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Chapter 37
Viral Infections
45
Pharmacology
Graduate
09/03/2012

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Term
Miraviroc MOA
Definition
blocks HIV infection thru CCR5 attachment
Term
Miraviroc AE
Definition
infection, hepatotoxicity, MI, rash
Term
Enfuvirtide MOA
Definition
blocks HIV from fusing with GP41 and blocks membrane fusion
Term
Enfuvirtide AE
Definition
GB syndrome, renal, TCP, neutropenia, 6th nerve palsy, neuropathy
Term
Amantadine Rimantadine MOA
Definition
inhibit the influx of H+ thru M2 pore and block viral uncoating
Term
Amantadine Rimantadine TX
Definition
Infulenza A and Parkinsons
Term
Amantadine, Rimantadine AE
Definition
hypotension, edema, GI issues, confusion, dizziness
Term
Adefovir MOA
Definition
Anti HBV nucleoside analogue
Term
Lamivudine MOA
Definition
Anti HBV nucleoside analogue
Term
Entecavir MOA
Definition
Anti HBV nucleoside analogue
Term
Acyclovir, Valcyclovir TX
Definition
HSV, VZV
Term
Acyclovir, Valcyclovir MOA
Definition
inhibit viral DNA polymerase
Term
Acyclovir, Valacyclovir AE
Definition
Renal failure, TCP, encephalopathi issues, HUS, GI, dizzy
Term
Penciclovir, FamciclovirMOA
Definition
inhibits viral DNA polymerase
Term
Penciclovir, Famciclovir TX
Definition
HSV, VZV
Term
Penciclovir, Famciclovir AE
Definition
erythema multiforme, GI issues, headaches
Term
Ganciclovir, Valganciclovir TX
Definition
CMV
Term
Ganciclovir, Valganciclovir MOA
Definition
inhibits CMV DNA polymerase
Term
Ganciclovir, Valganciclovir AE
Definition
neutropenia, TCP, anemia
Term
Cidofovir TX
Definition
CMV retinitis with probenceid
Term
Cidofovir MOA
Definition
inhibit CMV DNA polymerase
Term
Vidarabine, Idoxuridine, Trifluridine TX
Definition
HSV keratitis (Early type very toxic)
Term
Zidovudine, Tenofovir, Emtricitabine MOA
Definition
HIV nucleoside analogues
Term
Zidovudine, Tenofovir, Emtricitabine AE
Definition
neutropenia, anemia, lactic acidosis, hepatomegally, optic neuritis
Term
Tenofovir, Adefovir, Entecavir AE
Definition
Lactic acidosis, hepatotoxicity, renal toxicity
Term
Foscarnet MOA
Definition
inhibits DNA polymerase thru pyrophosphate binding site
Term
Foscarnet TX
Definition
CMV and HSV
Term
Foscarnet AE
Definition
Renal toxicity
Term
Efavirenz, Nevirapine, etc MOA
Definition
NNRTI's bind reverse transcriptase at different site
Term
Efavirenz, Nevirapine, TX
Definition
HIV
Term
Raltegravir TX
Definition
HIV
Term
Raltegravir MOA
Definition
inhibits HIV integrase
Term
Raltegravir AE
Definition
hypercholesteremia, suicide risk, rhabdo,
Term
SaquiNAVIR, RitoNAVIR, DaruNAVIR, FosampreNAVIR MOA
Definition
inhibit HIV protease for maturation
Term
SaquiNAVIR, RitoNAVIR, DaruNAVIR, FosampreNAVIR AE
Definition
hyperlipedemia, lipodystrophy
Term
Zanamivir, Oseltamivir MOA
Definition
inhibit influenza neuramindase
Term
Zanamivir, Oseltamivir TX
Definition
Influenza A and B
Term
Fomivirsen TX
Definition
CMV retinitis second line
Term
Ribavirin TX
Definition
RSV and Hepatitis C with interfon-A
Term
Ribavirin AE
Definition
Hemolytic anemia, teratogen
Term
Docosanol TX
Definition
HSV
Term
Interferon-alpha TX
Definition
HCV, HBV, Kaposi, CML, Leukemia, Carcinoma
Term
Interferon-alpha MOA
Definition
blocks protein production in virus cells
Term
Imiquimod TX
Definition
HPV, basal cell carcinoma, Actinic keratosis
Term
Imiquimod MOA
Definition
interacts with Toll like receptors to increase innate immunity
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