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Chapter 40-41
Neural Signaling and Regulation
68
Biology
Undergraduate 1
04/11/2010

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Term
Nerve Net
Definition
Nerve cells scattered in body
No central organ
ex: Cnidarians
Term
Radial Nervous System
Definition
Nerve ring and nerves extend to various parts of the body

Ex: Echinoderms
Term
Bilateral Nervous System
Definition
nerve cells concentrate, form:
-nerves, nerve cords, ganglia, brain

Sense Organs:
-typically concentrated in head

Increased # of interneurons, more complex synaptic contacts:
-permit wide range of responses
Term
Planarian flatworms
Definition
Cerebral ganglia
Ventral nerve cords
Transverse nerves
Term
Annelids and Arthropods
Definition
Ventral nerve cord
Numerous ganglia
-cerebral ganglia(arthropods)
Term
Two main divisions of vertebrate nervous system
Definition
Central nervous system:
-brain, spinal cord

Peripheral nervous system:
-sensory receptors and nerves
Term
Vertebrate embryo
Definition
Brain and spinal cord arise from the neural tube

Anterior end of neural tube differentiates into:
-hindbrain
-midbrain
-forebrain
Term
Structure of human brain
Definition
Protected by bone and 3 meninges
-dura mater
-arachnoid
-pia mater

Cushioned by cerebrospinal fluid (CSF)
Term
What are spaces in the brain called?
Definition
Ventricles
Term
Structure and function of Spinal Cord
Definition
Transmits impulses to and from brain:
-ascending tracts (info to brain)
-descending tracts(info from brain)
Controls many reflex actions
Gray matter
-contains nuclei that serve as reflex centers
Term
Structures of the Cerebrum
Definition
White matter
-lies beneath cerebral cortex
Corpus callosum
-large band of white matter
-connects R & L hemispheres
Basal ganglia
-cluster of nuclei w/in white matter
-important centers for motor funct
Term
What are the functional areas of the cerebrum?
Definition
Occipital lobe-sight

etc...
Term
Limbic System of the brain
Definition
Affects emotional aspects of behavior
-motivation
-sexual activity
-autonomic responses
-biological responses
Term
Parts of the limbic system
Definition
Hippocampus:
-helps categorize info
-consolidates memories

Amygdala:
-evaluates incoming info
-signals danger
Term
Info processing
Definition
Learning
-process of acquiring knowledge or skills as a result of experience

Memory
-process by which info is encoded, stored, and retrieved
Term
What are the types of memory?
Definition
Implicit memory

Explicit memory

Short-term

Long-term
Term
Implicit memory
Definition
-unconscious how-to memory
-for perceptual and motor skills
Term
explicit memory
Definition
factual memory of people, places, objects
Term
Short-term memory
Definition
recalls info(like phone #) for a few minutes

info can be transferred from short to long memory
Term
Learning
Definition
long-term functional changes at synapses
Term
Long-term potentiations
Definition
increased sensitivity to an action potential by a postsynaptic neuron
Term
long-term depression
Definition
long-lasting decrease in strength of synaptic connections
Term
Sympathetic systems
Definition
permits the body to respond to stressful situations
Term
parasympathetic system
Definition
influences organs to conserve and restore energy

ex: digestive, metabolism
Term
Peripheral nervous system
Definition
made up of :
-sensory receptors
-neurons outside the CNS
Term
What are the steps of Response to a Stimulus?
Definition
1. Reception
2. Transmission by afferent
3. Integration
4. Transmission by efferent
5. Action by effectors
Term
What is the structure of a typical neuron?
Definition
Dendrites
Axon
Nodes of Ranvier
Schwann cell
Myelin Sheath
Synaptic terminals
Cell body
Term
Nodes of Ranvier
Definition
Where 2 myelin sheaths come together

axon is not covered by the myelin here

Na+ channels are concentrated
Term
Schwann Cell
Definition
coats the axon to speed up signal transmission

Forms sheaths around axons in PNS
Term
Nerve
Definition
several hundred axons
wrapped in connective tissue
Term
Ganglion
Definition
Mass of neuron cell bodies in the PNS
Term
Glial Cells
Definition
support/nourish cells

A type of schwann cell

important in neural communication
Term
Astrocytes
Definition
A type of glial cell:
-physically support neurons
-regulate extracellular fluid in CNS
-communicate with one another & with neurons
-induce and stabilize synapses
Term
Oligodendrocytes
Definition
form myelin sheaths around axons in CNS
Term
Microglia
Definition
phagocytic cells
Term
Ependymal Cells
Definition
Line cavities in the CNS

Contribute to formation of cerebrospinal fluid

serve as neural stem cells
Term
How do neurons send signals?
Definition
-Electrical signals transmit info along axons
-Plasma membrane of resting neuron(not transmitting) is polarized
-Inner surface of plasma membrane is negatively charged relative to the extracellular fluid
Term
What is the approximate resting potential of a neuron?
Definition
Potential difference of about :
-70 mV across the membrane
Term
What determines the magnitude of resting potential?
Definition
-Differences in ion concentrations inside cell relative to extracellular fluid

-selective permeability of plasma membrane to these ions
Term
What gives the cells charges?
Definition
-Ions passing through specific passive ion channels.
-K+ leak out faster than Na+ leak in
-Cl- accumulates at inner surface of plasma membrane
-Large ions can't cross membrane, so contribute to negative charge.
Term
Describe the Sodium-Potassium pump
Definition
It maintains gradients that determine resting potential by transporting 3 Na+ out for ever 2 K+ in.

It requires ATP
Term
Resting potential of a neuron is maintained by..
Definition
Differences in concentrations of specific ions inside the cell relative to extracellular fluid

Selective permeability of the plasma membrane to these ions
Term
Graded Potential
Definition
-A local change in electrical potential
-Varies in magnitude depending on the strength of the applied stimulus
-Fades out within a few mm of point of origin
Term
Action potential
Definition
-An electrical signal resulting from depolarization of the plasma membrane in a neuron or muscle cell
-wave of depolarization that moves down the axon
Term
Membrane potential
Definition
depolarized:
-if stimulus causes membrane potential to become less negative
hyperpolarized:
-if membrane potential becomes more negative than resting potential
Term
How is an action potential generated?
Definition
-When voltage across membrane declines to a threshold level
-voltage-activated ion channels open
-Na+ ions flow into the neuron
Term
Describe transmission of an Action Potential
Definition
An all or none response:
-No variation in strength of a single impulse

-either exceeds or doesn't
Once begun, it must finish

As moves down an axon, repolarization occurs behind it
Term
Refractory period
Definition
The brief period that elapses after the response of a neuron or muscle fiber, during which it cannot respond to another stimulus.
Term
What are the 2 types of refractory periods?
Definition
Absolute:
-can not transmit another action potential

Relative:
When enough gates controlling Na+ have ben reset, the threshold is higher for an action potential to reach
Term
Saltatory Conduction
Definition
-The transmission of a neural impulse along a myelinated neuron
-ion activity at one node depolarizes the next node along the axon
-more rapid than continuous
Term
Continuous Conduction
Definition
-Involves entire axon plasma membrane
-takes place in unmyelinated neurons
-must pass entire length of axon, so is slower than saltatory
Term
Synapses
Definition
Junction between 2 neurons or between a neuron and an effector

Most are chemical, some are electrical
Term
What do synaptic vesicles contain?
Definition
Neurotransmitters
Term
How do neurons signal other cells?
Definition
By releasing neurotransmitters at synapses
Term
What ion makes a synapse work?
Definition
Calcium
Term
How is a neural impulse transmitted across a synapse?
Definition
-Calcium ions cause synaptic vesicle to fuse with presynaptic membrane and release neurotransmitter into synaptic cleft
-Neurotransmitter diffuses across synaptic cleft and combines with specific receptors on a post synaptic neuron
Term
Synaptic transmission
Definition
a presynaptic neuron releases neurotransmitter(chemical messenger) from its synaptic vesicles.
Term
Excitatory postsynaptic potential (EPSP)
Definition
A change in membrane potential that brings a neuron closer to the firing level
Term
Inhibitory postsynaptic potential (IPSP)
Definition
A change in membrane potential that takes a neuron farther from the firing level.
Term
Temporal Summations
Definition
Occurs when repeated stimuli cause new EPSPs to develop before previous EPSPs have decayed
Term
Spatial Summation
Definition
Occurs when several closely spaced synaptic terminals release neurotransmitter:
simultaneously stimulating postsynaptic neuron at several different places
Term
What happens during integration?
Definition
-Incoming neural signals are summed
-temporal and spatial summation can bring a neuron to threshold level
Term
Convergence
Definition
several presynaptic neurons synapse with one postsynaptic neuron
Term
Divergence
Definition
A single presynaptic neuron synapses with many postsynaptic neurons.
Term
Reverberating Circuits
Definition
Important in rhythmic breathing, mental alertness, short-term memory

Depend on positive feedback:
-new impulses generated again and again until synapses fatigue
Term
What are the 2 types of reverberating circuits?
Definition
Simple

With interneuron
Term
Reverberating circuit with interneuron
Definition
-An axon collateral of the second neuron synapses with an interneuron.
-Interneuron synapses with the first neuron in the sequence
New impulses are triggered again and again in the first neuron, causing reverberation
Term
Simple reverberating circuit
Definition
An axon collateral of the 2nd neuron turns back on its own dendrites, so the neuron continues to stimulate itself
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