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chapter 39
structure function and disorders of integrument
142
Pathology
Undergraduate 1
03/24/2012

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Term
epidermis and dermis (true skin)
Definition
two layers of the sin
Term
Hypodermis
Definition
underlying layer of connective tisue that contains macrophages, fibroblasts, and fat cells
Term
Kerantinocytes, melanocytes, langerhans cells, and merkel cells
Definition
cell types of epidermis
Term
macrophages, mast cells, and histiocytes
Definition
cell types of dermis
Term
Stratum corneum (epidermis)
Definition
keratinocytes that has a tough superficial layer covering the body
Term
Stratum Lucideum (epidermis)
Definition
Kertainotcytes that has clear layers of cells containing eleidin, which becomes keratin as cells move up to the corneum layer
Term
Stratum granulosum (epidermis)
Definition
Keratinocytes and melanocytes and has keratohyalin that gives a grandular appearance to this layer
Term
papillary layer (dermis)
Definition
thin; mast cells that supply and contains sensry receptors and special glands
Term
Stratum spinosm (epidermis)
Definition
New keratinyocytes that are polygonal-shaped witspinous processes projecting between adjacent keratinoytes
Term
Stratum basale (germinativum)
Definition
keratinocytes, melanocytes, and merkel cells: Keratinocytes divide in the basal layer and move upward to replace cells that shed from the surface. Melanocytes in the basal layer synthesize pigment melanin. Merkel cells are associated with sensory nerve endings.
Term
Reticular layer (dermis)
Definition
thick, histiocytes that are wandering macrophages that collects pigments and inflammatory debris
Term
Macrophages (dermis)
Definition
cell type that has irregular connective tissue with rich blood, lymphatic and nerve
Term
Subcutaneous tissue
Definition
superficial fascia of varying thickness that connects the overlying dermis to underlying muscle
Term
Dermal appendages
Definition
 hair, nails, sebaceous glands, and eccrine and appocrine sweat glands
Term
Sebaceous glands
Definition
found in fast, chest, back,eyelids, lips, nipples, glans penis, and prepuce and secrets sebum
Term
Eccrine sweat glands
Definition
glands all over the body but more significant in palsm of hands, soles of feet, and forehead and is important for thermoregulation and cooling through evaporation
Term
Apocrine sweat glands
Definition
fewer, in the axillae, scalp, face, abdomen, and genital a rea
Term
pressure ulcers
Definition
ischemia ulcers from unrelieved pressure, shearing forces, friction, and moisture
Term
decubitus ulcer
Definition
ulcers or pressure sores that develop when an individual lies in the recumbent position for a long time
Term
Risk factors of pressure ulcers
Definition
immobilization, elderly people in hospitals and nursing homes, neurologic disorders (coma, spinal cord injuries, dementia, or cerebrovascular disease), incontinence, fractured femur, debilitation, lying in bed or sitting in chair or wheel chair without changing position or relieveing pressure over an extended period, lying for hours on hard x-ray and operating tables, chronic disease accmpanied by anemia, edeme, renal failure, malnutrition, sepsis, and urinary or fecal incontinence, coarse bed sheets used for turning by dragging, producing shearing forces
Term
Pressure ulcer stage I
Definition
nonblanchable erythema of intact skin
Term
Hyperemia
Definition
redness occurs with no lasting tissue damage
Term
Pressure ulcer stage 2
Definition
Partial-thickness skin loss involving epidermis or dermis.
Term
Pressure ulcer III
Definition
Full-thickness skin loss involving damage or necrosis of subcutaneous tissue that may extend to, but not through, underlying fasia
Term
pressure ulcer IV
Definition
Extensive destruction, tissue necrosis, or damage to muscle, bone or supporting structure with or without full-thickness skin loss
Term
Lesions
Definition
identiable structure changes in the skin structure
Term

Macule

 

Definition

flat, small (up to 1 cm), nonpalpable area of changed color

EX: flat moles, freckles, petechiae

Term
Papule
Definition

small, palpable, elevated and firm lesions up to 1 cm, and may vary in color

EX: wart, elevated moles, lichen planus

Term
Wheal
Definition

transitiory, usually ireegularly shaped of localized redness and edema that occurs as a normal response to skin trauma

EX: insect bites, allergic reaction, urticaria

Term
Nodule
Definition

large (greater than 1 cm), raised lesion that is often deeper and firmer than a papule

EX: erythema nodosum and Lipomas

Term
Vesicle (blister)
Definition

small (less than 1 cm) skin elevation that contained serious fluid

EX: Varicella, herpes zosterherpes blister

Term
Bulla
Definition
large vesicle (greater than 1 cm) filled with fluid
Term
Plaque
Definition

Larger (greater than 1 cm) solid elevated lesion, rough

EX: Psoriasis, seborrheic, and actinic keratoses

Term
Pustule
Definition

elevated, vesicle filled with purulent fluid

EX: Acne, impetigo

Term
Acne Vulgaris
Definition
inflammatory disorder of the pilosebaceous follicle and occurs during adolescence
Term
Cyst
Definition

elevated tumor containing liquid or semisolid material

EX: sebaceous cyst, custic acne

Term
Acne Rosea
Definition
chronic inflammation of the skint he dvelops in middle aged adults. Occurs in the middle third of the face (forehead, cheeks, nose, and chin). results in reddenning of the nose and cheeks, nose can develop hyperplasia Shouldn't drink hot or alcohol. Should use suncreen, photoprotection, topical agents, laser and light treatments
Term
Lupus erythematosus
Definition
autoimmune, systemic, inflammatory disease that expresses cutaneous manifestations
Term
Discoid lupus erthematosus
Definition

occurs in adults particularly in women in their late 30

s or early 40s. Caused by genetic and environmental factors and occurs mostly on the face. Use suncreen  or limit sun exposure and topical steroid relieves symptoms.

Term
Cutaneous infections
Definition
common forms if skin disease
Term
Bacterial, viral, and fungal
Definition
types of skin infections
Term
aerobes, anaeronbes, and yeast
Definition
the normal flora of the skin contains
Term
gram positive staphyloccoci and beta hemolytic stretococci
Definition
most common causative organisms of bacterial infections are
Term
erhythema and pustules
Definition
Bacterial infection lesions characterized as
Term
Folliculitis
Definition
staphylococcal/ S.aureus bacterial infection of the hair follicle. Lesion appear as pustules with surrounding erythema in the scalp and extremities. Clean with soap and water and use topical agents of antibiotics
Term
Furuncle (boil)
Definition
inflammation of the hair follicle  that has spread to surrounding tissue. Organism is S.aureus. initial lesion is deep, firm, red, painful nodule 1-5cm. Within a few days it can become large flunctuant and tender cystic nodule.
Term
Carbuncle
Definition
extension of a furuncle into several follicles and occurs in the back of neck, upperback, and lateral thighs. Erythematous, painful, swollen mass that drains through many openings. abscess may develop. Symtpoms fever, malaise. Drainage and incision and treat with antibiotics
Term
sty (hordeolum)
Definition
folliculitis one one of the stiff hairs of the eyelid
Term
contact dermatitis
Definition
skin inflammation due to exposure of an allergenic substance or irritant duration (prolonged or short)
Term
Chronic
Definition
with successive reoccurences of the disorder it can become
Term

After the irritant or allergen initially contacts the skin

 

Definition
reaction occurs with erythema, exudate, scaling and pruritis
Term
Allerigc contact dermatitis
Definition

1)a cell mediated response or delayed hypersensitivity response occurs

2) the allergin binds to a protein to form anti-genic molecule

3) sensitization occurs in the first exposure, manifestations occur after reexposure to the allergen

4) activation of the antigenic complex in the cutaneous tissue initates, and the inflammatory response symptoms include swlling and desicle formation

Term
Irritant contact dermatitis
Definition

1) the stratum corneum is damaged, slowly the irritant is absorbed into the skin

2) manifestations same as for allergic dermatitis

Term

Nursing interventions for contact dermatitis

 

Definition

1) assist with identification of the allergic substance or irritant

2) administer topical or oral antihistamines, as prescribe to inhibit the inflammatory response and to ease pruiritis

3) asses for secondary infection

Term
Eczema
Definition
common form of chronic dermatitis
Term
atopic and nummular
Definition
two types of eczema
Term
family history of asthma or allergic responses
Definition
Eczema is associated
Term
in childhood, but also occurs in adults
Definition
Eczema mostly occurs in
Term
nummular eczema
Definition
this is commonly developed in elderly men
Term
infantile atopic eczema
Definition

1) lesions begin in the cheeks and progree to the extremities and trunk, usually leaving diaper area clear

2)lesions start as vesicles, which can ooze and crust in the excoraited areas

Term
Adult atopic Eczema
Definition

1) markedly dry skin that is extremely itchy

2) scratching results in excoriation, lechenification, and scarring with leathery areas of hypo or hyerpigmented color left in the antecubital and popliteal parts of the body

Term
Nummular eczema
Definition

1) lesions develop as coin-shaped papulovesicular patches on the arms and legs

2)excoration and subsequent bacterial infections can lead to lichenification

3)Skin develops an inflammatory response to noxious stimuli, basodilation, sweeling of the upper dermal layer and damage to the epidermal alyer

Term
Acne
Definition
is localized inflammatory skin disorder characterized by papules, comedones (white head and backheads), pustules
Term
Acne vulgaris
Definition
most common disease seen in adolescent (12 to 25) with lesions on the face, neck, and upper body; genetic influences
Term
Acne conglobata
Definition
highly inflmmatory form of acne with communicating cyts ab\nd abscess beneath the skin that causes scarring
Term
oversecretion of sebum from sebaceous glands and hormonal dysfunction
Definition
cause of acne is unknown but it may have result from
Term
cosmetics, ingestion of certain drugs, exposure to grease or oil, contact with clothing, and emotional stress
Definition
factors of acne
Term
hypertropy and procudese more sebum
Definition
in acne, sebaceous glands are
Term
keratinization of the hair follicle
Definition
this obstructs the gland and causes sebum retention
Term
 comedones
Definition
these form and enlarge, and may rupture discharging their contents into the dermis or to the surface
Term
permanent scarring
Definition
what results eventually with acne
Term
Lichen Planus
Definition

chronic benign autoimmune papulosquamous disorder of the skin and mucous membranes

1) within the dermis and inflammatory response is initiated

2) lymmphocytic infiltration and hyperkeratosis occur, results in vacuolation and cell degeneration

3) lesions (found in buccal muscosa_ are pruitic papules with reddish purple color

4)whitish grey lines called wickhams striae may be present

5)larger scaly plaque may develop

Term
certain drugs and chemicals
Definition
the cause of lichen planus is unknown, however exacerbation (lesions) are associated with
Term
adults and has a duration of 15-24 months
Definition
Lichen planus affects
Term
antihistmaines, topical or systemic corticosteroid, acitrtrin, low molecular weight heparin and sulfasalazine
Definition
Treatment for lichen planus
Term
Psoriasis
Definition
chronic imflammatory papulosquamous condition resulting in silvery, scaly patched due to epidermal over growth
Term
genetic or biochemical alterations may be involved and there is familial predisposition
Definition
cause of psoriasis is unknown , however it is theroized that
Term

between ages 10 and 40

 

Definition
onset occurs for psoriasis
Term
Psoriasis
Definition

1) when keratinocytes mature, they moveup and out from the inner layer to replace the skin surface. AS they move they flatten, dehydrate, and become keratinized

2) in psoriasis, this process is sped up so that instead of epidermal replacement occuring every 21 days, it occurs every 5 days

3) vasolation of dermal vessels and leukocytes accumulation into the dermis result in erythema

4) because of increased mitotic rate, keratinization doesn't occur and the skins protective mechanism is impaired

5) lesions most commonly occur on elbows, knees, scalp, and are clearly demarcated

 

Term
plaque psoriatic lesion
Definition
well demarcated, thick, silvery, scaly, and erythematous surrounded by normal skin,
Term
treatment for psoriasis
Definition
reduce epidermal cell turnover and immunomodulation, emmolients, keratolytic agets, cortiosteroids. For moderate to severe: UV light, mehotrexate, acitretin, vit d, shampoos, and lotions. If severe, needs hospitalization
Term
Pityriasis rosea
Definition
inflammatory skin disease characterized by clusters of macules and papules surrounded by erythematous areas
Term
Pityrias
Definition
Term
unknown
Definition
the cause of pityriases rosea is
Term
pityriasis rosea
Definition
lesions of pityriasis rosea occur mostly in the winter spring/fall in young adults
Term

contagious; 6 weeks

 

Definition
pityriasis rosea is not contagious and is self limiting lasting about
Term
solitary (herald patch) with scaling
Definition
The initial lesions of pityriasis rosea
Term
on the face
Definition
lesions commonly occur on the trunk and upper extremetities, and they occur less often
Term
pruitus; fatique and headache
Definition

With pityriasis rosea, ________is common and ________ and _________ may also be present

 

Term
resolves in few months with symptomatic treatment for pruities , UV light, systemic cortiosteroids for itching, sun exposure
Definition
some treatments for pityriasis rosea
Term
Verrucae (warts)
Definition
family of common benign skin tumors composed of exagerated or irregularly thickened normal skin that is raised above the skin surface from the many different types of HPV
Term
Warts
Definition
the lesions are round, elevated with a rough, grayish surface, and can occur anywhere in the skin
Term
by touch
Definition
warts are transmitted by
Term
Verrucae vulgaris
Definition
common wart that vary in size from small, pinhead size growth to large patches (mosaic), which are seen on hands but can be anywhere or mucous membrane, esp. in children
Term
Verrucae plantaris
Definition
occur of the soles of the feet, extending deep into the thick skin pressure from walking, this causes pain
Term
Condyloma acuminate (venereal  warts)
Definition
These are cauliflower-like lesions, found in the anogenital area in adults and are typically sexually transmitted, if found in the anal area of a child, sexual abuse may be suspected.
Term
epidermodysplasia verruciforms
Definition
rare condition and is associated with warts all over the body
Term
topical salicylic acid or cryotherapy, remove by freezing them with liquid nitrogen, electrocautery, vaporization with liasers, imiquimod cream (anogenital warts{)
Definition

treatment for warts include

 

Term
Herpes
Definition
lesions that appear as painful vesicles that progress into ulcers, can occur anywhere but mostly found on the lips, mouth, face, and genitals
Term
Herpes Zoster
Definition
an acute viral infection in which lesions manifest along a unilateral nerve root segment or dermatome
Term
HSV1 and HSV 2
Definition
herpes is caused by two types of hermpes simplex virus infection
Term
HSV I
Definition
transmitted by contact of saliva and is generally associated with oral infections such as a cold sore or blister, fever blisters. these lesions make last up to 2-6 weeks and is symptomatic
Term
HSV II
Definition
associated with genital infections spread by skin to skin mucous membrane contact during viral shedding. This form is considered a sexually transmitted disease and is asymptomatic
Term
primary or secondary (recurrent)
Definition
herpes infections can be
Term
weather extremes, sunlight, hormonal, changes, and loca traum
Definition
precipitating events of herpes infection include
Term
Herpes zoster (shingles)
Definition
reactivated years later after varicella occured as primary infection. most common in adults over 50 Symptoms include pain and paresthesia localized to the affected dermatome.
Term
vesicles and pain
Definition
primary infection with HSV results in _________ and _________ and then within a few days, the vesicles open and dry up
Term
the first manifestation of herpes zoster
Definition
symptoms of localized pain over a particular nerve distribution area, erythema and vesicles occur that lasts about 3 weeks fever, malaise, and paethesia
Term
bacterial infections
Definition
has a variety of aquired skin lesions characterized by erythema and pustules and the most common type of organisms are gramy positive staphylococci and beta hemolytiv streptococci
Term
folliculitis
Definition
bacterial infection (s.aureas/ staphylococcal) of the hair follicles. Promient on scalp and extremities and causes systemic symptoms.
Term
cleaning with soap and water and using topical application of anitbiotics
Definition
treatment of folliculitis
Term
Furuncle (boil)
Definition
Acute inflammation of a hairfollicle that has spread to the surrounding tissue and the initial lesion is deep, firm red, and painful nodule that is 1-5cm. Within a few days it becomes larger and tender cystic. No systemic symptoms
Term
Carbuncle
Definition
extension of furuncle into several follicles in the back of the neck, upper back, and the lateral thighs. It has many drains from openings and is very painful, red and swollen. Chills, fever, and maliase are some symptoms and causes septicemia
Term
warm compression to provide comfrt anf promote drainage. With abscess formation a incision and drainage, and with recurrect infections antiobitics is given
Definition
treatment for furuncle and carbuncle are
Term
Infectious and inflammatory skin disorders
Definition

these causes the immune system to react to the presence of an antigen. causing ahypersensitivy reaction, or causes the body to react to infection

 

Term
skin disorders
Definition
these may result from ecposure to an allergen, bacterial, viral, ot function infection
Term
dermatitis, eczema,acne, lichen planus, psoriasis, pityriasis rosea, warts, herpes, bacterial and fungal infections
Definition
these are classified as infectious and infllamatory skin disorders
Term
Parasitic diseases
Definition
invasions of the skin by parasites (bugs) and can occur in any person at any time because parasites leap from one person to the next. When they lay eggs, infestations rapidly becomes extensive. The factor of having this disease is by having close contact with someone who has it
Term
Trauma (opening of the skin)
Definition
this is significant because it breaks the body's first line of defense. results from cuts, scrapes, stab wounds and other injuries. There are no specific risk factors for burn.
Term
burns
Definition
most sever type of skin trauma
Term
Skin cancer
Definition
this is attributed to exposure to ultraviolet rays and are associated with prolonef unprotected exposure to UVR.
Term
basal cell, squamous cell, and melanoma
Definition
types of skin cancer that are easily treatable
Term
Sty (hordeum)
Definition
folliculitis of one of stiff hairs of the eyelid that is pink and swollen
Term
Impetigo
Definition
superficial staphyloccal or stretoccal skin infection that is communicable in the young and esp common in children living in an unclean environment.Occurs in the mid summer to later summer where its hot and humid. has red macules that develop into vesiclea nd bullae which forms a honey yellow crust. Leading fluid causes the lesions to spread.
Term
acidic; resident bacterial
Definition
normally in the skin is ______ and contains _____that dont harm the host
Term
65 years
Definition
nearly all persons over age ________ will have had at least one cancer
Term
basal cell carcinoma and squamous cell carcinoma
Definition
most common types of skin cancer
Term
malignant melanoma
Definition
most serious skin cancer
Term
solar radiation
Definition
causes of most skin cancer
Term
Basal cell carcinoma
Definition
the most common skin cancer, growth rate is slow, has a nodule that is pearly or ivory or red, scaly and patch in appearance and slightly elevated above the skin with smal blood vessels on the surface. these tumors don't invase lymph or blood vessels so they dont metastasize but they grow by direct extension to adjacent structures
Term
Squamous cell carcinoma
Definition
tumor of epidermis and has two types: in situ and invasive.caused by sunlight and affects head and neck and hands. X-rays and gamma rays are also associated but its unknown what produces this. cells grow more rapidly than basal cell carcinomas and spreads to regional lymph nodes
Term
cutaneous melanoma
Definition

malignant tumor of the skin originating from melanocytes or ccells that synthesize the pigment melanin and ABECDE rule is used as a guide. Factors include genetic prepositions, solar radiaon, and steroid hormon activity, and sunlight.

 

Term
Kaposi sarcoma
Definition
vascular malignancy associated with ummuunodificiency states and occurs among transplant reciepients taking immunosuppresive drugs. Common in middle aged black men in africa and mediteranean or jewish descent. Lesions are purplish brown macules and develops into plaques and nodules;pruitic and painful. Diagnosed by skin biopsy and treated with x-intertferon, raiodtherapy, and cytotoxic drugs
Term
 in home
Definition
most significant burns occurs
Term
nonthermal or thermal resources
Definition
burns may be caused by
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