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Chapter 32 Biochem
Digestion of Lipids
22
Architecture
Kindergarten
02/02/2012

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Term
Cholestokinin
Definition
Released by intestines when undigested food enters---> release of pancreatic enzyes
Term
Pancreatic Lipase
Definition
Breaks down lipids into FA and 2-monoaglycerol
Term
Phospholipase A2
Definition
Breaks down phospholipids into FA
Term
Bile Salts
Definition
Binds to lipids and inactivates them
Term
Colipase
Definition
Binds to lipids that have already been inactivated by bile salts and allows the enhanced breakdown by lipases
Term
Secretin
Definition
instestines signal that there is too much acidic material entering, and bicarbonate must be secreted
Term
Immature Chylomicrons
Definition
Contain only TG, other lipids and Apop 48
Term
Mature chylomicrons
Definition
interaction with HDL adds apopE and apopCII
Term
Apop CII
Definition
recognized by LPL receptors of cappillary epithelial cells of muscle and adipose
Term
Apop E
Definition
recognized by receptors on Liver
Term
Packaging of TG and the addition of Apop48 occur where respectively
Definition
Intestinal SER and Intestinal RER
Term
Short and Medium Chain FA
Definition
4-12 Carbons: do not need bile salts for absorbtion, enter hepatic circulation bound to albumin
Term
Chylomicrons released:
Definition
into lymphatic flood enter blood at thorasic duct
Term
Amylase
Definition
produced in saliva cells and aciner cells of pancrease
Term
High levels of serum amylase
Definition
Pancreatitis or increase salivary production due to Mumps
Term
Human Breast milk importance
Definition
Contains long chain FA that are key to brain development
Term
Gall Stones occur due to what events
Definition
The inability of the liver to congugate all of the bilirubin that is produced leads to insoluble unconguated bilirubin precipitation which can calcify into stones
Term
Fat Soluble Vitamins
Definition
A,D,E,K: lack can occur due to fat malabsorbtion
Term
Hyperlipoproteinemia
Definition
High levels of Lipoprotein in blood can lead to a foamy cream layer in stagnent blood
Term
Orlostatin
Definition
Fake fat substitute that takes good but can not be absorbed by intestines, bc it cant be broken down by lipase---30% fat loss
Term
Heparin
Definition
seperates LPL from blood vessels and can lead to increased TG in the blood
Term
Abetalipoproteinemia
Definition
The LACK of MTP does not allow TG to be packaged with Apop48/Apop100 (liver) thus there is lipid malabsorbtion, vomiting, fatty stools,weight loss and vit. deficency
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