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chapter 28
Mr. Moulder Reproductive system
56
Biology
Undergraduate 2
05/30/2012

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Term
Chromosomal
Definition
- The Y chromosome determines "maleness".
XX = female XY = male
- The sry gene is located on the Y chromosome (sex determining region of the Y chromosome) which initiates male development around week 6 of embryonic development.
Term
Gonadal Gender
Definition
- Under the influence of the sry gene the undifferentiated gonad becomes male, femaleness is considered a default pathway, meaning that Ovaries develop in the absence of the sry. A female (XX) can develop male genitalia if the sry gene is transferred to the X chromosome (during crossing over in Meiosis).
Term
Hormonal
Definition
- Secreted by the differentiated gonad. Mullerian-inhibiting substance (MIS), secreted by the Sertoli cells of the Testes, causes regression of the Mullerian ducts that develop into the Oviducts and Uterus.
- Testosterone masculinizes the internal and external genitalia (that develop from the Wolffian ducts). This also effects brain
development.
Term
Spermatic Cord -
Definition
contains Ductus Deferens, vessels, nerves, Cremaster muscle (which elevates the testes, is continuous with the Internal Oblique muscle of the abdomen).
Term
Spermatogonia -
Definition
The diploid cells that undergo meiosis.
Term
Sertoli cells -
Definition
Help form the blood-testis barrier (immune protection), and support sperm development.
Term
Leydig cells -
Definition
Secrete testosterone.
Term
Seminiferous tubules
Definition
- Located within the lobules of the testes. Area of sperm production (i.e. meiosis).
Term
Ductus Epididymis
Definition
- Lies on posterior testes. Region of storage and maturation of sperm.
Term
Ductus (Vas) Deferens
Definition
- Travels with in the spermatic cord, then through the inguinal canal into the pelvic cavity, loops over the Urinary Bladder towards its posterior surface.
Term
Ejaculatory duct
Definition
- Travels from the Seminal Vesicle to the Urethra, enters the Prostate gland below the Urinary Bladder.
Term
Urethra
Definition
- Common pathway for both Reproductive and Urinary Systems. Originates in the Prostate.
Term
Accessory glands
Definition
- Secrete the liquid portion of Semen.
Term
Seminal Vesicles
Definition
- Lie on the posterior bladder along its base.
Term
Prostate gland
Definition
- Surrounds the proximal Urethra.
Term
Bulbourethral glands
Definition
- Lie below the Prostate gland at the floor of the pelvis.
Term
Semen = Seminal fluid
Definition
- A mixture of sperm and fluids from the accessory glands and Seminiferous tubules, is slightly alkaline.
- Sperm counts below 20 million/ml are associated with infertility (sterility).
Term
Penis
a. Body -
Definition
- Male copulatory organ
- Composed of three cylindrical masses of erectile tissue.
Term
Corpus Spongiosum Penis -
Definition
The smaller, mid-ventral mass that contains the Urethra.
Term
Corpora Cavernosa Penis (X2)
Definition
- Lie dorsolaterally.
Term
Glans Penis
Definition
- Usually contains the External Urethral Orifice (Meatus)
- Covered by foreskin (Prepuce)
Term
Circumcision -
Definition
Surgical removal of the Prepuce.
Term
Ovary
Definition
- Female gonads, produce ovum (egg)
- Located in the posteriolateral pelvis, below the pelvic brim.
- Held in place by various ligaments.
- Produces estrogen, progesterone.
Term
Uterine (Fallopian) Tubes = Oviducts
Definition
- Transport ova to the Uterus.
- The lateral end opens into the peritoneal cavity = Infundibulum.
Term
- Fimbria =
Definition
Finger-like projections that extend from the Infundibulum.
Term
Isthmus =
Definition
Narrow, medial 1/3. Attaches to the superiolateral angle of the Uterus.
Term
Ampulla =
Definition
The widest, longest portion where fertilization usually takes place.
Term
Cervical Cancer -
Definition
Over 80% of the cases are associated with Human Papilloma Virus (HPV). Early diagnosis associated with the Pap smear.
Term
Stratum Functionalis -
Definition
Lines the Uterine cavity. Shed during menstruation
Term
Stratum Basalis -
Definition
The permanent layer that gives rise to the inner layer after menstruation.
Term
3 layers of the Uterus
a. Perimetrium -
b. Myometrium -
c. Endometrium -
Definition
a. Visceral, outer layer.
b. Middle layer that consists of three layers of smooth muscle. Thickest layer.
c. Vascular, inner layer. Two layers.
Term
Vagina
Definition
- Female organ of copulation.
- Passageway for menstrual flow and child birth.
- Fornix = Region around the Cervix.
- Vaginal orifice = Opening to the external environment.
Term
- Fornix =
Definition
Region around the Cervix.
Term
Mons Pubis =
Definition
Region over the Pubic Symphysis.
Term
Labia Majora =
Definition
Homologous to the Scrotum.
Term
Labia Minora =
Definition
Covers the Vestibule, homologous to the spongy urethra.
Term
Vestibule =
Definition
Area containing the hymen, external urethral orifice, vaginal orifice and glands that aid in sexual intercourse.
Term
Clitotis =
Definition
Small mass of erectile tissue that lies anterior to the junction of the Labia Minora. Homologous to the penis.
Term
Perineum
Definition
- The area between the thighs and buttocks in both males and females.
- Contains external genitalia and the anus.
Term
Mammary Glands
Definition
- Modified sudoriferous (sweat) glands that produce milk.
Term
- Alveoli =
Definition
Clusters of milk secreting glands.
Term
Lactation =
Definition
Secretion and ejection of milk.
- Milk passes through a series of ducts and sinuses before being ejected from the nipple.
Term
Areola =
Definition
The pigmented region surrounding the nipple. Designed for attachment and suckling.
Term
Prolactin -
Definition
An anterior Pituitary gland hormone that initiates and maintains milk secretion.
Term
Oxytocin -
Definition
A posterior Pituitary gland hormone that stimulates the release of milk in response to suckling. Also induces Uterine contractions during child birth.
Term
Testosterone
Definition
- Released by Leydig cells in response to Luteinizing Hormone (LH is secreted by the anterior Pituitary gland).
- Along with Follicle Stimulating Hormone (FSH is another anterior Pituitary gland hormone) Testosterone stimulates spermatogenesis.
- Causes male differentiation in utero, and descent of the Testes before birth.
- Involved in the development of secondary sexual characteristics, i.e. muscular and skeletal growth, extra hair growth, enlarged Larynx.
- Increases sex drive (libido).
- Increases protein synthesis.
Term
Estrogens
Definition
- Secreted by the follicle cells in the Ovary.
- Initiated by FSH secretion reacting with Primordial Cells.
- Promote the development and maintenance of secondary sexual characteristics, i.e. fat deposition in the breasts and hips.
- Increases protein synthesis and lowers cholesterol.
Term
Progesterone
Definition
- This is mainly secreted by the Corpus Luteum, along with estrogens.
- Helps prepare the Endometrium for implantation.
Term
Female Reproductive Cycle
Definition
1. Primordial Follicles begin to develop during Menses (FSH stimulation.
- The oocyte has been in stasis (in Prophase 1) since the individual was a fetus. Meiosis (Oogenesis) continues as this cell start to develop. The cell proceeds with meiosis to Metaphase 2.
2. One follicle cell (usually) develops faster than the others to become the Mature (Graafian) follicle. Around day 14 of development, the Mature follicle ruptures, releasing the secondary oocyte (the egg that is in Metaphase 2) into the pelvic cavity = Ovulation.
3. The Mature follicle develops into the Corpus Luteum. The developing follicle cells have been producing estrogens which stimulate the production of the Stratum Functionalis.
The Corpus Luteum secretes Progesterone and Estrogens which continue to stimulate the development of the Stratum Functionalis.
4. If no fertilization occurs, the Corpus Luteum degenerates into the Corpus Albicans. Progesterone and estrogen levels decrease, menses follows and the cycle is repeated.
5. If Fertilization occurs:
- The oocyte completes Oogenesis to become the Ovum.
- Sperm and ovum unite to become a Zygote (polar bodies are released which are reabsorbed by the body).
- As implantation occurs (approx. 8 days after ovulation), cells surrounding the embryo secrete Human Chorionic Gonadotropin (hCG). HCG stimulates the Corpus Luteum to continue producing hormones.
Term
Prostate Cancer
Definition
- The leading cancer related cause of death in men.
- The Prostate gland, surrounding the proximal Urethra, becomes enlarged, tender and its surface becomes irregular. Determined by digital exam.
- As this gland swells, the Prostate cells release more Prostate-Specific Antigen (PSA). The level of PSA can be evaluated by blood test to determine Prostate disorders.
- Incidence increases after 40 y/o.
Term
Breast Cancer
Definition
- Second leading cause of death from cancer in American women, after Lung Cancer.
- Incidence increases after menopause.
- Early detection is the best way to increase the survival rate.
Term
Candidiasis
Definition
- Infection with the fungi Candida albicans. Leads to vaginitis.
- Assoc. with severe itching, yellow discharge and yeasty odor.
- Often the result of Superinfection (Infection that follows antibiotic use.).
Term
Gonnorrhea
Definition
- STD caused by the bacteria N. gonorrhoeae (gonococcus).
- Symptom usually appear quicker and more severely in males.
- Males: Urethritis, pus discharge, painful urination.
- Females: Salpingitis, pus drainage.
- Can be transmitted to the new borne in the birth canal, can cause blindness.
- Treatment does not impart immunity.
Term
Pelvic Inflammatory Disease (PID)
Definition
- Infection of the pelvic organs.
- Low back pain and pelvic pain.
- Can lead to salpingitis and infertility.
- Over 50% of PID cases are assoc. with the gonococcus.
Term
Syphilis
Definition
- STD caused by the bacteria Treponema pallidum, a spirochete.
- Chancre = A painless open lesion associated with the early stages of Syphilis.
- Assoc. with latency periods = asymptomatic periods where the bacterium is very difficult to identify.
- Effects the Nervous System in its final stage, leading to degenerating mental status and death.
Term
- Chancre =
Definition
A painless open lesion associated with the early stages of Syphilis.
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