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Mech: Inhibits microtubule formation by binding to tubulin, inhibiting cell movement and division; Inhibits neutrophil activation APP: Acute Gout, Prevention of recurrent Gout AE: Myelosuppression and neuropathy CI: Severe cardiac, GI (due to decreased epithelial turnover), or Renal Disease CI: Hepatic Failure and Blood dyscrasias TC: DOSE SHOULD BE LOWERED WHEN ADMINISTERED WITH CYCLOSPORINE, TACROLIMUS, and /or VERAPAMIL |
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Mech: Mimic cortisol function by acting as glucocorticoid receptor APP: Acute polyarticular Gout AE: Immunosupression, cataracts, anything that excess cortisol causes CI: Systemic fungal infection |
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Definition
Mech: Mimic cortisol function by acting as glucocorticoid receptor APP: Acute polyarticular Gout AE: Immunosupression, cataracts, anything that excess cortisol causes CI: Systemic fungal infection TC: MAY BE INJECTED INTO AN INFLAMED JOINT FOR TREATMENT OF ACUTE GOUT |
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Allopurinol and Oxypurinol (product of Allopurinol degradation) |
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Definition
Mech:Inhibit Xanthine Oxidase (structural analog of Xanthine) APP: Chronic Gout, Cancer related hyperurecemia, Calcium and uric acid renal calculus AE: Agranulocytosis, Aplastic Anemia, Renal Failure, Hepatic Necrosis, SJ Syndrome, and Toxic epidermal necolysis CI: Idiopathic hemochromatosis TC: Increase levels of Azathiopine and 6-mercaptupurine TC: AMOXICILLIN, AMPICILLIN, AND THIAZIDE DIURETICS MAY CAUSE SEVER RASH TC: NEVER ADMINISTER DURING AN ACUTE ATTACK!!! TC: SHOULD BE ADMINISTERED WITH NSAID OR COLCHICINE FOR FIRST 4-6 MONTHS |
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Definition
Mech: Inhibit Xanthine Oxidase APP: Prevention of recurrent Gout AE: Myocardial infarction, stroke, Abnormal liver enzymes CI: Cannot use with MERCAPTOPURINE THEOPHYLLINE, OR AZATHIOPRINE TC: SHOULD BE USED WITH COLCHICINE |
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Definition
Mech: Inhibits renal tubule URAT1 and other transporters, increasing Uric acid secretion APP: Prevention of recurrent Gout AE: Leukopenia, Thrombocytopenia, Bronchoconstriction in patients with Gout CI: Acute Gout Attack, Uric acid kidney stones TC: Increase levels of penicillin and other organic anions TC: HAS ANTI-PLATELET EFFECTS |
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Definition
Mech: Inhibits renal tubule URAT1 and other transporters, increasing Uric acid secretion APP: Prevention of recurrent gout and chronic hyperurecemia AE: Thrombocytopenia, bronchoconstriction, APLASTIC ANEMIA, HEPATIC NECROSIS, ANAPHYLAXIS AND KIDNEY STONES CI: Acute gout attack, uric acid kidney stones TC: INCREASES levels of PENICILLIN and serum levels of METHOTREXATE |
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Mech: Angiotension II receptor antagonist APP: Hypertension and prevention of recurrent gout AE: Angioedema, rhabdomyolysis CI: Pregnancy |
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Definition
Mech: converts soluble urate to more solluble allantoin APP: TUMOR LYSIS SYNDROME AE: Hemolysis, methemoglobinemia, neutropenia, respiratory distress, sepsis, fever CI: G6PD déficience or aspergillus sensitivity TC: RECOMBINANT FORM OF ASPERGILLUS URICASE |
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Definition
Mech: converts soluble urate to more solluble allantoin APP: TREATMENT OF GOUT UNRESPONSIVE TO STANDARD TREATMENTS AE: Hemolysis, methemoglobinemia, neutropenia, respiratory distress, sepsis, fever CI: G6PD déficience or aspergillus sensitivity TC: MANUFACTURED URICASE WITH A LONGER HALF LIFE |
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Definition
Mech: Inhibit COX, preventing prostaglandin and thromboxane synthesis APP: Acute Gout attacks AE: Bleeding, salt and water retention, and renal insufficiency TC: HAVE TO DECIDE BETWEEN THIS DRUG AND COLCHICINE |
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