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Chapter 4
Cell Membrane Transport
60
Physiology
Undergraduate 1
02/01/2010

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Term
Fluid mosaic model
Definition
all cells have a plasma membrane made of a phospholipid bilayer with various other embedded and assoicated molecules
Term
Forces that act on particles
Definition
chemical
Electrical
Electrochemical (or net electrochemical)
Term
Chemical Force
Definition
a force that acts to push particles down their concentration gradient (high to low)
random motion of particles
acts on each kind of particle independently
Term
If K+ ions are more concentrated in side a cell than outside which direction is the chemical force acting on K+
Definition
outward
Term
Electrical force
Definition
this force arises when the inside and outside of a cell have different concentrations of ositive and negative charges
Term
If the inside of a cell has more negative charges than the outside the membrane voltage (Vm) is
Definition
negative or Vm<0
Term
If the inside of a cell has more positive charges that the outside, we say that the membrane voltage (Vm) is
Definition
postive or Vm>0
Term
If the inside and outside of the cell have equal numbers of positive and negative charges, we say the membrane voltage is
Definition
zero
Term
Do neutral charges feed electrical forces
Definition
NO
Term
Positively charged particles feel a force towards the more
Definition
negative region
Term
Negatively charged particles feel a force towards the more
Definition
positive region
Term
Eletrochemical force
Definition
is the sum of teh electrical and chemical forces
Term
What are the three passive transports
Definition
Diffusion through the phospholipid bilayer
Facilitated diffusion
Diffusion through channels
Term
Passive transport
Definition
particles always go dwon their electrochemical gradient (in the direction of the net electrocheical force)
Term
Diffusion through the phospholipid bilayer
Definition
requires no energy expenditure by the cell
a carrier protein undergoes a conformational change, to flip the particle to the other side of the membrane
Term
Glucose carrier
Definition
can transport up to 10,000 glucose molecuse per second
Term
Diffusion through channels
Definition
Requires no energy expenditure by the cell
Channels are like pores they allow particles to flow in either direction
Term
What are the two types of channels
Definition
Water channels
Ion channels
Term
Water channels
Definition
also called aquaporins - allow only water to pass through - do not allow solutes to pass through
Term
Water channels are especially important in what two systems
Definition
digestive and urinary
Term
Water channels net movement of water is always in what direction
Definition
down the concentration gradient (from area of lower osmolarity to area of higher osmolarity)
Term
Ion Channels
Definition

for ions only ( and a little water that goes with them) net movement of ions through channels is down the electrochemical gradient of that ion

Term
Active transport
Definition
Requires energy
moves molecules agianst their net electrochemical gradient
Term
What are the two types of Active transport
Definition
Primary
Secondary
Term
Primary active transport
Definition
proteins
use ATP to move particles agianst their gradient
show preference to bind a particle on one particular side and release it on the other
Term
Examples of primary active transport
Definition
calcium pumps in muscle cells H+/K+ pumps in the lining of stomach, which make the stomach contents acidic
Term
Secondary active transport
Definition
harness energy released by the passive transport of one kind of particle, to drive active transport of another kind of particle
EX: Sodium-linked glucose transport
Term
Endocytosis
Definition
a vesicle buds off towardthe inside of the cell, bringing in whatever contents are trapped inside
EX: white blood cells engulfing bacteria
Term
Exocytosis
Definition

A vescile fuses with the membrane, releasing contents  outside

 

EX: Neurotransmitter release

Term
Water transport
Definition
osmolarity
Term
Osmolarity
Definition
is the measure of solute concentration in water
Term
Will water flow from an area of lower osmolarity to an area of higher osmolarity
Definition

Yes - lower solute concentration or more dilute

or "higher water concentration" to higher solute concentration,

or less dilute, or "lower water concentration"

Term
Osmosis
Definition
Diffusion of water across a membrane
Term
Tonicity
Definition
refers to whethr a solution causes a cell placed in it to shrink or swell. Is determined by the relative concentrations of impermeant solutes only, in the solution and the ICF
Term
If transport of molecules across a membrane requires energy is this active transport or passive transport
Definition
Active transport
Term
The movement of a molecule into or out of the cell by its own thermal motion is called what
Definition
simple diffusion
Term
Active transport is always mediated by transport proteins referred to as
Definition
pumps
Term
The energy of solution depends on
Definition
solute concentration
Term
Do solutes move passively from an area where they are in greater concentration to an area where they are in lesser concentration
Definition
Yes - they move down their concentration gradient which requires an input of energy
Term
What are the three types of driving forces
Definition
chemical
energy
electrochemical
Term
We refer to a concentration gradient as a _______________ the direction of which is always down the concentation gradient
Definition
chemical driving force
Term
ions are are influenced by type of driving force
Definition
electrical- postive and negative charges
Term
What two two driving forces influence ions during transportation
Definition
1) a chemical force reflecting the ions' tendency to move down their concentration gradient (from higher to lower)
2) an electrical force reflecting the ions' tendency to be pushed in one direction or the other by the membrane potential
Term
The total force acting on the ions is the combination of chemical and electrical driving forces, referred to as
Definition
electrochemical driving force
Term
If a chemical reaction is neither forward nor backward what is this called
Definition
equilibrium
Term
What types of passive transport are there
Definition
simple diffusion
facilitated diffusion
diffusion through ion channels
Term
Simple diffusion
Definition
passive transport through membrane's lipid bilayer
Term
diffusion
Definition
the movment of molecules from one location to another
Term
When a substance is transported passively across a membrane by simple diffusion, the rate at which it is transported depends on three factors
Definition
the magnitude of the driving force
the membrane surface area
the permeability of the membrane
Term
Conduction
Definition
the transfer of thermal energy from one object to another that occurs when the obects are in direct contact with each other in the nervouse system the progagation of action potentials along an axon
Term
In simple diffusion, do individual molecules always go down their concentration gradient
Definition
Yes - because they are in a state of constant thermal motion
Term
In simple diffusion the rate of transport is directly related to what
Definition
the size of the driving force
Term
Carrier
Definition

is a transmembrane protein that binds molecules on one side of membrane and transports them to the other side by means of conformational change, or change in shape

Term
Carrier in facilitated diffusion
Definition
a transmembrane protein that binds molecules on one side of a membrane and transports them to the other side by means of a conformational change, or a change it shape
Term
What type of substances are transported by carriers
Definition
monosaccharides and amino acids
Term
The rate of facilitated diffusion is determined entirely by three factors
Definition

1) the transport rate of individual carriers

2) the number of carriers in the membrane

3) the magnitude of the concentration grandient of the transported substance

Term
Channel
Definition
is a transmembrane protein that transports molecules via a passageway or pore that extends from one side of the membrane to the other
Term
What are two types of channels
Definition
water channels (aquaporins) and ion channels
Term
cotransport
Definition
the transport of two substances in the same direction
Term
countertransport
Definition
the transport of two substances in opposite directions
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