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Chapter 3 Key Terms
Protein Structure and Function
34
Biology
Undergraduate 3
02/18/2012

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Term
prebiotic soup
Definition
molecules accumulated in the shallow waters of the ancient
Term
amino acids
Definition
(20) a small molecule w/ central carbon atom bonded to an amino group
Term
hydrophobic
Definition
water doesn't interact with them
Term
monomer
Definition
a molecular subunit
Term
polymerization
Definition
when monomers are linked together
Term
protein
Definition
a polymer (macromolecule) consisting of linked amino acid monomers (50 or more amino acids)
Term
macromolecule
Definition
very large molecule made up of smaller molecules joined together (polymers)
Term
condensation reactions
Definition
dehydration reactions (water molecule taken out)
Term
peptide bond
Definition
the C-N bond that results from a condensation reaction
Term
polypeptide
Definition
resulting molecule from amino acids linked together by peptide bonds into a chain
Term
oligopeptide
Definition
when less than 50 amino acids are linked together (peptide)
Term
catalyze
Definition
(speed up) substance that lowers the activation energy of a reaction and increase rate of reaction
Term
enzyme
Definition
a protein that functions as a catlyst
Term
primary structure
Definition
what biochemists call the unique sequence of amino acids
Term
secondary structure
Definition
distinctively shaped sections of proteins that are stabilized largely by hydrogen bonding
Term
alpha helix
Definition
polypeptide's backbone is coiled
Term
beta-pleated helix
Definition
parts of a peptide chain bend & then fold in the same plane
Term
tertiary structure
Definition
overall shape
Term
van der Waals interactions
Definition
weak electrical attractions
Term
disulfide bonds
Definition
bridges between distinct regions of the same polypeptide
Term
quaternary structure
Definition
overall 3-d shape determined by the number, relative positions, and interactions of the subunits
Term
multienzyme structure
Definition
group of enzymes that are physically attached to each other, even though each of the enzymes catalyzes a separate but usually related chemical reaction
Term
denatured
Definition
unfolded
Term
molecular chaperone
Definition
A protein that facilitates the three-dimensional folding of newly synthesized proteins, usually by an ATP-dependent mechanism
Term
prion
Definition
An infectious form of a protein that is thought to cause disease by inducing the normal form to assume an abnormal three-dimensional structure
Term
substrates
Definition
(1) A reactant that interacts with an enzyme in a chemical reaction.
(2) A surface on which a cell or organism sits.
Term
transition state
Definition
A high-energy intermediate state of the reactants during a chemical reaction that must be achieved for the reaction to proceed
Term
activation energy
Definition
amount of energy required to initiate a chemical reaction
Term
active site
Definition
portion of an enzyme molecule where substrates (reactant molecules) bind and react
Term
induced fit
Definition
change in the shape of the active site of an enzyme, as the result of the initial weak binding of a substrate, so that it binds substrate more tightly
Term
cofactor
Definition
metal ion or small organic compound that is required for an enzyme to function normally
Term
coenzymes
Definition
small organic molecule that is a required cofactor for an enzyme-catalyzed reaction
Term
competitive inhibition
Definition
Inhibition of an enzyme's ability to catalyze a chemical reaction via a nonreactant molecule that competes with the substrate(s) for access to the active site
Term
allosteric-regulation
Definition
Regulation of a protein's function by binding of a regulatory molecule
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