of the skin = portion of the hair below the surface = tissue that surrounds the root of the skin |
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- plates of tightly packed, keratinized epidermal cells |
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- secrete sebum, an oily substance that softens and lubricatesthe skin, water proofing, maintains hair follicles,contains antibacterial substances - associated with hair follicles, lips, pubic region - not found on palms and soles |
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Sudoriferous (Sweat) Glands |
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- release secretions onto the surface of the skin |
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- most common - produces watery sweat that contains ions and small organicmolecules - help regulate body temperature, eliminate wastes |
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- common to axilla and groin - watery secretion, more viscous than normal sweat, containsproteins and lipids - secondary sexual function |
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- when only the Epidermis is damaged - the cells surrounding the wound enlarge and migrate to fillthe gap created by the injury - mitosis in the Stratum Basale is stimulated, more cells arereproduced to make up for dead cells |
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migration ceases when the cells on bothsides of the wound come into contact |
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- clot forms over wound - local vasodilation, leukocytes (to fight infection) andfibroblasts (rebuild tissue) move into the damaged area |
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- scab forms - granulation (scar) tissue is laid down beneath the scab - vessels begin to regrow |
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- epithelial tissues begin to mature - collagen is laid down randomly |
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- the scab falls off after the epidermis is restored - circulation is restored - fibroblasts decrease in number |
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The process of scar tissue formation. Scar tissue isnot as healthy as the original tissue. |
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Uncontrolled fibrosis. Contact inhibition does not occurso the scar tissue does not stay with in the boundary ofthe wound. |
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- collagen and elastin fibers stiffen and lose elasticity - decreased activity of sweat and sebaceous glands - subcutaneous fat decreases |
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most common, arises from cells ofstratum basale, rarely metastasizes |
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- fairly rare but has high metastasis rate, cancer of the melanocyte |
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- skin type, amount of sun exposure, family history, age,immune status |
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- tissue damage caused by excessive heat, radioactivity, orchemicals that denature proteins in skin cell |
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- only the epidermis is damaged |
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- damage goes through the epidermis and into the dermis |
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