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Chapter 33 Pharm
Micro drugs
28
Audiology
Undergraduate 3
05/08/2012

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Term
Ciproflaxacin
Levofloxacin
Definition
Inhibit topomerase II (DNA gyrase)
Term
Ciproflaxacin
Levofloxacin (TX)
Definition
Gram - infections UTI, RI, GI
Term
Ciprofloxacin
Levofloxacin (AE)
Definition
Gi issues, Rash, Tendo/Arthropathy
Term
Rifampin
Rifabutin
Definition
Bind to DNA dependant RNA polymerase
Term
Rifampin
Rifabutin (TX)
Definition
Meningoccal Disease, Mycobacterial TB, H. Influenza
Term
Rifampin
Rifabutin (AE)
Definition
TCP, Hepatotoxic, Red color to body fluids,
Term
Gentamicin, Streptomycin, Neomycin, Amikacin, Tobramycin
Definition
Binds to 30s and blocks protein synthesis, causes missreading
Term
Gentamicin, Streptomycin, Neomycin, Amikacin, Tobramycin (TX)
Definition
Serious gram - infections
Term
Gentamicin, Streptomycin, Neomycin, Amikacin, Tobramycin (AE)
Definition
Nephro/ototo toxicity, NM blockade--> resp distress
Term
Doxycycline "-cycline" (TX)
Definition
Acne, H. Influenza, Vibro cholerea, mycoplasma, lyme disease, chlamydia, gonnorhea, sphylis
Term
Doxycycline "-cycline"
Definition
Block 30s from binding tRNA to acceptor site
Term
Doxycycline "-cycline" (AE)
Definition
must take on empty stomach, teeth discoloration, light sensitivity, diarrhe X use in pregnanacy
Term
Azithromycin, Erythromycin, Clarithromycin "-thromycine"
Definition
binds to 50s subunit blocking translocation
Term
Azithromycin, Erythromycin, Clarithromycin "-thromycine" TX
Definition
Variety of infections, Corynebacterium, legionella, terepnonema, mycolasma, chlamydia, h. influenza, moraxella catarrhalis
Term
Azithromycin, Erythromycin, Clarithromycin "-thromycine" AE
Definition
cholestatic hepatitis, ototoxicity, hepatic necrosis, inhibits hepatic metabolism of anticoagulants
Term
Chloramphenicol
Definition
inhibits peptide bond formation by inhibiting tRNA positioning
Term
Chloramphenicol AE
Definition
hemolytic anemia, GREY BABY SYNDROME- baby lacks UDP-glucoronyl transferase
Term
Clindamycin
Definition
23rRNA: Inhibiting A and P Sites
bacterial infections of anaerobic nature
Term
Clindamycin (AE)
Definition
pseudomembranous colitis (ulcer, diarrhea fever) rash, jaundice
Term
Dalfopristin/quinupristin
Definition
binds to 50s subunit and prevents peptidyl transferase
Term
Dalfopristin/quinupristin TX
Definition
VR enterococcus faecium, MRSA/MSSA
Term
Linezolid
Definition
blocks 23S rRNA binding site
Term
Linezolid Tx
Definition
MRSA, VRE, PRS
Term
Retapamulin TX
Definition
impetigo due to s.pyogens
Term
Retapamulin TX
Definition
impetigo due to s.pyogens
Term
Spectinomycin
Definition
16s rRna : inhibits translocation used for gonnorhea
Term
Chloramphenicol TX
Definition
Broad spectrum against anaerobes and rikettsiae
Term
Quinolones are bacterialcidal or static?
Definition
Cidal
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